scholarly journals Targeting calcium signaling in cancer therapy

2017 ◽  
Vol 7 (1) ◽  
pp. 3-17 ◽  
Author(s):  
Chaochu Cui ◽  
Robert Merritt ◽  
Liwu Fu ◽  
Zui Pan
Keyword(s):  
Cancer Therapy ◽  
Calcium Signaling

scholarly journals Two-Pore Channels in Cancer Hallmarks: An Update Review

2021 ◽  
Vol 14 (3) ◽  
pp. 1481-1500
Author(s):  
Nelofar Sediqi ◽  
Aisyah Hasyila Jahidin ◽  
Mizaton Hazizul Hasan ◽  
Yuslina Zakaria
Keyword(s):  
Cell Proliferation ◽  
Cancer Therapy ◽  
Calcium Signaling ◽  
Crucial Role ◽  
Calcium Signalling ◽  
Metabolic Reprogramming ◽  
Present Review ◽  
Pore Channel ◽  
Cancer Hallmarks ◽  
Common Criteria

Cancer is one of the most disastrous diseases that leads to a serious threat to millions of people’s health worldwide. Cancer is distinguished by multiple common criteria, known as the “cancer hallmarks" which calcium signaling has either direct or indirect correlation with each of them. An emerging body of evidence suggests that two-pore channels/calcium signaling machinery has a crucial role in the promotion of diverse aspects of cancer, particularly in several cancer hallmarks including cell proliferation, angiogenesis, migration, invasion, metastasis, and metabolic reprogramming. Recent findings linked two-pore channels/calcium signaling machinery with autophagy, chemoresistance, and patients' survival in cancer. The present review provides current findings on the roles of two-pore channels in cancer, particularly in several cancer hallmarks, autophagy, and chemoresistance. Furthermore, a specific focus on recent data concerning the two-pore channels antagonists and novel inhibitors is discussed. This review will furnish readers with a more in-depth understanding of the significance of two-pore channel calcium signalling in cancer and its potential as a druggable target for cancer therapy

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Tetracycline Resolves Cancer Therapy Rash

2007 ◽  
Vol 37 (14) ◽  
pp. 23
Author(s):  
KERRI WACHTER
Keyword(s):  
Cancer Therapy
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