Acceptability of Home-Based Chlamydia And Gonorrhea Testing Among a National Sample Of Sexual Minority Young Adults

Author(s):  
Annie-Laurie McRee ◽  
Allahna Esber ◽  
Paul L. Reiter
BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e051118
Author(s):  
Alan G Nyitray ◽  
Vanessa Schick ◽  
Michael D Swartz ◽  
Anna R Giuliano ◽  
Maria E Fernandez ◽  
...  

IntroductionSquamous cell carcinoma of the anus is a common cancer among sexual minority men, especially HIV-positive sexual minority men; however, there is no evidenced-based national screening protocol for detection of anal precancers. Our objective is to determine compliance with annual anal canal self-sampling or clinician-sampling for human papillomavirus (HPV) DNA.Methods and analysisThis is a prospective, randomised, two-arm clinical study to evaluate compliance with annual home-based versus clinic-based HPV DNA screening of anal canal exfoliated cells. The setting is primary care community-based clinics. Recruitment is ongoing for 400 HIV-positive and HIV-negative sexual minority men and transgender persons, aged >25 years, English or Spanish speaking, no current use of anticoagulants other than nonsteroidal anti-inflammatory drugs and no prior diagnosis of anal cancer. Participants are randomised to either receive a swab in the mail for home-based collection of an anal canal specimen at 0 and 12 months (arm 1) or attend a clinic for clinician collection of an anal canal specimen at 0 and 12 months (arm 2). Persons will receive clinic-based Digital Anal Rectal Examinations and high-resolution anoscopy-directed biopsy to assess precancerous lesions, stratified by study arm. Anal exfoliated cells collected in the study are assessed for high-risk HPV persistence and host/viral methylation. The primary analysis will use the intention-to-treat principle to compare the proportion of those who comply with 0-month and 12-month sampling in the home-based and clinic-based arms. The a priori hypothesis is that a majority of persons will comply with annual screening with increased compliance among persons in the home-based arm versus clinic-based arm.Ethics and disseminationThe study has been approved by the Medical College of Wisconsin Human Protections Committee. Results will be disseminated to communities where recruitment occurred and through peer-reviewed literature and conferences.Trial registration numberNCT03489707.


2016 ◽  
Vol 47 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Jeffrey M. Cohen ◽  
Christine Blasey ◽  
C. Barr Taylor ◽  
Brandon J. Weiss ◽  
Michelle G. Newman
Keyword(s):  

2010 ◽  
Vol 34 (4) ◽  
pp. 213-226 ◽  
Author(s):  
N. E. Walls ◽  
J. Laser ◽  
S. J. Nickels ◽  
H. Wisneski

2011 ◽  
Vol 43 (3) ◽  
pp. 158-163 ◽  
Author(s):  
Christine E. Kaestle ◽  
Martha W. Waller

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