Anti-trypanosomal activity of Carica papaya aqueous seed extracts in mice

2012 ◽  
Vol 9 (2) ◽  
pp. 617-622
Author(s):  
Nurul Jamiiah A. Samad ◽  
B.A.H. Zainal-Abidin
Keyword(s):  
Carica Papaya ◽  
Seed Extracts

Antibacterial and Antifungal activity of Carica papaya L seed extracts

2021 ◽  
Vol 14 (2) ◽  
pp. 1085-1090
Author(s):  
S. Sundar ◽  
K. Padmalatha ◽  
SK. Apsana ◽  
P. Himaja ◽  
V. Nandini ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Carica Papaya ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal ◽  
Seed Extracts

scholarly journals In-vitro and In-vivo Evaluation of Anti-trypanosomal Activity of Carica papaya Seed Extracts and Fractions in Albino Wister Rats

2020 ◽  
pp. 13-25
Author(s):  
H. Kinjir ◽  
M. A. Madusolumuo ◽  
S. Sarkiyayi
Keyword(s):  
Carica Papaya ◽  
Oral Toxicity ◽  
Infection Level ◽  
In Vivo Evaluation ◽  
Trypanocidal Activity ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Seed Extracts

Aims: This study presents baseline data on the In-vitro and In-vivo evaluation of anti-trypanosomal activity of Carica papaya seed extracts and fractions in Albino Wister rats. Study Design: Mention the design of the study here. Place and Duration of Study Sample: Department of Biochemistry, Modibbo Adama University of Technology, Yola, between June 2009 and July 2010. Methodology: 56 Wister rats of both sexes were randomly divided into 8 groups (I – VIII) of 7 rats each were used for this study. Four concentrations (100, 200, 400 and 800 mg/kg) of different extracts of seed carica papaya were screened for trypanocidal activity against Trypanosoma brucei In vitro and In vivo. The effect of the extracts was evaluated for trypanocidal activity in rats infected and not infected with the parasite. Administration of the extract and the drugs was orally daily for 5 consecutive days from day 7 of post infection. Level of parasitemia and body weight was taken daily for 21 days. Results: The extracts inhibited parasite motility and totally eliminated the organisms at the concentrations used In vitro. The extract also showed promising in vivo trypanocidal activity. The observed In vitro and In vivo trypanocidal activities may be due to the presence of bioactive compounds present in the extracts as seen in this study. The extract also improved the observed decreases in haematological parameters of the treated rats, which may be due to their ability to decrease parasite load. The LD50 was estimated to be ≥2,000 mg/Kg (v/v) for acute oral toxicity test (because all the rats survived at the end of the 14-day observation period). This is an indication of very low toxicity, implying that the extract could be administered with some degree of safety. A significant decreased (p<0.05) were observed in weight of rats at 100 mg/kg, 200 mg/kg 400 mg/kg 800 mg/kg negative control and prophylactic at four to eight days of infections, while significantly increased (p<0.05) were observed in weight of rats for berenil control and normal control. Conclusion: The decrease in weight of rats could be as a result of loss of appetite due to severe fever and also the trypanosome.

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

2019 ◽  
Vol 43 (12) ◽  
Author(s):  
Ali H. Amin ◽  
Faisal A. Bughdadi ◽  
Mabrouk A. Abo‐Zaid ◽  
Ahmed H. Ismail ◽  
Sherif A. El‐Agamy ◽  
...  
Keyword(s):  
Carica Papaya ◽  
Immunomodulatory Effect ◽  
Natural Treatment ◽  
Papaya Pulp ◽  
Seed Extracts

scholarly journals Proximate Composition and Phytochemical Constituents of Matured Carica papaya Seed Extracts

2021 ◽  
pp. 28-33
Author(s):  
M. A. Kanadi ◽  
R. Yila ◽  
M. P. Ibrahim ◽  
A. I. Yaradua ◽  
A. Nasir
Keyword(s):  
Ethyl Acetate ◽  
Proximate Composition ◽  
Carica Papaya ◽  
Chloroform Extract ◽  
Phytochemical Analysis ◽  
Crude Fibre ◽  
Phytochemical Constituents ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Seed Extracts

Aim: To investigate the proximate composition and phytochemical constituents of matured Carica papaya seed. Study Design: Proximate composition was determined on Carica papaya seed powder while extracts for phytochemical analysis were obtained, in turn using five different solvents of varying polarity, namely n-hexane, chloroform, ethyl acetate, methanol and water. Place and Duration of Study: Department of Biochemistry, Faculty of Basic Medical sciences, Bayero University Kano, Nigeria. The study was carried out between March- April, 2019. Results: The proximate composition of matured Carica papaya seed showed it contained crude fat (27.72%), carbohydrate (23.34%), crude fibre (21.25%), ash (10.25%), crude protein (9.65%) and moisture (7.34%). Qualitative phytochemical screening of Carica papaya seed extracts detected major phytochemicals except anthraquinones and quantitative analyses of these phytochemicals in all the five extracts showed that flavonoids was the most abundant phytochemical with 38.68%, 35.85%, 36.76%, 34.04% and 23.50% for methanol, aqueous, chloroform, n-hexane and ethyl acetate fractions respectively while tannins was the least abundant phytochemical with 0.03% for methanol extract, 0.04% for n-hexane extract, 0.09% for aqueous and ethyl acetate extracts, and 0.14% for the chloroform extract. Conclusion: Seeds of matured Carica papaya contain major nutrients that may be useful in nutrition. The presence of phytochemicals such as flavonoids, alkaloids and saponins in considerable quantities explained the medicinal activity of the plant material as encountered in its therapeutic uses.

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