scholarly journals Letter to the Editor: Testosterone priming increased growth hormone peak levels in the stimulation test and suppressed gonadotropin secretion in three Japanese adolescent boys

2020 ◽  
Vol 29 (4) ◽  
pp. 201-201
Author(s):  
Kentaro Sawano ◽  
Keisuke Nagasaki
Keyword(s):  
Growth Hormone ◽  
Stimulation Test ◽  
Adolescent Boys ◽  
Gonadotropin Secretion ◽  
Growth Hormone Peak ◽  
Letter To The Editor

scholarly journals 30 ACUTE AND CHRONIC EFFECTS OF CLONIDINE ON GROWTH HORMONE AND GONADOTROPIN SECRETION IN ADOLESCENT BOYS

1985 ◽  
Vol 19 (6) ◽  
pp. 608-608
Author(s):  
Sleman A Khoury ◽  
Sue E Sauder ◽  
Paula M Hale ◽  
Nancy J Hopwood ◽  
Inese Z Beitins ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Adolescent Boys ◽  
Gonadotropin Secretion ◽  
Chronic Effects ◽  
Acute And Chronic Effects

scholarly journals Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion

2021 ◽  
pp. 1-24
Author(s):  
Jan M. Wit ◽  
Sjoerd D. Joustra ◽  
Monique Losekoot ◽  
Hermine A. van Duyvenvoorde ◽  
Christiaan de Bruin
Keyword(s):  
Growth Hormone ◽  
Differential Diagnosis ◽  
Growth Hormone Secretion ◽  
Normal Growth ◽  
Stimulation Test ◽  
Healthy Children ◽  
Genetic Causes ◽  
Gh Secretion ◽  
Igf I

The current differential diagnosis for a short child with low insulin-like growth factor I (IGF-I) and a normal growth hormone (GH) peak in a GH stimulation test (GHST), after exclusion of acquired causes, includes the following disorders: (1) a decreased spontaneous GH secretion in contrast to a normal stimulated GH peak (“GH neurosecretory dysfunction,” GHND) and (2) genetic conditions with a normal GH sensitivity (e.g., pathogenic variants of <i>GH1</i> or <i>GHSR</i>) and (3) GH insensitivity (GHI). We present a critical appraisal of the concept of GHND and the role of 12- or 24-h GH profiles in the selection of children for GH treatment. The mean 24-h GH concentration in healthy children overlaps with that in those with GH deficiency, indicating that the previously proposed cutoff limit (3.0–3.2 μg/L) is too high. The main advantage of performing a GH profile is that it prevents about 20% of false-positive test results of the GHST, while it also detects a low spontaneous GH secretion in children who would be considered GH sufficient based on a stimulation test. However, due to a considerable burden for patients and the health budget, GH profiles are only used in few centres. Regarding genetic causes, there is good evidence of the existence of Kowarski syndrome (due to <i>GH1</i> variants) but less on the role of <i>GHSR</i> variants. Several genetic causes of (partial) GHI are known (<i>GHR</i>, <i>STAT5B</i>, <i>STAT3</i>, <i>IGF1</i>, <i>IGFALS</i> defects, and Noonan and 3M syndromes), some responding positively to GH therapy. In the final section, we speculate on hypothetical causes.

scholarly journals The Role of Growth Hormone in the Control of Gonadotropin Secretion in Adult Male Rats*

Endocrinology ◽  
1998 ◽  
Vol 139 (3) ◽  
pp. 1067-1074 ◽  
Author(s):  
Varadaraj Chandrashekar ◽  
Andrzej Bartke
Keyword(s):  
Growth Hormone ◽  
Adult Male ◽  
Male Rats ◽  
Gonadotropin Secretion
Sign in / Sign up

Export Citation Format

Share Document