scholarly journals Two-Pore Channels in Cancer Hallmarks: An Update Review

2021 ◽  
Vol 14 (3) ◽  
pp. 1481-1500
Author(s):  
Nelofar Sediqi ◽  
Aisyah Hasyila Jahidin ◽  
Mizaton Hazizul Hasan ◽  
Yuslina Zakaria
Keyword(s):  
Cell Proliferation ◽  
Cancer Therapy ◽  
Calcium Signaling ◽  
Crucial Role ◽  
Calcium Signalling ◽  
Metabolic Reprogramming ◽  
Present Review ◽  
Pore Channel ◽  
Cancer Hallmarks ◽  
Common Criteria

Cancer is one of the most disastrous diseases that leads to a serious threat to millions of people’s health worldwide. Cancer is distinguished by multiple common criteria, known as the “cancer hallmarks" which calcium signaling has either direct or indirect correlation with each of them. An emerging body of evidence suggests that two-pore channels/calcium signaling machinery has a crucial role in the promotion of diverse aspects of cancer, particularly in several cancer hallmarks including cell proliferation, angiogenesis, migration, invasion, metastasis, and metabolic reprogramming. Recent findings linked two-pore channels/calcium signaling machinery with autophagy, chemoresistance, and patients' survival in cancer. The present review provides current findings on the roles of two-pore channels in cancer, particularly in several cancer hallmarks, autophagy, and chemoresistance. Furthermore, a specific focus on recent data concerning the two-pore channels antagonists and novel inhibitors is discussed. This review will furnish readers with a more in-depth understanding of the significance of two-pore channel calcium signalling in cancer and its potential as a druggable target for cancer therapy

scholarly journals The expanded role of fatty acid metabolism in cancer: new aspects and targets

2019 ◽  
Vol 2 (3) ◽  
pp. 183-191 ◽  
Author(s):  
Ming Chen ◽  
Jiaoti Huang
Keyword(s):  
Fatty Acids ◽  
Cell Proliferation ◽  
Lipid Metabolism ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Acid Metabolism ◽  
Metabolic Reprogramming ◽  
Metabolic Plasticity ◽  
Support Cell

Abstract Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming. Recent studies have revealed an expanded range of roles played by FA in promoting the aggressiveness of cancer while simultaneously identifying new potential targets for cancer therapy. This article provides a brief review of these advances in our understanding of FA metabolism in cancer, highlighting both recent discoveries and the inherent challenges caused by the metabolic plasticity of cancer cells in targeting lipid metabolism for cancer therapy.

Modulation of CD44, EGFR and RAC Pathway Genes (WAVE Complex) in Epithelial Cancers

2019 ◽  
Vol 25 (8) ◽  
pp. 833-848
Author(s):  
Pranathi Tata ◽  
Piyush Gondaliya ◽  
Aditya Sunkaria ◽  
Akshay Srivastava ◽  
Kiran Kalia
Keyword(s):  
Cell Proliferation ◽  
Receptor Tyrosine Kinase ◽  
Crucial Role ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Biology ◽  
Mesenchymal Transition ◽  
Epithelial Cancers ◽  
Cancer Hallmarks ◽  
Proliferation And Invasion ◽  
Wave Complex

Cancer hallmarks help in understanding the diversity of various neoplasms. Epithelial cancers play an immense role in the tumor biology through Epithelial-Mesenchymal Transition (EMT) process. Receptor tyrosine kinase, as well as phosphatidyl ionositol-3 kinase pathways, play an important role in the regulation of cell proliferation, survival, and differentiation during EMT. Till date, numerous studies have shown modulation in the expression profile of potential targets like CD44, EGFR, and Rac in epithelial cancers. CD44 interacts with EGFR and recruits other molecules which further activate the Rac pathway intermediates. This review mainly focused on modulation of genes like CD44, EGFR, and Rac pathway intermediates which play a crucial role in the tumor progression, metastasis, proliferation, and invasion characteristics in epithelial cancers with EMT properties. Hence, targeting Rac pathway might be a more strategically relevant approach in treating epithelial cancers.

Promising Anticancer Therapeutics From Mushrooms: Current Findings and Future Perceptions

2020 ◽  
Vol 21 ◽  
Author(s):  
Mrunmaya Kumar Panda ◽  
Manish Paul ◽  
Sameer Kumar Singdevsachan ◽  
Kumananda Tayung ◽  
Swagat Kumar Das ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
In Silico ◽  
Present Review ◽  
Cancer Cell Proliferation ◽  
Research Papers ◽  
Medicinal Mushrooms ◽  
In Silico Studies ◽  
Anticancer Therapeutics ◽  
Ethnomedicinal Uses

Background: Nowadays medicines derived from natural sources have drawn much attention as potential therapeutic agents in the suppression and treatment of cancer because of their low toxicity and fewer side effects. Objective: The present review aims to assess the currently available knowledge on the ethnomedicinal uses and pharmacological activities of bioactive compounds obtained from medicinal mushrooms towards cancer treatment. Methods: Literature search has been conducted for the collection of research papers from universally accepted scientific databases. These research papers and published book chapters were scrutinized to retrieve information on ethnomedicinal uses of mushrooms, different factors involved in cancer cell proliferation, clinical and in silico pharmaceutical studies made for possible treatments of cancer using mushroom derived compounds. Overall 241 articles were retrieved and reviewed from the year of 1970 to 2020, out of which 98 relevant articles were finally considered for preparation of this review. Results: This review presents an update on the natural bioactive substances derived from medicinal mushrooms and their role in inhibiting the factors responsible for cancer cell proliferation. Along with it, the present review also provides information on the ethnomedicinal uses, solvents used for extraction of anticancer metabolites, clinical trials, and in silico studies that were undertaken towards anticancer drug development from medicinal mushrooms. Conclusion: The present review provides an extensive knowledge on various anticancer substances obtained from medicinal mushrooms, their biological actions and in silico drug designing approaches which could form a basis for the development of natural anticancer therapeutics.

scholarly journals Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 359
Author(s):  
Hsiang-Hao Chuang ◽  
Yen-Yi Zhen ◽  
Yu-Chen Tsai ◽  
Cheng-Hao Chuang ◽  
Ming-Shyan Huang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Suppressors ◽  
Protein Conformation ◽  
Genome Stability ◽  
Recent Progress ◽  
Multiple Roles ◽  
Cancer Development ◽  
Cancer Hallmarks ◽  
Underlying Mechanisms ◽  
And Function

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity.

scholarly journals A light-controlled multi-step drug release nanosystem targeting tumor hypoxia for synergistic cancer therapy

2021 ◽  
Author(s):  
Bin Zhang ◽  
Zichen Xu ◽  
Wen Zhou ◽  
Zhikun Liu ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Therapy ◽  
Drug Release ◽  
Distant Metastasis ◽  
Tumor Hypoxia ◽  
Treatment Resistance ◽  
Major Obstacle

Hypoxia is a major obstacle for cancer therapy due to its association with cell proliferation, tumor distant metastasis, and treatment resistance. In this study, a hypoxia-activated bifunctional prodrug (CC5) was...

scholarly journals Metabolic reprogramming and epigenetic modifications on the path to cancer

2021 ◽  
Author(s):  
Linchong Sun ◽  
Huafeng Zhang ◽  
Ping Gao
Keyword(s):  
Immune Cells ◽  
Immune Escape ◽  
Epigenetic Modification ◽  
Epigenetic Modifications ◽  
Metabolic Reprogramming ◽  
Epigenetic Alterations ◽  
Metabolic Alterations ◽  
Cancer Hallmarks ◽  
Epigenetic Remodeling ◽  
Spatial Regionalization

AbstractMetabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regionalization of enzymes or metabolites. Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations, in particular the acetylation and methylation of histone proteins and DNA. We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in metabolism- and epigenetic modification-based therapeutic prospects in cancer.

scholarly journals Targeting calcium signaling in cancer therapy

2017 ◽  
Vol 7 (1) ◽  
pp. 3-17 ◽  
Author(s):  
Chaochu Cui ◽  
Robert Merritt ◽  
Liwu Fu ◽  
Zui Pan
Keyword(s):  
Cancer Therapy ◽  
Calcium Signaling

Knockdown of PGM1 Synergistically Enhances Anticancer Effects of Orlistat in Gastric Cancer Under Glucose Deprivation

2021 ◽  
Author(s):  
Bo Cao ◽  
Huan Deng ◽  
Hao Cui ◽  
Ruiyang Zhao ◽  
Hanghang Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Lipid Metabolism ◽  
Fatty Acid Synthase ◽  
Enrichment Analysis ◽  
Glucose Deprivation ◽  
Metabolic Reprogramming ◽  
The Cancer Genome Atlas

Abstract Background Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop novel regimens based on metabolic reprogramming in GC. MethodsCorrelation and enrichment analysis of PGM1 was conducted based on The Cancer Genome Atlas database. Data derived from the Kaplan-Meier Plotter database were analyzed for correlations between PGM1 expression and survival time of GC patients. CCK-8, EdU, flow cytometry assays, generation of subcutaneous tumor and lung metastasis mouse models were used to determine growth and metastasis in vitro and in vivo. Cell glycolysis was detected by a battery of glycolytic indicators, including lactate, pyruvic acid, ATP production and glucose uptake. Fatty Acid Synthase (FASN) activity and detection of lipid regulators levels by western blot were used to reflect on the cell lipid metabolism. ResultsCorrelation and enrichment analysis suggested that PGM1 was closely associated with cell proliferation and metabolism. PGM1 was overexpressed in GC tissues and cell lines. High PGM1 expression served as an indicator of shorter survival for specific subpopulation of GC patients, which was also correlated with some clinicopathological features, including T stage and TNM stage. Under low glucose conditions, knockdown of PGM1 significantly suppressed cell proliferation and glycolysis levels, whereas lipid metabolism was enhanced. Orlistat, as a drug that was designed to inhibit FASN activity for obesity treatment, effectively induced apoptosis, suppressed FASN activity. However, orlistat conversely increased glycolytic levels in GC cells. Orlistat exhibited more significant inhibitive effects on GC progression after knockdown of PGM1 under glucose deprivation due to combination of glycolysis and lipid metabolism. ConclusionsDownregulation of PGM1 expression under glucose deprivation synergistically enhanced anti-cancer effects of orlistat. This combination application may serve as a novel strategy for GC treatment.

scholarly journals Active targeting of nanoparticles: An innovative technology for drug delivery in cancer therapeutics

2019 ◽  
Vol 9 (1-s) ◽  
pp. 408-415 ◽  
Author(s):  
Rupalben Kaushalkumar Jani ◽  
Gohil Krupa
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Active Targeting ◽  
Innovative Technology ◽  
Cross Linking ◽  
Uncontrolled Cell Proliferation ◽  
Insight Into

In nanomedicines, currently a wide array of reported nanoparticle systems is being explored by targeting schemes which suggests great potential of targeted delivery to revolutionize cancer therapeutics. This review  gives insight into recent  challenges in modification of nanoparticle systems for enhanced cancer therapy  acknowledged by researchers to date and also outlines different major targeting strategies of nanoparticle systems that have been utilized for the delivery of therapeutics or imaging agents, targeting ligand and cross-linking agent to cancer  which was divided into three sections: 1) Angiogenesis associated targeting, 2) Uncontrolled cell proliferation targeting and 3) Tumor cell targeting. Keywords: nanoparticles, tumor cells, active targeting, targeting strategies, targeting ligands

PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1

2007 ◽  
Vol 101 (4) ◽  
pp. 969-978 ◽  
Author(s):  
Weiming Ouyang ◽  
Jingxia Li ◽  
Dongyun Zhang ◽  
Bing-Hua Jiang ◽  
Dr Chuanshu Huang
Keyword(s):  
Cell Proliferation ◽  
Cyclin D1 ◽  
Crucial Role ◽  
Human Keratinocytes ◽  
Signal Pathway
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