Synthesis and Evaluation of Some 2–Aryl–3–[Substituted Pyridin–2–Yl]-Amino/Methylamino Thiazolidin-4-Ones

A series of compounds incorporating thiazolidinone moiety has been synthesized and screened for their antifungal activity. 2-Aryl-3-[substituted pyridin-2-yl]-amino/methylamino thiazolidin-4-ones have been synthesized by cyclocondensation of [substituted pyridin-2-yl]- araldehydehydrazone and N-Methyl [substituted pyridin-2-yl]-araldehydehydrazone with mercapto acetic acid in dioxane. The initial reactants required for the synthesis were obtained by refluxing 2-hydrazino substituted pyridine and 2-[N-methylhydrazino]-substituted pyridine with different substituted aldehydes. These newly synthesized compounds were then screened for their fungicidal activity against Rhizoctina solani and Fusarium oxysporum. Structures of all these compounds were confirmed by 1H NMR, IR and mass spectrum analysis. Some compounds exhibited excellent fungicidal properties.