Natural products-based chemical biology research on leukemic cell differentiation

2012 ◽  
Vol 42 (12) ◽  
pp. 1774-1780
Author(s):  
YingLi WU ◽  
ChuanXu LIU ◽  
GuoQiang CHEN ◽  
QianQian YIN
Keyword(s):  
Natural Products ◽  
Cell Differentiation ◽  
Chemical Biology ◽  
Leukemic Cell ◽  
Biology Research

scholarly journals Neuroprotective Effects, Biological Activities and Therapeutic Potential of Phytochemicals: A Comprehensive Review

2020 ◽  
pp. 1-11
Author(s):  
Xi-jun Wang ◽  
Shi Qiu ◽  
Aihua Zhang ◽  
Jian-hua Miao ◽  
Hui Sun ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurological Disorders ◽  
Chemical Biology ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Neuroprotective Effects ◽  
Alternative Medicines ◽  
Pharmacological Targets ◽  
The World

The incidence of neurological disorders is growing in the world together with an increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathology, which make necessary to search for new therapeutic agents. Natural products, most of them used in phytochemicals from herbal medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Numerous herbs have been applied to neurodegenerative disease treatments as complementary and alternative medicines. In the 21st century, omics-coupled functional pharmacology was developed for neurodegenerative drug discovery from natural products. In this article, we firstly provide the latest understanding of neurological disorders on risk factors, category, diagnosis and treatment, and then specially present an overview of natural products in neuroprotective effects research from chemical biology to pharmacological targets, and also discuss the natural products application and future challenge.

scholarly journals PBK/TOPK Expression During TPA-Induced HL-60 Leukemic Cell Differentiation

2012 ◽  
Vol 13 (5) ◽  
pp. 2145-2148 ◽  
Author(s):  
Yu-Hong Liu ◽  
Xue-Mei Gao ◽  
Fan-Mei Ge ◽  
Zhe Wang ◽  
Wen-Qing Wang ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Leukemic Cell

Ultrastructural Study of Leukemic Cell Phagocytosis Using the Myeloperoxidase Reaction

1979 ◽  
Vol 65 (5) ◽  
pp. 517-526 ◽  
Author(s):  
Ermanno Pozzoli ◽  
Giorgio Lambertenghi-Deliliers ◽  
Davide Soligo ◽  
Maria Teresa Nava ◽  
Paola Zanon ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Cell Differentiation ◽  
Hematological Malignancies ◽  
Leukemic Cell ◽  
Blast Cell ◽  
Morphological Alteration ◽  
Phagocytic Capacity ◽  
Serum Factors ◽  
Severe Infections ◽  
Peripheral Leukocytes

The phagocytosis (in the absence of serum factors) of zymosan particles by peripheral leukocytes isolated from ten patients with acute leukemia (AMbL, AMoL, AMML, AUL, ALL and CML-BC) was studied at the electron microscope. An evident phagocytic activity was observed only in the cells in which cytochemical and ultrastructural features suggested that the blast elements belonged to the monocytic series. However, no phagocytosis by unclassifiable leukemic blasts was observed, even though they had some submicroscopic characteristics of the monocytic series. These findings suggest that phagocytic capacity develops during the course of cell differentiation, becoming striking only when the blast cell acquires the ultrastructural features of the pro-monocytic stage. Using the myeloperoxidase reaction, this study also demonstrates a morphological alteration in the degranulation process after the ingestion of zymosan particles in both the blasts and the mature PMN cells of leukemic patients. This defect could be related to the susceptibility to severe infections usually found in subjects with hematological malignancies.

Sign in / Sign up

Export Citation Format

Share Document