Feasibility Study on Rapid Analysis of Doxycycline Hydrochloride Aqueous Solution by Terahertz Time-Domain Spectroscopy

2019 ◽  
Vol 62 (1) ◽  
pp. 205-212
Author(s):  
Yuxin Huang ◽  
Chen Wang ◽  
Jianyuan Qin ◽  
Wendao Xu ◽  
Min Chen ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Time Domain ◽  
Rapid Analysis ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Thz Spectroscopy ◽  
Terahertz Time Domain Spectroscopy ◽  
Transmission Method ◽  
Time Domain Spectroscopy ◽  
Terahertz Transmission

Abstract. Antibiotics have been extensively applied in the treatment of infections in food-producing animals. However, the residues of these agents create a potential risk to human health. Among the methods available for rapid detection of antibiotics, terahertz time-domain spectroscopy (THz-TDS) has emerged as a technique with unique advantages over other methods. In this study, we demonstrate that rapid analysis of doxycycline hydrochloride (DCH) aqueous solutions could be achieved with THz-TDS through transmission, attenuated total reflection (ATR), and reflection with minimum detectable concentrations of 5000, 10, and 80 mg L-1, respectively, indicating that the ATR and reflection methods are superior to the transmission method for low-concentration aqueous solutions. This study is an effort to promote the development of rapid analysis of antibiotic residues in an aqueous matrix using THz spectroscopy. Keywords: Attenuated total reflection, Doxycycline hydrochloride solution, Reflection, Terahertz, Transmission.

scholarly journals Salt effects on the picosecond dynamics of lysozyme hydration water investigated by terahertz time-domain spectroscopy and an insight into the Hofmeister series for protein stability and solubility

2016 ◽  
Vol 18 (22) ◽  
pp. 15060-15069 ◽  
Author(s):  
Katsuyoshi Aoki ◽  
Kentaro Shiraki ◽  
Toshiaki Hattori
Keyword(s):  
Aqueous Solutions ◽  
Protein Stability ◽  
Time Domain ◽  
Protein Solubility ◽  
Hydration Water ◽  
Hofmeister Series ◽  
Terahertz Time Domain Spectroscopy ◽  
Salt Effects ◽  
Time Domain Spectroscopy ◽  
Insight Into

The addition of salts into protein aqueous solutions causes changes in protein solubility and stability, the ability of which is known to be ordered in the Hofmeister series.

Low-frequency dynamics of proteins and aqueous solutions studied by terahertz time-domain spectroscopy

2013 ◽  
Author(s):  
Naoki Yamamoto ◽  
Akané Ishihara ◽  
Azusa Kaneko ◽  
Haruka Iguchi ◽  
Ohki Kambara ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Time Domain ◽  
Low Frequency ◽  
Terahertz Time Domain Spectroscopy ◽  
Time Domain Spectroscopy

scholarly journals Relationships between Molecular Structure of Carbohydrates and their Dynamic Hydration Shells Revealed by Terahertz Time-Domain Spectroscopy

2021 ◽  
Vol 22 (21) ◽  
pp. 11969
Author(s):  
Nikita V. Penkov
Keyword(s):  
Aqueous Solutions ◽  
Time Domain ◽  
Water Structure ◽  
Free Water ◽  
Equatorial Orientation ◽  
Terahertz Time Domain Spectroscopy ◽  
Time Domain Spectroscopy ◽  
Glycosidic Bonds ◽  
Hydration Shells ◽  
Hydrogen Bond Energies

Despite more than a century of research on the hydration of biomolecules, the hydration of carbohydrates is insufficiently studied. An approach to studying dynamic hydration shells of carbohydrates in aqueous solutions based on terahertz time-domain spectroscopy assay is developed in the current work. Monosaccharides (glucose, galactose, galacturonic acid) and polysaccharides (dextran, amylopectin, polygalacturonic acid) solutions were studied. The contribution of the dissolved carbohydrates was subtracted from the measured dielectric permittivities of aqueous solutions based on the corresponding effective medium models. The obtained dielectric permittivities of the water phase were used to calculate the parameters describing intermolecular relaxation and oscillatory processes in water. It is established that all of the analyzed carbohydrates lead to the increase of the binding degree of water. Hydration shells of monosaccharides are characterized by elevated numbers of hydrogen bonds and their mean energies compared to undisturbed water, as well as by elevated numbers and the lifetime of free water molecules. The axial orientation of the OH(4) group of sugar facilitates a wider distribution of hydrogen bond energies in hydration shells compared to equatorial orientation. The presence of the carboxylic group affects water structure significantly. The hydration of polysaccharides is less apparent than that of monosaccharides, and it depends on the type of glycosidic bonds.

scholarly journals Volatile Liquid Detection by Terahertz Technologies

2021 ◽  
Vol 9 ◽  
Author(s):  
Harry W Baxter ◽  
Adam A Worrall ◽  
Jie Pang ◽  
Riqing Chen ◽  
Bin Yang
Keyword(s):  
Time Domain ◽  
Total Reflection ◽  
Thz Spectroscopy ◽  
Low Loss ◽  
Time Domain Spectroscopy ◽  
Liquid Samples ◽  
Volatile Liquid ◽  
Volatile Liquids ◽  
Line Scanner ◽  
2D Images

The prospect of being able to move through security without the inconvenience of separating liquids from bags is an exciting one for passengers, and there are important operational benefits for airports as well. Here, two terahertz (THz) systems, 100 GHz sub-THz line scanner and attenuation total reflection-based THz time domain spectroscopy (TDS), have been used to demonstrate the capability of identifying different liquid samples. Liquid samples’ THz complex permittivities are measured and their differences have contributed to the variation of 100 GHz 2D images of volatile liquids with different volumes inside of cannister bottles. The acquired attenuation images at 100 GHz can easily be used to distinguish highly absorbed liquids (Water, Ethanol, Fuel Treatment Chemicals) and low loss liquids (Petrol, Diesel, Kerosene and Universal Bottle Cleaner). The results give a promising feasibility for mm-wave imager and THz spectroscopy to efficiently identify different volatile liquids.

Sign in / Sign up

Export Citation Format

Share Document