scholarly journals Role of designed Bio-Geometrical forms in antagonizing neurobehavioral burden of Wi-Fi radiation: Evidence-based experimental study

2019 ◽  
Vol 12 (3) ◽  
pp. 1217-1234
Author(s):  
Nevin E. Sharaf ◽  
Asmaa F. Galal ◽  
Mohamed S. El-Sawy ◽  
Aziza B. Shalby ◽  
Alaa H. Sayed ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Task ◽  
Anxiety Level ◽  
Control Group ◽  
Hsp 70 ◽  
Brain Areas ◽  
Wireless Router ◽  
Geometrical Shapes ◽  
The Impact

This study investigated the impact of Wi-Fi signals exposure on cognitive function and its relevant brain biomarkers and the possible role of designed Bio-Geometrical forms in restoring the neurobehavioral alterations resulting from the exposure to the emerging radiation.Rats were assigned into 3 groups; Gp I control group (away from exposure to radiation); Gp II, III were exposed to wireless router signals for 24 h for 6 months and Gp III was protected by a set of designed BioGeometrical shapes. Animals were tested for spatial memory, anxiety and emotionality in addition to the related neurotransmitters (dopamine, serotonin and acetylcholine) in different brain areas. Melatonin, Heat Shock Protein (HSP-70) and acetylcholine esterase (AchE) were also measured in various brain regions and histopathological examination was carried out as well. Wi-Fi radiation exposed group showed elevated anxiety level and impaired spatial memory. Moreover, significant decline in dopamine, serotonin and acetylcholine levels in the investigated brain areas has been recorded. Melatonin levels were decreased in the cortex, striatum and hippocampus while HSP-70 was depleted in the cortex only. Using Bio-Geometrical forms along with Wi-Fi exposure could combat the burden of Wi-Fi radiation. This was evidenced by the recovery of the anxiety level and the improvement of memory task. In addition, the presence of Bio-Geometrical shapes could retrieve dopamine, serotonin and acetylcholine as well as melatonin and HSP-70 levels This study provides solid foundation for the potential use of Bio-Geometrical shapes to modify the insult of Wi-Fi radiation on brain function and structure.

The Use of Posterior Pericardiotomy Technique to Prevent Postoperative Pericardial Effusion in Cardiac Surgery

2012 ◽  
Vol 15 (2) ◽  
pp. 84 ◽  
Author(s):  
Canturk Cakalagaoglu ◽  
Cengiz Koksal ◽  
Ayse Baysal ◽  
Gokhan Alici ◽  
Birol Ozkan ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Heart Surgery ◽  
Artery Bypass ◽  
Pericardial Tamponade ◽  
Anxiety Level ◽  
Control Group ◽  
Echocardiographic Study ◽  
Number Of Patients ◽  
Hospital Stays

<p><b>Aim:</b> The goal was to determine the effectiveness of the posterior pericardiotomy technique in preventing the development of early and late pericardial effusions (PEs) and to determine the role of anxiety level for the detection of late pericardial tamponade (PT).</p><p><b>Materials and Methods:</b> We divided 100 patients randomly into 2 groups, the posterior pericardiotomy group (n = 50) and the control group (n = 50). All patients undergoing coronary artery bypass grafting surgery (CABG), valvular heart surgery, or combined valvular and CABG surgeries were included. The posterior pericardiotomy technique was performed in the first group of 50 patients. Evaluations completed preoperatively, postoperatively on day 1, before discharge, and on postoperative days 5 and 30 included electrocardiographic study, chest radiography, echocardiographic study, and evaluation of the patient's anxiety level. Postoperative causes of morbidity and durations of intensive care unit and hospital stays were recorded.</p><p><b>Results:</b> The 2 groups were not significantly different with respect to demographic and operative data (<i>P</i> > .05). Echocardiography evaluations revealed no significant differences between the groups preoperatively; however, before discharge the control group had a significantly higher number of patients with moderate, large, and very large PEs compared with the pericardiotomy group (<i>P</i> < .01). There were 6 cases of late PT in the control group, whereas there were none in the pericardiotomy group (<i>P</i> < .05). Before discharge and on postoperative day 15, the patients in the pericardiotomy group showed significant improvement in anxiety levels (<i>P</i> = .03 and .004, respectively). No differences in postoperative complications were observed between the 2 groups.</p><p><b>Conclusion:</b> Pericardiotomy is a simple, safe, and effective method for reducing the incidence of PE and late PT after cardiac surgery. It also has the potential to provide a better quality of life.</p>

scholarly journals Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3578
Author(s):  
Federica Mastroiacovo ◽  
Francesca Biagioni ◽  
Paola Lenzi ◽  
Larisa Ryskalin ◽  
Stefano Puglisi-Allegra ◽  
...  
Keyword(s):  
Direct Evidence ◽  
Neuronal Survival ◽  
Hsp 70 ◽  
Preclinical Models ◽  
Brain Areas ◽  
Cell Compartments ◽  
Control Brain ◽  
Disease Modifier ◽  
Subcellular Compartmentalization

The heat shock protein (HSP) 70 is considered the main hallmark in preclinical studies to stain the peri-infarct region defined area penumbra in preclinical models of brain ischemia. This protein is also considered as a potential disease modifier, which may improve the outcome of ischemic damage. In fact, the molecule HSP70 acts as a chaperonine being able to impact at several level the homeostasis of neurons. Despite being used routinely to stain area penumbra in light microscopy, the subcellular placement of this protein within area penumbra neurons, to our knowledge, remains undefined. This is key mostly when considering studies aimed at deciphering the functional role of this protein as a determinant of neuronal survival. The general subcellular placement of HSP70 was grossly reported in studies using confocal microscopy, although no direct visualization of this molecule at electron microscopy was carried out. The present study aims to provide a direct evidence of HSP70 within various subcellular compartments. In detail, by using ultrastructural morphometry to quantify HSP70 stoichiometrically detected by immuno-gold within specific organelles we could compare the compartmentalization of the molecule within area penumbra compared with control brain areas. The study indicates that two cell compartments in control conditions own a high density of HSP70, cytosolic vacuoles and mitochondria. In these organelles, HSP70 is present in amount exceeding several-fold the presence in the cytosol. Remarkably, within area penumbra a loss of such a specific polarization is documented. This leads to the depletion of HSP70 from mitochondria and mostly cell vacuoles. Such an effect is expected to lead to significant variations in the ability of HSP70 to exert its physiological roles. The present findings, beyond defining the neuronal compartmentalization of HSP70 within area penumbra may lead to a better comprehension of its beneficial/detrimental role in promoting neuronal survival.

scholarly journals Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Clara Saad Menezes ◽  
Alicia Dudy Müller Veiga ◽  
Thais Martins de Lima ◽  
Suely Kunimi Kubo Ariga ◽  
Hermes Vieira Barbeiro ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Peripheral Blood ◽  
World Health ◽  
Control Group ◽  
Pyrin Domain ◽  
Peripheral Blood Gene Expression ◽  
Severe Group ◽  
Health Organization ◽  
The Impact

AbstractThe role of innate immunity in COVID-19 is not completely understood. Therefore, this study explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on the expression of Pattern Recognition Receptors (PRRs) in peripheral blood cells and their correlated cytokines. Seventy-nine patients with severe COVID-19 on admission, according to World Health Organization (WHO) classification, were divided into two groups: patients who needed mechanical ventilation and/or deceased (SEVERE, n = 50) and patients who used supplementary oxygen but not mechanical ventilation and survived (MILD, n = 29); a control group (CONTROL, n = 17) was also enrolled. In the peripheral blood, gene expression (mRNA) of Toll-like receptors (TLRs) 3, 4, 7, 8, and 9, retinoic-acid inducible gene I (RIGI), NOD-like receptor family pyrin domain containing 3 (NLRP3), interferon alpha (IFN-α), interferon beta (IFN-β), interferon gamma (IFN-γ), interferon lambda (IFN-λ), pro-interleukin(IL)-1β (pro-IL-1β), and IL-18 was determined on admission, between 5–9 days, and between 10–15 days. Circulating cytokines in plasma were also measured. When compared to the COVID-19 MILD group, the COVID-19 SEVERE group had lower expression of TLR3 and overexpression of TLR4.

ANTICIPATORY ABILITY OF COACHES IN THE SYSTEM OF THEIR PROFESSIONAL COMPETENCE EVALUATION BY ATHLETES

2020 ◽  
Vol 8 (3) ◽  
pp. 103-111
Author(s):  
Lusine Stepanyan
Keyword(s):  
Work Experience ◽  
Personal Development ◽  
Professional Competence ◽  
Control Group ◽  
Test Results ◽  
Perceptual Evaluation ◽  
Competence Evaluation ◽  
The Subject ◽  
The Impact

Current research in psychology and psychophysiology focuses on the subject of anticipation and forecasting. Anticipatory sustainability is a personal trait that determines the ability to anticipate events and possible ways of personal development, as well as the ability to prevent interpersonal conflicts. The aim of the study was to identify the role of development level of anticipatory competence of coaches in their professional competence evaluation and perception by athletes. Research methods and organization. The research involved two groups of test subjects. The experimental group consisted of sport dance coaches and their students. The control group brought together experts in socionomic area with different work experience. We used testing and questionnaire methods to achieve the goal and objectives of the study. Testing method included the test for diagnosing anticipatory sustainability according to A. Mendelevich and the test of socio-perceptual coaching evaluation by athletes. We used the results of testing and questionnaires to provide a comparative and correlation analysis of data. Research results. The analysis of test results revealed the impact of work experience on the development of both spatial and temporal characteristics of the anticipation of coaches, indicating a possible effect on the intensity and direction of development of those characteristics in specific conditions. We have identified valid connections between the gnostic parameter (professional competence evaluation) of the socio-perceptual coaching evaluation by athletes and spatiotemporal characteristics of coaches' anticipation, defined as professionally important qualities of coaches. Moreover, we have demonstrated a weak direct relationship between the personality-situational component of the anticipatory sustainability of coaches and the emotional parameter of their socio-perceptual evaluation by athletes, indicating a significant role of communicative-anticipation sustainability in the development of an attitude of athletes to the coach. Conclusion. In summary, we can conclude that the anticipatory sustainability of coaches plays a key role in the structure of their competence, and the development of this property is possible under certain conditions.

Theta power and theta-gamma coupling support spatial memory retrieval

2019 ◽  
Author(s):  
Umesh Vivekananda ◽  
Daniel Bush ◽  
James A Bisby ◽  
Sallie Baxendale ◽  
Roman Rodionov ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Task Performance ◽  
Memory Function ◽  
Memory Task ◽  
Theta Oscillations ◽  
Theta Power ◽  
Human Epilepsy ◽  
Phase Amplitude ◽  
Hippocampal Theta

AbstractHippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations during spatial memory function, and how this relates to subsequent behaviour. Here we asked ten human epilepsy patients undergoing intracranial EEG recording to perform a desk-top virtual reality spatial memory task, and found that increased theta power in two discrete bands (‘low’ 2-5Hz and ‘high’ 6-9Hz) during cued retrieval was associated with improved task performance. Similarly, increased coupling between ‘low’ theta phase and gamma amplitude during the same period was associated with improved task performance. These results support a role of theta oscillations and theta-gamma phase-amplitude coupling in human spatial memory function.

scholarly journals The Effect of Fixed-Term Employment on Well-Being: Disentangling the Micro-Mechanisms and the Moderating Role of Social Cohesion

2020 ◽  
Vol 152 (1) ◽  
pp. 91-115
Author(s):  
Sonja Scheuring
Keyword(s):  
Social Cohesion ◽  
Well Being ◽  
Control Group ◽  
Subjective Well Being ◽  
Social Contacts ◽  
Country Level ◽  
Micro Level ◽  
Deprivation Model ◽  
The Impact

Abstract This paper examines the impact of fixed-term employment on well-being from a cross-national comparative perspective by testing (1) the effect heterogeneity across European countries, (2) to which extent Jahoda’s Latent Deprivation Model provides a sufficient micro-level explanation for the underlying mechanisms and (3) whether the macro-level factor of social cohesion weakens the micro-level impacts. We investigate the effects in both an upwards (permanent employment) and a downwards (unemployment) comparative control group design. Due to the mediating role of social contacts on the micro-level, we assume social cohesion on the country-level to moderate the main effects: A high degree of societal affiliation should substitute the function of social contacts in the work environment of individuals. Using microdata from the European Social Survey (ESS) 2012 for 23 countries and applying multilevel estimation procedures, we find that there is a remarkable variation in the effects across countries. Even though in each country fixed-term employees have a lower subjective well-being compared to permanent ones, the point estimates vary from .17 to 1.19 units. When comparing fixed-term employees to unemployed individuals, the coefficients even range from − .27 to 1.25 units. More specifically, a negative effect indicates that having a fixed-term contract is worse than unemployment in some countries. Moreover, pooled linear regression models reveal that Jahoda’s Latent Deprivation Model explains about three-quarters of the micro-level effect sizes for both directions. Eventually, social cohesion on the country-level diminishes the individual-level well-being differences between fixed-term employees and permanent individuals but not between fixed-term employees and the unemployed.

Mamillary Body Lesions in Monkeys Impair Object-in-Place Memory: Functional Unity of the Fornix-Mamillary System

1997 ◽  
Vol 9 (4) ◽  
pp. 512-521 ◽  
Author(s):  
Amanda Parker ◽  
David Gaffan
Keyword(s):  
Episodic Memory ◽  
Memory Task ◽  
Control Group ◽  
Thalamic Nuclei ◽  
Mamillary Body ◽  
Control Operation ◽  
Place Memory ◽  
Severe Impairment ◽  
Anterior Thalamic Nuclei

Six monkeys were trained preoperatively in an automated object-in-place memory task in which they learned 20 new scenes in each daily session. Three of the six monkeys then received stereotaxically guided bilateral mamillary body lesions, leaving the fornix intact, while the other three received a control operation. Postoperatively the control animals' rate of learning new scenes was unchanged, but the animals with mamillary body lesions showed a severe impairment, equal to that seen in previous experiments after fornix transection. All six animals were then given fornix transection, in addition to the existing mamillary or control operation. The control group now showed, after fornix transection, an impairment equal to that of the animals with mamillary body lesions alone. But the animals with mamillary body lesions did not show any additional impairment following fornix transection. We conclude that (1) the role of the mamillary bodies in a model of human episodic memory is as important as the role of the fornix, (2) the fornix and mamillary bodies form a single functional memory system, since the effect of lesions in both parts is no more severe than the effects of a lesion in one of the parts alone, and (3) the idea that the functional effects of fornix transection result from cholmergic deafferentation of the hippocampus receives no support from the present results; rather, they support the idea that in primates the fornix and mamillary bodies, together with connected structures, including the subiculum, mamillo-thalamic tract, anterior thalamic nuclei, and cingulate bundle, form a cortico-cortical association pathway for episodic memory.

Role of bradykinin B1 and B2 receptors in normal blood pressure regulation

2006 ◽  
Vol 291 (2) ◽  
pp. E268-E274 ◽  
Author(s):  
Arvi Duka ◽  
Irena Duka ◽  
Guohong Gao ◽  
Sherene Shenouda ◽  
Irene Gavras ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Receptor Gene ◽  
Normal Blood ◽  
Control Group ◽  
Normal Blood Pressure ◽  
Concurrent Administration ◽  
Vasoactive Factors ◽  
Hoe 140 ◽  
The Impact

With inhibition or absence of the bradykinin B2 receptor (B2R), B1R is upregulated and assumes some of the hemodynamic properties of B2R, indicating that both participate in the maintenance of normal vasoregulation or to development of hypertension. Herein we further evaluate the role of bradykinin in normal blood pressure (BP) regulation and its relationship with other vasoactive factors by selectively blocking its receptors. Six groups of Wistar rats were treated for 3 wk: one control group with vehicle alone, one with concurrent administration of B1R antagonist R-954 (70 μg·kg−1·day−1) and B2R antagonist HOE-140 (500 μg·kg−1·day−1), one with R-954 alone, one with HOE 140 alone, one with concurrent administration of both R-954 and HOE-140 plus the angiotensin antagonist losartan (5 mg·kg−1·day−1), and one with only losartan. BP was measured continuously by radiotelemetry. Only combined administration of B1R and B2R antagonists produced a significant BP increase from a baseline of 107–119 mmHg at end point, which could be partly prevented by losartan and was not associated with change in catecholamines, suggesting no involvement of the sympathoadrenal system. The impact of blockade of bradykinin on other vasoregulating systems was assessed by evaluating gene expression of different vasoactive factors. There was upregulation of the eNOS, AT1 receptor, PGE2 receptor, and tissue kallikrein genes in cardiac and renal tissues, more pronounced when both bradykinin receptors were blocked; significant downregulation of AT2 receptor gene in renal tissues only; and no consistent changes in B1R and B2R genes in either tissue. The results indicate that both B1R and B2R contribute to the maintenance of normal BP, but one can compensate for inhibition of the other, and the chronic inhibition of both leads to significant upregulation in the genes of related vasoactive systems.

The Impact of Different Teaching Strategies on Teaching Spelling to Kindergarten Children

2016 ◽  
Vol 7 (4) ◽  
pp. 730
Author(s):  
Ali Hashemi ◽  
Omid Ghalkhani
Keyword(s):  
Language Teaching ◽  
Kindergarten Students ◽  
Kindergarten Children ◽  
Control Group ◽  
Language Curriculum ◽  
The Public ◽  
Correct Spelling ◽  
The Impact ◽  
Arts Community

Many specialists in the field of foreign language teaching consider spelling as an important and perhaps necessary part in language teaching, and observe that spelling is a significant concern among both the language arts community and the public. The teaching of spelling is an issue that provokes strong feelings and attitudes in teachers, students, and parents as well, and those involved have strong opinions about the importance of correct spelling at school. A close look at the role of spelling in the general language curriculum, makes it known that learning to write and read in the whole language can benefit greatly from teaching spelling. Searching the Net under the keywords ‘spelling’ and ‘teaching spelling’ reveals many studies on spelling and the interest of the readers. In this study, we made use of two techniques to teach spelling, which included “the Personalized Instruction Technique”, or simply the PI technique, and “the Detection Technique” or the D technique. Meanwhile, a control group was included to make up for and take into account any possible background differences.82 kindergarten children, studying at three kindergartens in Tarom, Zanjan, took part in the study. They were randomly assigned to three groups: one control group and two experimental groups. The PI group consisted of 28 kindergarten students both boys and girls, and the Group comprised 27kindergarten students, both boys and girls. The control group, too, contained 27 kindergarten students, both boys and girls. The findings indicated that both the experimental groups that used the spelling techniques performed significantly better than the control group. Meanwhile, the PI group exceeded the DT group.

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