Irbesartan Substitution for Valsartan or Losartan in Treating Hypertension

2002 ◽  
Vol 36 (12) ◽  
pp. 1840-1844 ◽  
Author(s):  
Maqual R Graham ◽  
Nicole M Allcock
Keyword(s):  
Blood Pressure ◽  
Medical Records ◽  
Demographic Data ◽  
Pressure Measurements ◽  
Goal Blood Pressure ◽  
P Values ◽  
Assessment Visit ◽  
Before And After ◽  
Blood Pressures ◽  
Medical Histories

OBJECTIVE: To determine whether subjects whose therapy was converted from losartan or valsartan to irbesartan maintained equivalent blood pressure measurements, determine the safety and tolerability of irbesartan in the veteran population, and assess the number of subjects attaining their goal blood pressure before and after conversion. METHODS: A retrospective review of medical records for subjects whose antihypertensive was converted to irbesartan was conducted. Demographic data were collected, and subjects' past medical histories were used to determine their goal blood pressure. Blood pressures were compared at baseline, 2 weeks, and 2 months after conversion to determine efficacy, and adverse effect occurrence was compared between visits to assess safety. RESULTS: Conversion was attempted in 79 subjects; 72 met the criteria for review. Mean baseline, 2-week, and 2-month blood pressures for all subjects were 143/74, 139/72, and 139/73 mm Hg, respectively (p values NS). The number of subjects achieving their goal blood pressure at each assessment visit was similar: 37.5% at baseline, 43.4% at 2 weeks, and 31.9% at 2 months. Thirteen of the 72 subjects discontinued irbesartan due to adverse events. CONCLUSIONS: Irbesartan is an appropriate substitution for valsartan or losartan.

Maintenance of Goal Blood Pressure following Conversion from Lisinopril to Fosinopril

2003 ◽  
Vol 19 (5) ◽  
pp. 266-270
Author(s):  
Maqual R Graham ◽  
Nicole M Allcock ◽  
Cameron C Lindsey
Keyword(s):  
Blood Pressure ◽  
Goal Attainment ◽  
Prospective Observational Study ◽  
Goal Blood Pressure ◽  
Assessment Visit ◽  
Blood Pressures ◽  
Blood Pressure Goals ◽  
The Mean ◽  
Medical Histories ◽  
Prescribing Information

Objective: To determine whether blood pressure could be maintained for patients on lisinopril following conversion to a theorized, therapeutic dose of fosinopril. The tolerability of fosinopril was also assessed. Methods: Subjects receiving lisinopril were considered candidates for this prospective, observational study. Prescribing information for both lisinopril and fosinopril suggested a milligram-to-milligram equivalency. Patients taking lisinopril 10 mg/d were switched to fosinopril 10 mg/d. Blood pressures were compared at baseline and 2, 6, and 18 weeks after conversion. A goal blood pressure of <140/90 mm Hg was assigned to all patients at enrollment and used to determine goal attainment at baseline and 18 weeks. More aggressive blood pressure goals are currently recommended; thus, medical histories were reevaluated at the end of the study and new goals were assigned and assessed. Adverse effect occurrence was also compared between visits. Results: One hundred thirty-three subjects were enrolled. The mean dose of lisinopril prior to conversion was 15 ± 11 mg/d compared with the mean final fosinopril dose of 20 ± 14 mg/d. Both the mean systolic and diastolic blood pressures increased significantly at the 18-week visit when compared with baseline (p = 0.00007 and p = 0.015, respectively). Using a goal blood pressure of <140/90 mm Hg, there was no difference detected between the baseline and the final assessment visit (p = 0.851). A greater number of subjects were unable to achieve goal status at 18 weeks when compared with baseline after applying the newly defined goals (p = 0.003). Sixteen of the original 133 subjects discontinued fosinopril due to adverse events. Conclusions: When converting subjects from lisinopril to fosinopril, equivalent blood pressure may be difficult to achieve without increasing the dose of fosinopril.

Testing the health literacy of twenty Bangladeshi patients before and 5 months after they begin to access their GP electronic record

2018 ◽  
Vol 68 (suppl 1) ◽  
pp. bjgp18X697133
Author(s):  
Richard Fitton ◽  
Amir Hannan ◽  
Ingrid Brindle ◽  
Shafia Begum ◽  
Sarwar Shah
Keyword(s):  
Health Literacy ◽  
Health Outcomes ◽  
Medical History ◽  
Medical Records ◽  
Practice Nurse ◽  
Electronic Record ◽  
Phone Calls ◽  
Before And After ◽  
Medical Histories ◽  
Memory Knowledge

BackgroundPatients with higher health literacy enjoy better health outcomes and are more compliant with treatment. Health literacy is a product of memory, reason and imagination. Patients who can access their records have potentially more memory (knowledge) and make less phone calls to and have less consultations with their GP, practice nurse, HCA and other professionals.AimThe study aims to measure the knowledge that twenty Bangladeshi patients with poor English have of their medical history before and after access to their electronic record.Method55% of patients at Thornley House have access to their medical records. A simple questionnaire was given to 20 Bangladeshi patients before and 5 months after access to their electronic record. The questionnaires recorded the patients’ knowledge of their medical histories. The scores of the completed before and after questionnaires were compared to see if record access had increased patients’ knowledge.ResultsFive patients completed before and after questionnaires. Each achieved a higher score after record access. The differences in scores for the five patients were 2, 5, 1, 10, and 1, respectively.ConclusionHealth literacy for patients is similar to medical literacy for doctors. It requires knowledge, skills and attitudes. We will see whether record access can increase knowledge. Further studies might measure whether that increased knowledge improves skills and attitudes.

Abstract WMP57: Declining Blood Pressure is Associated with Subcortical Microinfarcts in Older Adults

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Mekala R Raman ◽  
Jonathan Graff-Radford ◽  
Scott A Przybelski ◽  
Timothy G Lesnick ◽  
Michelle M Mielke ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Elderly Population ◽  
Adult Population ◽  
Blood Pressure Measurement ◽  
The Elderly ◽  
Pressure Measurements ◽  
Autopsy Study ◽  
Cross Sectional ◽  
Blood Pressures

Hypertension is highly prevalent in the elderly population and microinfarcts are the most common vascular brain pathology identified in older adults at autopsy. We investigated the associations between systolic and diastolic blood pressures measured antemortem and the presence of microinfarcts at autopsy. Study subjects (n=302; age range=71-95) were participants in the population-based Mayo Clinic Study of Aging autopsy study, who had blood pressure measurements recorded during life. We investigated both cross-sectional systolic and diastolic blood pressure measurements at the baseline visit and the change in blood pressure (slope). Presence and location (subcortical or cortical) of chronic microinfarcts was abstracted from the autopsy reports. Of the 302 study subjects, 47 (16%) had cerebral microinfarcts, and, of those, 18 (38%) had subcortical microinfarcts and 29 (62%) had only cortical microinfarcts. The baseline blood pressures were not different between subjects with no microinfarcts, subcortical microinfarcts, and only cortical microinfarcts. In a logistic regression model including time between last blood pressure measurement and death, a greater decline in systolic [OR= 1.06 (1.01, 1.11); p=0.02]) and greater decline in diastolic [OR= 1.11 (1.02, 1.20); p=0.01] blood pressures were predictors of the presence of subcortical microinfarcts at autopsy. However, these variables were not associated with the presence of cortical microinfarcts. In conclusion, microinfarcts are common in the older adult population, and most of them are located in the cortex. A greater decline in both systolic and diastolic blood pressures and their association with subcortical microinfarcts, but not with cortical microinfarcts, may have implications for aggressive lowering of blood pressure in the elderly population.

scholarly journals PO-186 Effects of Shaolin Ba Duan Jin on Hypertensive Patients

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Xianfeng Hua
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Heart Rate ◽  
Martial Arts ◽  
Hypertensive Patients ◽  
Quality Of Life Scale ◽  
Before And After ◽  
Life Scale ◽  
Blood Pressures

Objective To investigate the effects of Shaolin Ba Duan Jin on patients with hypertension. Methods In the hypertensive patients detected in the national physical fitness test of public officials in Guiyang City, 40 patients with hypertension were selected. The experiment was started after Shaolin Ba Duan Jin has been practiced for seven days and the subjects had learned it. Experimental method: Frequency of subjects practicing Ba Duan Jin is 7 days a week, subjects practice once a day, practicing time is 6:00-7:30 am or 18:00 -19:30 pm, practicing lasts 1.5 hours each time (practicing has 3 groups, 14 minutes in each group；subjects rest 2 minutes between groups,；preparing part is 8 minutes；ending part is 5 minutes), record the blood pressure of the subjects before and after each experiment, and fill in the quality of life scale (WHOQOL-BREF scale) regularly for a period of 12 weeks. Questionnaire method: Fill in the quality of life scale every three weeks and measure heart rate and blood pressure before and after each exercise. Mathematical statistics: The paired sample t test was used to analyze the changes in blood pressure before and after the 12-week experiment. Results 1) The systolic and diastolic blood pressures of the subjects were significantly lower than before the experiment (P <0.01). 2) The WHOQOL-BREF scale after 12 weeks has improved significantly in all areas than before the experiment. Conclusions 1) Martial arts Ba Duan Jin has a good influence on the circulatory system of hypertensive patients. The performance is that the heart rate is slow and the systolic and diastolic blood pressures have a downward trend. 2) Martial arts Ba Duan Jin has significant improvement in the physiology, psychology, social relations, environment and other fields .

CALCULATION OF CARDIAC OUTPUT FROM BLOOD PRESSURE MEASUREMENTS BEFORE AND AFTER MEALS

1936 ◽  
Vol 116 (3) ◽  
pp. 551-562 ◽  
Author(s):  
H. C. Bazett ◽  
J. C. Scott ◽  
M. E. Maxfield ◽  
M. D. Blithe
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Pressure Measurements ◽  
Before And After

Renal prostanoids after unclipping the denervated one-kidney, one-clip hypertensive rat

1985 ◽  
Vol 249 (4) ◽  
pp. F542-F545 ◽  
Author(s):  
R. Vandongen ◽  
H. McGowan ◽  
H. Anderson ◽  
A. Barden
Keyword(s):  
Blood Pressure ◽  
Neural Mechanisms ◽  
Renal Nerves ◽  
Minor Role ◽  
Similar Extent ◽  
Before And After ◽  
Blood Pressures ◽  
A Minor ◽  
Prostanoid Synthesis ◽  
Stimulation Of

The contribution of the renal nerves in maintaining blood pressure and modulating renal prostanoid synthesis was examined in established (less than 8 wk in duration) one-kidney, one-clip (1K,1C) hypertension in the rat. Systolic blood pressure was measured for 7 days after renal denervation, at which time the renal artery clip was removed. Twenty-four-hour urinary excretion of PGE2 and 6-keto-PGF1 alpha (stable degradation product of PGI2) was determined before and after denervation and unclipping. Compared with sham-denervated rats, denervation (n = 15) resulted in a small but significant fall in blood pressure (from 216 +/- 4 to 182 +/- 4 mmHg after 48 h) and an increase in urinary 6-keto-PGF1 alpha (from 31 +/- 4 to 43 +/- 5 ng/24 h after 24 h). There was no change in PGE2 excretion. Seven days after surgery, blood pressures were similar in denervated (202 +/- 4 mmHg) and sham-denervated (211 +/- 5 mmHg) rats and fell to a similar extent 24 h after unclipping (142 +/- 3 and 147 +/- 4 mmHg, respectively). Urinary 6-keto-PGF1 alpha increased from 25 +/- 5 to 74 +/- 11 in denervated and 21 +/- 2 to 72 +/- 9 ng/24 h in sham-denervated rats in the 24 h after unclipping. PGE2 excretion increased approximately twofold over this period. These findings indicate that the renal nerves have only a minor role in established hypertension in the 1K,1C rat and that the reversal of hypertension and stimulation of renal prostanoid synthesis following unclipping is not dependent on neural mechanisms.

Blood Pressure Parameters as Determinants of Small Artery Structure in Human Essential Hypertension

1997 ◽  
Vol 92 (6) ◽  
pp. 551-557 ◽  
Author(s):  
Anne Cooper ◽  
Anthony M. Heagerty
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Pulse Pressure ◽  
Structural Parameters ◽  
Structural Parameter ◽  
Pressure Measurements ◽  
Significant Determinant ◽  
Small Artery ◽  
Small Arteries ◽  
Blood Pressures

1. Adaptive changes in small arteries may be more closely correlated with pulse pressure than with systolic, diastolic or mean blood pressures in human essential hypertension. 2. An analysis was performed on the structure of small arteries, age and blood pressure measurements obtained from 56 patients with untreated essential hypertension and 56 matched normotensive volunteers to examine the association between age, blood pressure and small artery structural parameters. 3. Essential hypertension was associated with an increase in media thickness and a decrease in lumen diameter, resulting in an increase in media/lumen ratio. 4. There was a significant correlation between age and media/lumen ratio in normotensive volunteers but not in patients with essential hypertension. 5. There was no correlation between any blood pressure and structural parameter in normotensive volunteers. 6. Both diastolic and mean blood pressures in essential hypertension correlated with media/lumen ratio (P < 0.01); systolic blood pressure correlated less well (P < 0.02). However, pulse pressure did not correlate with media/lumen ratio, suggesting that it is not a significant determinant of small artery structure in untreated essential hypertension.

scholarly journals PENGARUH THERAPY BEKAM BASAH TERHADAP TEKANAN DARAH PASIEN HIPERTENSI

2018 ◽  
Vol 6 (2) ◽  
pp. 102-105
Author(s):  
Leli Mulyati
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Cupping Therapy ◽  
Control Group ◽  
Pressure Measurements ◽  
Hypertensive Patients ◽  
Average Systolic Blood Pressure ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental

This study aims to determined the effected of wet cupping therapy on blood pressure in hypertensive patients. The study used a quasi-experimental method with one group pre-test and post-test without a control group. The study subjects total 30 respondents consisting of patients with hypertension. All subjects are given wet cupping treatment twice with an interval of 2 weeks. Blood pressure measurements made ​​before and after wet cupping. The results of analysis used a t-dependent, decrease in average systolic blood pressure was 13 333 ± 12 042 wet cupping mmHg and diastolic 4667 ± 3294 mmHg. At week 2 a decrease in average systolic blood pressure mmHg while the 8667 ± 8308 6667 ± 5525 mmHg diastolic. Decrease in average systolic and diastolic blood pressure there were significant differences (p <0.05) in the first wet cupping and second wet cupping. This shows that wet cupping therapy affects blood pressure in hypertension patients.

scholarly journals EVALUATION OF BLOOD PRESSURE VARIATIONS DURING THE ADMINISTRATION OF INTRAVASCULAR CONTRAST MEDIA IN CECT ABDOMEN

2018 ◽  
Vol 11 (6) ◽  
pp. 309
Author(s):  
Arathy Mary John ◽  
Sushil Yadav
Keyword(s):  
Blood Pressure ◽  
Contrast Media ◽  
Diastolic Blood Pressure ◽  
Repeated Measures ◽  
Sampling Technique ◽  
Ct Scanner ◽  
Abdomen Ct ◽  
Before And After ◽  
Blood Pressures ◽  
Cect Scan

Objective: Hemodynamic changes may occur with the rapid intravenous injection of contrast media due to the osmolality of contrast media. This study is aimed to evaluate the blood pressure variation during the administration of intravascular contrast media in contrast-enhanced computed tomography (CECT) of the abdomen.Methods: The study was performed in 146 subjects, who underwent abdomen CT scan with 64-slice Philips Brilliance CT scanner in the department of radio-diagnosis and imaging. Using convenience sampling technique, 73 subjects who were referred for CECT abdomen scan and another 73 subjects who were referred for non-CECT (NCECT) abdomen scan were included in the study. Among the CECT group, intravascular contrast media was injected into the patient during the scan. Both systolic and diastolic blood pressures were recorded just before and immediately after the scan in CECT and NCECT groups, by two readers independently. Mean systolic and diastolic blood pressure for both groups was calculated with standard deviation. The data were analyzed using repeated measures of ANOVA.Results: Both systolic and diastolic blood pressures increased with the injection of contrast media among CECT scan group. No significant changes in systolic and diastolic blood pressure were found before and after the scan of NCECT group.Conclusion: An increase in both systolic and diastolic blood pressures is associated with the intravascular administration of non-ionic low-osmolar contrast media.

THE FLUSH METHOD FOR DETERMINING BLOOD PRESSURES IN INFANTS

PEDIATRICS ◽  
1958 ◽  
Vol 21 (6) ◽  
pp. 950-957
Author(s):  
Arthur J. Moss ◽  
Wilbert Liebling ◽  
Forrest H. Adams
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Normal Blood ◽  
First Year ◽  
Pressure Measurements ◽  
Normal Blood Pressure ◽  
Chronic Infections ◽  
Arithmetic Means ◽  
Blood Pressures ◽  
The Mean

Observations were made on 551 Caucasian infants from 1 day to 1 year of age. All subjects had normal cardiovascular status and were free from acute or chronic infections. A total of 1,712 measurements of blood pressure were obtained by the flush technique. It is known that measurements made using the flush technique approximate the mean rather than the systolic blood pressure. The values obtained were analyzed in relation to sex, age and body weight. No correlation is found between sex and blood pressure or between body weight within a given monthly age category and blood pressure. Measurements of blood pressure show a pronounced and highly significance rise following the first week of life. During the first 9 months of life the readings are somewhat higher at the wrist than at the ankle. Thereafter, the converse is true. The significance of these findings is discussed. Arithmetic means and the range of normal blood pressure are presented. Exclusive of the first week of life, the range of normal blood pressure during the first year is from 51 to 93 mm Hg for the upper extremity and from 44 to 92 mm Hg for the lower extremity.

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