scholarly journals Development and Validation of Hplc-Ms/Ms Method for Rivaroxaban Quantitation in Human Plasma Using Solid Phase Extraction Procedure

2015 ◽  
Vol 32 (2) ◽  
pp. 1145-1154 ◽  
Author(s):  
G Reddy ◽  
S. L. N Prasad ◽  
L. Shiva Kumar
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Extraction Procedure ◽  
Phase Extraction ◽  
Solid Phase Extraction Procedure ◽  
Development And Validation

HPLC analysis of the novel antidepressant duloxetine in human plasma after an original solid-phase extraction procedure

2007 ◽  
Vol 856 (1-2) ◽  
pp. 81-87 ◽  
Author(s):  
Laura Mercolini ◽  
Roberto Mandrioli ◽  
Roberto Cazzolla ◽  
Mario Amore ◽  
Maria Augusta Raggi
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Hplc Analysis ◽  
Solid Phase ◽  
Extraction Procedure ◽  
Phase Extraction ◽  
The Novel ◽  
Solid Phase Extraction Procedure

scholarly journals Uniform solid-phase extraction procedure for toxicological drug screening in serum and urine by HPLC with photodiode-array detection

1997 ◽  
Vol 43 (2) ◽  
pp. 312-325 ◽  
Author(s):  
Chi-Kong Lai ◽  
Ting Lee ◽  
Kam-Ming Au ◽  
Albert Yan-Wo Chan
Keyword(s):  
Solid Phase Extraction ◽  
Drug Screening ◽  
Solid Phase ◽  
Extraction Procedure ◽  
Phase Extraction ◽  
Urine Metabolites ◽  
Ultraviolet Spectra ◽  
Solid Phase Extraction Procedure ◽  
Array Detection ◽  
Serum And Urine

Abstract In this HPLC–diode-array detection method for toxicological drug screening, a mixed-mode solid-phase extraction procedure is optimized for isolation of a broad range of drugs from serum and urine. Basic, neutral, and weakly acidic drugs are uniformly recovered. The extract from the solid-phase cartridge is readily injected to a reversed-phase HPLC column for separation by gradient elution. Unknown drugs and metabolites in urine and serum samples from acute drug poisoning cases are rapidly identified by matching their retention times and ultraviolet spectra with hundreds of reference compounds in the library. Urine metabolites of common toxicants from various medications and drugs of abuse are recorded, with their changes of retention times and ultraviolet spectra as related to their metabolic transformations. Glucuronide conjugates of common benzodiazepines, tricyclic antidepressants, and beta-blockers are examined directly without chemical or enzymatic hydrolysis. The system is reliable for diverse clinical investigations of drug overdoses, drug-induced psychoses, and substance abuse.

Sign in / Sign up

Export Citation Format

Share Document