scholarly journals Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials

2013 ◽  
Vol 34 (2) ◽  
pp. 232-238 ◽  
Author(s):  
Nicole Mayer-Hamblett ◽  
Margaret Kloster ◽  
Bonnie W. Ramsey ◽  
Michael R. Narkewicz ◽  
Lisa Saiman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Clinical Trials ◽  
Liver Function ◽  
Clinical Significance ◽  
Liver Function Tests ◽  
Function Tests ◽  
Elevated Liver Function Tests

Case 4.25

2014 ◽  
pp. 234-235
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Pancreatic Duct ◽  
Liver Function Tests ◽  
Filling Defect ◽  
Distal Common Bile Duct ◽  
Biliary Dilatation ◽  
Function Tests ◽  
Elevated Liver Function Tests

64-year-old man with elevated liver function tests MIP image from 3D FRFSE MRCP (Figure 4.25.1) reveals a filling defect in the distal common bile duct, diffuse intrahepatic biliary dilatation, and mild dilatation of the pancreatic duct. Coronal oblique SSFSE images (Figure ...

Case 3.7

2014 ◽  
pp. 146-146
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Liver Function ◽  
Equilibrium Phase ◽  
Liver Function Tests ◽  
Quadrant Pain ◽  
Function Tests ◽  
Elevated Liver Function Tests ◽  
The Right

80-year-old man with right upper quadrant pain and elevated liver function tests; abdominal US performed at an outside institution showed a mass in the gallbladder Arterial (Figure 3.7.1), portal venous (Figure 3.7.2), and equilibrium phase (Figure 3.7.3) postgadolinium 3D SPGR images demonstrate a hyperenhancing mass within the gallbladder lumen. Note also the large heterogeneous mass seen in the upper pole of the right kidney....

scholarly journals Cystic fibrosis-related liver disease: a single-center experience

2011 ◽  
Vol 3 (3) ◽  
pp. 21 ◽  
Author(s):  
Paula Catarino Costa ◽  
Celeste Canha Barreto ◽  
Luisa Pereira ◽  
Maria Luisa Lobo ◽  
Maria Adília Costa ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Liver Function ◽  
Pediatric Patients ◽  
Liver Function Tests ◽  
Liver Involvement ◽  
Clinical Expression ◽  
Function Tests ◽  
Related Liver Disease

Prospective studies concerning liver disease in pediatric cystic fibrosis patients are scarce. The present study aimed to describe the prevalence and clinical expression of cystic fibrosis - related liver disease, in a cohort of 62 pediatric patients. Descriptive study, resulting from the prospective evaluation, between 1994 and 2009, of 62 pediatric patients (age <18 years) with cystic fibrosis. The follow-up protocol included a clinical assessment every 2 months, liver function tests every 6 months and annual liver ultrasonography. The cumulative prevalence of liver disease was 11.2% (7/62 cases). All patients had ΔF508 mutation and pancreatic insufficiency, none had meconium ileus. The liver involvement became clinically evident at a mean age of 8 years (3-15 years), revealed by hepatomegaly or hepatosplenomegaly (3 cases) and/ or abnormalities of liver function tests (3 cases) changes of liver ultrasound (7 cases) with evidence of portal hypertension (2 cases). Four patients were submitted to liver biopsy; biliary fibrosis was documented in one case, focal biliary cirrhosis in 2 cases and multilobular cirrhosis in another case. Within a median 11.6 years follow-up period (all patients under UDCA therapy after liver disease diagnosis), progression of liver disease was observed in 2 patients; one patient developed refractory variceal bleeding and progressive hepatic failure, requiring liver transplant. The results of the present study agree with those of previous pediatric studies, further documenting clinical expression of liver disease in CF patients, which is usually detected in the first decade of life and emphasize the contribution of ultrasound to early diagnosis of liver involvement. Moreover, although advanced liver disease is a relatively rare event, early isolated liver transplantation may have to be considered at this age group.

scholarly journals EFFECTS OF TAURAIN (T) AND URSODEOXYCHOLIC ACID (UDCA) ON LIVER FUNCTION TESTS IN PATIENTS WITH CYSTIC FIBROSIS

1989 ◽  
Vol 26 (3) ◽  
pp. 278-278
Author(s):  
C Colombo ◽  
M Podda ◽  
A Crosignani ◽  
L Curcio ◽  
M Ronchi ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Function ◽  
Ursodeoxycholic Acid ◽  
Liver Function Tests ◽  
Function Tests
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