scholarly journals Intravenous lipid emulsion modifies synaptic transmission in hippocampal CA1 pyramidal neurons after bupivacaine‐induced central nervous system toxicity

2020 ◽  
Vol 154 (2) ◽  
pp. 144-157
Author(s):  
Hao Nie ◽  
Zhixia Bai ◽  
Zhenzhou Li ◽  
Li Yan ◽  
Xue‐Xin Chen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Synaptic Transmission ◽  
Lipid Emulsion ◽  
Pyramidal Neurons ◽  
Central Nervous System Toxicity ◽  
Intravenous Lipid Emulsion ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
System Toxicity

scholarly journals Lipid emulsion mitigates local anesthesia-induced central nervous system toxicity in rats

2015 ◽  
Vol 10 (3) ◽  
pp. 1133-1138 ◽  
Author(s):  
GANGMING WU ◽  
BIN SUN ◽  
LI LIU ◽  
JUN ZHOU ◽  
LIQUN MO ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Local Anesthesia ◽  
Lipid Emulsion ◽  
Central Nervous System Toxicity ◽  
System Toxicity

Monitoring of tricyclic antidepressant plasma levels and clinical response: a review of the literature. Part II

1989 ◽  
Vol 4 (2) ◽  
pp. 81-90 ◽  
Author(s):  
I.R. De Oliveira ◽  
P.A.S. Do Prado-Lima ◽  
B. Samuel-Lajeunesse
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Elderly Patients ◽  
Plasma Levels ◽  
Tricyclic Antidepressant ◽  
Review Of The Literature ◽  
Central Nervous System Toxicity ◽  
Routine Measurement ◽  
System Toxicity

SummaryPart II of this paper contains some general considerations on tricyclic antidepressant (TCA) monitoring. Long-term assessment of TCA plasma levels is advised by the few existent studies, although each of these focusses on different aspects. Cardiovascular and central nervous system toxicity is reviewed as well as pharmacokinetics and the importance of protein binding. Some consideration is also given to their use in elderly patients. The authors conclude that although available data support its usefulness in many situations, routine measurement of TCA levels is not warranted.

scholarly journals Local Anesthetic-Induced Central Nervous System Toxicity during Interscalene Brachial Plexus Block: A Case Series Study of Three Patients

2021 ◽  
Vol 10 (5) ◽  
pp. 1013
Author(s):  
Daniel Spitzer ◽  
Katharina J. Wenger ◽  
Vanessa Neef ◽  
Iris Divé ◽  
Martin A. Schaller-Paule ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brachial Plexus ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Brachial Plexus Block ◽  
Central Nervous System Toxicity ◽  
Interscalene Brachial Plexus Block ◽  
Plexus Block ◽  
System Toxicity

Local anesthetics are commonly administered by nuchal infiltration to provide a temporary interscalene brachial plexus block (ISB) in a surgical setting. Although less commonly reported, local anesthetics can induce central nervous system toxicity. In this case study, we present three patients with acute central nervous system toxicity induced by local anesthetics applied during ISB with emphasis on neurological symptoms, key neuroradiological findings and functional outcome. Medical history, clinical and imaging findings, and outcome of three patients with local anesthetic-induced toxic left hemisphere syndrome during left ISB were analyzed. All patients were admitted to our neurological intensive care unit between November 2016 and September 2019. All three patients presented in poor clinical condition with impaired consciousness and left hemisphere syndrome. Electroencephalography revealed slow wave activity in the affected hemisphere of all patients. Seizure activity with progression to status epilepticus was observed in one patient. In two out of three patients, cortical FLAIR hyperintensities and restricted diffusion in the territory of the left internal carotid artery were observed in magnetic resonance imaging. Assessment of neurological severity scores revealed spontaneous partial reversibility of neurological symptoms. Local anesthetic-induced CNS toxicity during ISB can lead to severe neurological impairment and anatomically variable cerebral lesions.

Central nervous system toxicity with high-dose Ara-C

Neurology ◽  
1985 ◽  
Vol 35 (10) ◽  
pp. 1475-1475 ◽  
Author(s):  
T.-L. Hwang ◽  
W.K. A. Yung ◽  
E. H. Estey ◽  
W. S. Fields
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
High Dose ◽  
Central Nervous System Toxicity ◽  
System Toxicity
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