Hepatitis C virus core protein detection by DNA aptamer

2011 ◽  
Vol 41 (8) ◽  
pp. 1312-1318 ◽  
Author(s):  
Zhen ZHANG ◽  
HaiZhen ZHU ◽  
WeiHong TAN ◽  
ZiLong ZHAO ◽  
XiaoHong FANG ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Protein Detection ◽  
Dna Aptamer ◽  
Virus Core

scholarly journals Detection of Hepatitis C Virus Core Protein in Serum Using Aptamer-Functionalized AFM Chips

Micromachines ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 129 ◽  
Author(s):  
Tatyana Pleshakova ◽  
Anna Kaysheva ◽  
Ivan Shumov ◽  
Vadim Ziborov ◽  
Jana Bayzyanova ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Protein Detection ◽  
Core Antigen ◽  
Serum Samples ◽  
Chip Surface ◽  
Force Microscopy ◽  
Virus Core ◽  
Complex Protein

In the present study, we demonstrate atomic force microscopy (AFM)-based detection of hepatitis C virus (HCV) particles in serum samples using a chip with aptamer-functionalized surface (apta-based AFM chip). The target particles, containing core antigen of HCV (HCVcoreAg protein), were biospecifically captured onto the chip surface from 1 mL of test solution containing 10 µL of serum collected from a hepatitis C patient. The registration of aptamer/antigen complexes on the chip surface was performed by AFM. The aptamers used in the present study were initially developed for therapeutic purposes; herein, these aptamers have been successfully utilized as probe molecules for HCVcoreAg detection in the presence of a complex protein matrix (human serum). The results obtained herein can be used for the development of detection systems that employ affine enrichment for protein detection.

Biosynthesis and biochemical properties of the hepatitis C virus core protein.

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Biochemical Properties ◽  
Virus Core

Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

2004 ◽  
Author(s):  
Rin Yamaguchi ◽  
Seiya Momosaki ◽  
Guang Gao ◽  
Chu Hsia ◽  
Masamichi Kojiro ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Virus Core ◽  
Hepatocellular Carcinomas

Genetic control of the murine humoral response to distinct epitopes of hepatitis C virus core protein

1995 ◽  
Vol 2 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Z. Chen ◽  
I. Berkower ◽  
R. Y.-H. Wang ◽  
W.-M. Ching ◽  
H. J. Alter ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Control ◽  
Core Protein ◽  
Humoral Response ◽  
Virus Core

Titration of antibody against hepatitis C virus core protein and its clinical utility

1993 ◽  
Vol 18 (1) ◽  
pp. 138-139 ◽  
Author(s):  
Yuko Taura ◽  
Shigetoshi Fujiyama ◽  
Shin-ichi Kawano ◽  
Shinjiro Sato ◽  
Masafumi Goto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Utility ◽  
Core Protein ◽  
Virus Core

scholarly journals The Hepatitis C Virus Core Protein Interacts with NS5A and Activates Its Caspase-Mediated Proteolytic Cleavage

Virology ◽  
2001 ◽  
Vol 290 (2) ◽  
pp. 224-236 ◽  
Author(s):  
Phuay-Yee Goh ◽  
Yee-Joo Tan ◽  
Siew Pheng Lim ◽  
Seng Gee Lim ◽  
Y.H. Tan ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Proteolytic Cleavage ◽  
Virus Core

scholarly journals Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein

2010 ◽  
Vol 67 (18) ◽  
pp. 3151-3161 ◽  
Author(s):  
Marion Depla ◽  
Rustem Uzbekov ◽  
Christophe Hourioux ◽  
Emmanuelle Blanchard ◽  
Amélie Le Gouge ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Quantitative Analysis ◽  
Hepatitis C ◽  
Lipid Droplet ◽  
Core Protein ◽  
Virus Core
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