Short stature and failure of pubertal development in thalassaemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion

1997 ◽  
Vol 156 (10) ◽  
pp. 777-783 ◽  
Author(s):  
C. Roth ◽  
A. Pekrun ◽  
M. Bartz ◽  
H. Jarry ◽  
S. Eber ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Pubertal Development ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Thalassaemia Major ◽  
Gonadotropin Secretion ◽  
Pituitary Gonadotropin

Pituitary volume in children with growth hormone deficiency, idiopathic short stature and controls

2016 ◽  
Vol 29 (10) ◽  
Author(s):  
Marion Kessler ◽  
Michael Tenner ◽  
Michael Frey ◽  
Richard Noto
Keyword(s):  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Short Stature ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Magnetic Resonance Images ◽  
Idiopathic Short Stature ◽  
Hormone Deficiency ◽  
Significant Difference

AbstractBackground:The objective of the study was to describe the pituitary volume (PV) in pediatric patients with isolated growth hormone deficiency (IGHD), idiopathic short stature (ISS) and normal controls.Methods:Sixty-nine patients (57 male, 12 female), with a mean age of 11.9 (±2.0), were determined to have IGHD. ISS was identified in 29 patients (20 male, 9 female), with a mean age of 12.7 (±3.7). Sixty-six controls (28 female, 38 male), mean age 9.8 (±4.7) were also included. Three-dimensional (3D) magnetic resonance images with contrast were obtained to accurately measure PV.Results:There was a significant difference in the mean PV among the three groups. The IGHD patients had a mean PV 230.8 (±89.6), for ISS patients it was 286.8 (±108.2) and for controls it was 343.7 (±145.9) (p<0.001). There was a normal increase in PV with age in the ISS patients and controls, but a minimal increase in the IGHD patients.Conclusions:Those patients with isolated GHD have the greatest reduction in PV compared to controls and the patients with ISS fall in between. We speculate that a possible cause for the slowed growth in some ISS patients might be related to diminished chronic secretion of growth hormone over time, albeit having adequate pituitary reserves to respond acutely to GH stimulation. Thus, what was called neurosecretory GHD in the past, might, in some patients, be relative pituitary hypoplasia and resultant diminished growth hormone secretion. Thus, PV determinations by magnetic resonance imaging (MRI) could assist in the diagnostic evaluation of the slowly growing child.

Standard and low-dose IGF-I generation tests and spontaneous growth hormone secretion in children with idiopathic short stature

2004 ◽  
Vol 60 (2) ◽  
pp. 163-168 ◽  
Author(s):  
J. C. Blair ◽  
C. Camacho-Hübner ◽  
F. Miraki Moud ◽  
S. Rosberg ◽  
C. Burren ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Low Dose ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Idiopathic Short Stature ◽  
Spontaneous Growth ◽  
Igf I

Growth hormone secretion in patients with constitutional delay of growth and pubertal development

1986 ◽  
Vol 109 (5) ◽  
pp. 781-783 ◽  
Author(s):  
Roberto Lanes ◽  
Lottys Bohorquez ◽  
Vianey Leal ◽  
Guadalupe Hernández ◽  
Marietta Borges ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pubertal Development ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Constitutional Delay
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