scholarly journals Introduction of New Tools for Chemical Biology Research on Microbial Metabolites

2010 ◽  
Vol 74 (6) ◽  
pp. 1135-1140 ◽  
Author(s):  
Hiroyuki OSADA
Keyword(s):  
Chemical Biology ◽  
Microbial Metabolites ◽  
Biology Research

Natural products-based chemical biology research on leukemic cell differentiation

2012 ◽  
Vol 42 (12) ◽  
pp. 1774-1780
Author(s):  
YingLi WU ◽  
ChuanXu LIU ◽  
GuoQiang CHEN ◽  
QianQian YIN
Keyword(s):  
Natural Products ◽  
Cell Differentiation ◽  
Chemical Biology ◽  
Leukemic Cell ◽  
Biology Research

scholarly journals Splicing modulators: on the way from nature to clinic

2021 ◽  
Author(s):  
Tilman Schneider-Poetsch ◽  
Jagat Krishna Chhipi-Shrestha ◽  
Minoru Yoshida
Keyword(s):  
Drug Discovery ◽  
Small Molecule ◽  
Chemical Biology ◽  
Mrna Processing ◽  
Mrna Splicing ◽  
Scientific Methodology ◽  
Experimental Drugs ◽  
Structure Activity ◽  
Scientific Tool ◽  
Biology Research

AbstractOver the course of more than two decades, natural products isolated from various microorganisms and plants have built the foundation for chemical biology research into the mechanism of pre-mRNA splicing. Hand in hand with advances in scientific methodology small molecule splicing modulators have become powerful tools for investigating, not just the splicing mechanism, but also the cellular effect of altered mRNA processing. Based on thorough structure-activity studies, synthetic analogues have moved on from scientific tool compounds to experimental drugs. With current advances in drug discovery methodology and new means of attacking targets previously thought undruggable, we can expect further advances in both research and therapeutics based on small molecule splicing modulators.

Chemical Trigger-enabled Bioconjugate Reaction

2021 ◽  
Author(s):  
Yefeng Tang ◽  
Fayang Xie ◽  
Xiangqian Jia ◽  
Zhu Zhu ◽  
Haolin Jiang ◽  
...  
Keyword(s):  
Chemical Biology ◽  
Biology Research

Development of conceptually novel and practically useful bioconjugate reactions has been an intense pursuit of chemical biology research. Herein, we report an unprecedented bioconjugate reaction that hinges on a chemical...

Chemical Biology Research in India

2011 ◽  
Vol 6 (10) ◽  
pp. 982-986 ◽  
Author(s):  
B. Ruthrotha Selvi ◽  
Siddhartha Roy ◽  
Tapas K Kundu
Keyword(s):  
Chemical Biology ◽  
Biology Research

scholarly journals The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3299
Author(s):  
Ludger Johannes
Keyword(s):  
Lipid Membranes ◽  
Tumor Targeting ◽  
Chemical Biology ◽  
Reverse Genetics ◽  
Lateral Diffusion ◽  
Intracellular Delivery ◽  
Membrane Bound ◽  
Delivery Strategies ◽  
Synthetic Approaches ◽  
Biology Research

Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective channels, and in eukaryotic cells for endocytic uptake through the formation of membrane bound vesicular or tubular carriers. Two of the most abundant fundamental fabrics of membranes—lipids and complex sugars—are produced through elaborate chains of biosynthetic enzymes, which makes it difficult to study them by conventional reverse genetics. This review illustrates how organic synthesis provides access to uncharted areas of membrane glycobiology research and its application to biomedicine. For this Special Issue on Chemical Biology Research in France, focus will be placed on synthetic approaches (i) to study endocytic functions of glycosylated proteins and lipids according to the GlycoLipid–Lectin (GL–Lect) hypothesis, notably that of Shiga toxin; (ii) to mechanistically dissect its endocytosis and intracellular trafficking with small molecule; and (iii) to devise intracellular delivery strategies for immunotherapy and tumor targeting. It will be pointed out how the chemical biologist’s view on lipids, sugars, and proteins synergizes with biophysics and modeling to “look” into the membrane for atomistic scale insights on molecular rearrangements that drive the biogenesis of endocytic carriers in processes of clathrin-independent endocytosis.

Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

2016 ◽  
Vol 33 (5) ◽  
pp. 648-654 ◽  
Author(s):  
Hideaki Kakeya
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Chemical Biology ◽  
Target Identification ◽  
Chemical Genetics ◽  
Phenotypic Screening ◽  
Cancer Microenvironment ◽  
Microbial Metabolites ◽  
Cellular Targets ◽  
Target Cancer

This highlight focuses on our recent discoveries and chemical genetics approaches for bioactive microbial metabolites that target cancer cells, the cancer microenvironment, and cell membrane signalling. In addition, the development of two new platforms to identify the cellular targets of these molecules is also discussed.

scholarly journals Novel Approaches in Biomolecule Labeling

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1809
Author(s):  
Cyrille Sabot ◽  
Péter Kele
Keyword(s):  
Nucleic Acids ◽  
Targeted Therapies ◽  
Biomedical Applications ◽  
Chemical Biology ◽  
Biological Processes ◽  
Selective Functionalization ◽  
Novel Approaches ◽  
Biology Research ◽  
Insight Into

The selective functionalization of biomolecules such as proteins, nucleic acids, lipids or carbohydrates is a focus of persistent interest due to their widespread use, ranging from basic chemical biology research to gain insight into biological processes to the most promising biomedical applications, including the development of diagnostics or targeted therapies [...]

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