Effects of Raloxifeneon on Ovarian Tissue of Mature Female Rats

2014 ◽  
Vol 11 (2) ◽  
pp. 1013-1017
Author(s):  
Ebadi Zahra ◽  
Kargar Jahromi Hossein ◽  
Abedi Hassan Ali ◽  
Farzam Mohsen ◽  
Farzam Mohammad
Keyword(s):  
Ovarian Tissue ◽  
Mature Female ◽  
Female Rats

scholarly journals Are skeletally mature female rats a suitable model to study osteoporosis?

2012 ◽  
Vol 56 (4) ◽  
pp. 259-264 ◽  
Author(s):  
Claudia Cardoso Netto ◽  
Vivian Cristine Correia Vieira ◽  
Lizanka Paola Figueiredo Marinheiro ◽  
Sherry Agellon ◽  
Hope Weiler ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Type I Collagen ◽  
Biomechanical Properties ◽  
Mature Female ◽  
Female Rats ◽  
Suitable Model ◽  
Type I ◽  
Age Related ◽  
Female Wistar Rats ◽  
Old Rats

OBJECTIVE: To analyze if female Wistar rats at 56 weeks of age are a suitable model to study osteoporosis. MATERIALS AND METHODS: Female rats with 6 and 36 weeks of age (n = 8 per group) were kept over a 20-week period and fed a diet for mature rodents complete in terms of Ca, phosphorous, and vitamin D. Excised femurs were measured for bone mass using dual-energy x-ray absorptiometry, morphometry, and biomechanical properties. The following serum mar-kers of bone metabolism were analyzed: parathyroid hormone (PTH), osteocalcin (OC), osteoprotegerin (OPG), receptor activator of nuclear factor Κappa B ligand (RANKL), C-terminal peptides of type I collagen (CTX-I), total calcium, and alkaline phosphatase (ALP) activity. RESULTS: Rats at 56 weeks of age showed important bone metabolism differences when compared with the younger group, such as, highest diaphysis energy to failure, lowest levels of OC, CTX-I, and ALP, and elevated PTH, even with adequate dietary Ca. CONCLUSION: Rats at 26-week-old rats may be too young to study age-related bone loss, whereas the 56-week-old rats may be good models to represent the early stages of age-related changes in bone metabolism.

Effect of Estrogen on Bone Mineral Turnover in Mature Female Rats as Measured by Strontium-85

1970 ◽  
Vol 135 (3) ◽  
pp. 883-886 ◽  
Author(s):  
J. J. B. Anderson ◽  
J. W. Greenfield ◽  
J. R. Posada ◽  
W. C. Crackel
Keyword(s):  
Bone Mineral ◽  
Mature Female ◽  
Female Rats

Core temperature in the female rat: effect of pinealectomy or altered lighting

1976 ◽  
Vol 231 (2) ◽  
pp. 355-360 ◽  
Author(s):  
F Spencer ◽  
HW Shirer ◽  
JM Yochim
Keyword(s):  
Core Temperature ◽  
Continuous Light ◽  
Mature Female ◽  
Female Rats ◽  
Female Rat ◽  
Light Phase ◽  
Continuous Darkness ◽  
Temperature Rhythm ◽  
Two Component ◽  
Lighting Regimen

Radiotelemetry of core temperature in unrestrained, mature female rats revealed the existence of a 24-h rhythm that was bimodal. The principal peak occurred during the night under control conditions of 14 h light and 10 h darkness, and a less pronounced, secondary peak occurred 3-4 h after the onset of the light phase. Shifts in the phase of the photoperiod or alteration of the proportion of light per day revealed that the temperature rhythm was entrained by light, but that the two component peaks were governed by different aspects of the lighting regimen. Exposure of rats to continuous darkness, continuous light, or to a 20-h photoperiod revealed that the primary rhythm was endogenous, entrained by circadian photoperiods only, whereas the secondary rhythm was exogenous, requiring a circadian light/dark rhythm. A relationship between mean core temperature and ttion pressure, end-systolic L was constant, despite variations in filling and therefore independent of initial L and delta L; moreover, the L to which the ventricle shortened was determined by the course of the systolic force L-relation. Thus, irrespective of loading, delta L occurs within the confines of the contractile state-depdendent isovolumic force-L relation and where the latter is equivalent to the end-systolic force-length relation.

Stimulation of food intake and weight gain in mature female rats by bovine prolactin and bovine growth hormone

1993 ◽  
Vol 264 (6) ◽  
pp. E986-E992 ◽  
Author(s):  
J. C. Byatt ◽  
N. R. Staten ◽  
W. J. Salsgiver ◽  
J. G. Kostelc ◽  
R. J. Collier
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Mature Female ◽  
Female Rats ◽  
Bovine Growth Hormone ◽  
Female Rat ◽  
Moisture Percentage

Recombinant bovine prolactin (rbPRL) or bovine growth hormone (rbGH) was administered to mature female rats (10/treatment group) by daily subcutaneous injection for 10 days. Doses ranged from 7 to 5,000 micrograms/day (0.03-24 mg/kg body wt). Both rbPRL and rbGH increased body weight gain and food intake, but these parameters were increased at lower doses of rbPRL (7-63 micrograms/day) than rbGH (> 190 micrograms/day). Weight gain and food intake were maximally stimulated by 190 micrograms/day rbPRL, whereas maximal increased weight gain was obtained with the highest dose of rbGH (5,000 micrograms/day). Total carcass protein was increased by both hormones; however, protein as a percentage of body weight was unchanged. Similarly, neither rbPRL nor rbGH changed the percentage of carcass moisture. Percentage of body fat was increased by rbPRL but was decreased by rbGH. Weight of the gastrointestinal tract and kidneys was increased by both hormones, but increases were in proportion to body weight gain. These data confirm that ungulate prolactin is a hyperphagic agent in the female rat. In addition, they suggest that, while prolactin stimulates growth in mature female rats, this growth is probably not via a somatogenic mechanism.

scholarly journals Sphingosine 1-phosphate protects against radiation-induced ovarian injury in female rats—impact on mitochondrial-related genes

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Jiahui Zhao ◽  
Shuyun Zhang ◽  
Liesong Chen ◽  
Xiaolong Liu ◽  
Haihong Su ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Protective Effect ◽  
Mitochondrial Function ◽  
Target Genes ◽  
Ovarian Function ◽  
Ovarian Tissue ◽  
Differentially Expressed ◽  
Female Rats ◽  
Sphingosine 1 Phosphate ◽  
Radiation Induced

Abstract The toxic effects of ionizing radiation on the gonads have been widely recognized. Sphingosine 1-phosphate (S1P) has a protective effect on ovarian injury, and although it is known that mitochondria are involved in this process, the specific mechanism is not fully understood. The present study analysed the changes in the serum AMH and ovarian histology in Sprague-Dawley female rats exposed to X-ray radiation only or co-administered with S1P. The mRNA expression profile of ovarian tissue was further analysed via next-generation sequencing and bioinformatics approaches to screen out candidate mitochondria-related genes. Finally, differentially expressed target genes were verified by real-time PCR. The results showed that ionizing radiation could reduce the serum AMH level, destroy ovarian structure and decrease the number of follicles in rats, while S1P administration significantly attenuated the impairment of ovarian function. Gene ontology (GO) and KEGG pathway analysis revealed that a variety of genes related to mitochondrial function were differentially expressed, and the protective effect of S1P on mitochondria was more obvious in the acute phase 24 h after radiation. The differentially expressed mitochondrial function-related genes associated with the protective effect of S1P were UQCRH, MICU2 and GPX4, which were subsequently verified by RT-PCR. Therefore, ionizing radiation has a significant effect on ovarian function, and S1P has a protective effect on radiation-induced ovarian injury, in which mitochondria may play an important role. This study sheds new light on the mechanism of radiation-induced ovarian injury and helps develop a novel potential strategy to control it.

Recovery of Body Weight from Below “Set Point” in Mature Female Rats

1984 ◽  
Vol 114 (6) ◽  
pp. 1143-1150 ◽  
Author(s):  
Ruth B. S. Harris ◽  
Roy J. Martin
Keyword(s):  
Body Weight ◽  
Mature Female ◽  
Female Rats ◽  
Set Point

Strontium-calcium interrelationships in the mature rat

1960 ◽  
Vol 199 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Roy C. Thompson ◽  
Ray F. Palmer
Keyword(s):  
Calcium Intake ◽  
Calcium Level ◽  
Dietary Calcium ◽  
Mature Female ◽  
Female Rats ◽  
Total Calcium ◽  
Calcium Diet ◽  
Low Calcium ◽  
Extensive Exchange ◽  
Metabolic Behavior

The comparative metabolic behavior of strontium and calcium was studied in mature, female rats exposed both chronically and acutely to Sr90 and Ca45, while on diets of various total calcium contents. When orally administered, there is a discrimination against Sr90 relative to Ca45, apparent in the isotope levels in both blood and bone. This discrimination becomes smaller in magnitude as the level of calcium intake is increased. On all levels of calcium intake there is extensive exchange of calcium and strontium between bone and blood. On low-calcium diets the calcium moving from bone to blood is almost completely reutilized; as the level of dietary calcium is increased, this reutilization becomes less efficient and the rate of net removal of calcium from bone increases. In contrast, the rate of net removal of strontium from bone was relatively insensitive to changes in dietary calcium level, and on all diets was similar to the rate of net removal of calcium on the highest calcium diet.

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