Dose-determined effects of H3TDR as DNA label upon the liver cell replication time and pattern in the growing rat

1964 ◽  
Vol 8 (3-4) ◽  
pp. 499-506 ◽  
Author(s):  
J. Post ◽  
J. Hofmann
Keyword(s):  
Liver Cell ◽  
Cell Replication ◽  
Replication Time ◽  
Growing Rat

scholarly journals THE REPLICATION TIME AND PATTERN OF THE LIVER CELL IN THE GROWING RAT

1963 ◽  
Vol 18 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Joseph Post ◽  
Cheng-Ya Huang ◽  
Joseph Hoffman
Keyword(s):  
Dna Synthesis ◽  
Liver Cell ◽  
Tritiated Thymidine ◽  
Liver Cells ◽  
Male Rats ◽  
Interphase Nuclei ◽  
Replication Time ◽  
Wistar Strain ◽  
Growing Rat ◽  
Liver Cell Population

Three-week-old male rats of the Wistar strain were given tritiated thymidine, 1 µc/gm body weight, intraperitoneally and were killed at intervals from 0.25 to 72 hours later. Autoradiographs were made from 5 µ sections, stained by the Feulgen method. The replication time and its component intervals were determined from the scoring of the labeling of interphase nuclei as well as of prophase, metaphase, anaphase, and telophase nuclei. Absorption of the intraperitoneally injected label is rapid and is attended by "flash" labeling during interphase. The results show that at any one time about 4 per cent of the liver cells are synthesizing DNA preliminary to cell division. These cells alternate with waves of other cells and it is estimated that about 10 per cent of the liver cell population is engaged in cell duplication. The replication time is about 21.5 hours, and its component intervals occupy the following times: DNA synthesis, 9 hours; post-DNA synthesis gap, 0.50 hour; prophase, 1.3 hours; metaphase, 1.0 hour; anaphase, 0.4 hour; telophase, 0.3 hour; postmitosis gap, 9.0 hours. A group of liver cells has been recorded in at least 3 successive replication cycles.

scholarly journals CONTROL OF LIVER CELL REPLICATION BY ALBUMIN NEED

1967 ◽  
Vol 34 (1) ◽  
pp. 404-406 ◽  
Author(s):  
Alan D. Sudweeks ◽  
Rolla B. Hill
Keyword(s):  
Liver Cell ◽  
Cell Replication

Late Effects of H 3 TDR as a DNA Label on Liver Cell Replication

1967 ◽  
Vol 30 (4) ◽  
pp. 748 ◽  
Author(s):  
Joseph Post ◽  
Joseph Hoffman
Keyword(s):  
Liver Cell ◽  
Late Effects ◽  
Cell Replication

Effects of Hypophysectomy on the Fine Structure of Rat Liver Cells

1967 ◽  
Vol 25 ◽  
pp. 156-157
Author(s):  
Robert R. Cardell
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Rat Liver ◽  
Liver Cell ◽  
Anterior Pituitary ◽  
Liver Cells ◽  
Biochemical Studies ◽  
Liver Functions ◽  
Rat Liver Cells ◽  
And Control

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.

Recurrent Liver Cell Adenoma

1959 ◽  
Vol 37 (6) ◽  
pp. 760-765 ◽  
Author(s):  
S.W. Berkheiser
Keyword(s):  
Liver Cell ◽  
Cell Adenoma ◽  
Liver Cell Adenoma

Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
SA Hoffmann ◽  
M Lübberstedt ◽  
U Müller-Vieira ◽  
D Knobeloch ◽  
A Nüssler ◽  
...  
Keyword(s):  
Liver Cell ◽  
Human Liver ◽  
In Vitro Toxicity ◽  
Cell Cultivation ◽  
Toxicity Studies ◽  
Human Liver Cell ◽  
Bioreactor System

Liver cell specific TGF-beta sensitivity and outcome

2018 ◽  
Vol 56 (08) ◽  
pp. e251-e251
Author(s):  
M Han ◽  
ZC Nwosu ◽  
MP Ebert ◽  
S Hammad ◽  
C Meyer ◽  
...  
Keyword(s):  
Liver Cell ◽  
Tgf Beta

Pigmented Liver Cell Adenoma with Nodule-in-Nodule Appearance: Case Report

2004 ◽  
Vol 51 (3) ◽  
pp. 317
Author(s):  
Hyun Jun Choi ◽  
Jun Hyun Yun ◽  
Ji Hyeo Choi ◽  
Ju Hyun Im ◽  
Se Jong Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Cell ◽  
Cell Adenoma ◽  
Liver Cell Adenoma
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