Use of Intravenous Lipid Emulsion to Reverse Central Nervous System Toxicity of an Iatrogenic Local Anesthetic Overdose in a Patient on Peritoneal Dialysis

2012 ◽  
Vol 46 (12) ◽  
pp. 1723-1723 ◽  
Author(s):  
D Bruce Lange ◽  
Daniel Schwartz ◽  
Gerald DaRoza ◽  
Robert Gair
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Peritoneal Dialysis ◽  
Local Anesthetic ◽  
Lipid Emulsion ◽  
Central Nervous System Toxicity ◽  
Intravenous Lipid Emulsion ◽  
System Toxicity

scholarly journals Local Anesthetic-Induced Central Nervous System Toxicity during Interscalene Brachial Plexus Block: A Case Series Study of Three Patients

2021 ◽  
Vol 10 (5) ◽  
pp. 1013
Author(s):  
Daniel Spitzer ◽  
Katharina J. Wenger ◽  
Vanessa Neef ◽  
Iris Divé ◽  
Martin A. Schaller-Paule ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brachial Plexus ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Brachial Plexus Block ◽  
Central Nervous System Toxicity ◽  
Interscalene Brachial Plexus Block ◽  
Plexus Block ◽  
System Toxicity

Local anesthetics are commonly administered by nuchal infiltration to provide a temporary interscalene brachial plexus block (ISB) in a surgical setting. Although less commonly reported, local anesthetics can induce central nervous system toxicity. In this case study, we present three patients with acute central nervous system toxicity induced by local anesthetics applied during ISB with emphasis on neurological symptoms, key neuroradiological findings and functional outcome. Medical history, clinical and imaging findings, and outcome of three patients with local anesthetic-induced toxic left hemisphere syndrome during left ISB were analyzed. All patients were admitted to our neurological intensive care unit between November 2016 and September 2019. All three patients presented in poor clinical condition with impaired consciousness and left hemisphere syndrome. Electroencephalography revealed slow wave activity in the affected hemisphere of all patients. Seizure activity with progression to status epilepticus was observed in one patient. In two out of three patients, cortical FLAIR hyperintensities and restricted diffusion in the territory of the left internal carotid artery were observed in magnetic resonance imaging. Assessment of neurological severity scores revealed spontaneous partial reversibility of neurological symptoms. Local anesthetic-induced CNS toxicity during ISB can lead to severe neurological impairment and anatomically variable cerebral lesions.

scholarly journals Lipid emulsion mitigates local anesthesia-induced central nervous system toxicity in rats

2015 ◽  
Vol 10 (3) ◽  
pp. 1133-1138 ◽  
Author(s):  
GANGMING WU ◽  
BIN SUN ◽  
LI LIU ◽  
JUN ZHOU ◽  
LIQUN MO ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Local Anesthesia ◽  
Lipid Emulsion ◽  
Central Nervous System Toxicity ◽  
System Toxicity

Central Nervous System Toxicity of Local Anesthetic Mixtures in the Rat

1992 ◽  
Vol 75 (6) ◽  
pp. 922???928 ◽  
Author(s):  
David A. Spiegel ◽  
Franklin Dexter ◽  
David S. Warner ◽  
Max T. Baker ◽  
Michael M. Todd
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Local Anesthetic ◽  
Central Nervous System Toxicity ◽  
System Toxicity

CENTRAL NERVOUS SYSTEM TOXICITY OF LOCAL ANESTHETIC MIXTURES IN THE RAT

1992 ◽  
Vol 77 (Supplement) ◽  
pp. A894
Author(s):  
D. A. Spiegel ◽  
D. B. Warner ◽  
M. T. Baker ◽  
F. Dexter ◽  
M. M. Todd
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Local Anesthetic ◽  
Central Nervous System Toxicity ◽  
System Toxicity
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