scholarly journals Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey

2017 ◽  
Vol 26 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Masanori Adachi ◽  
Yuji Oto ◽  
Koji Muroya ◽  
Junko Hanakawa ◽  
Yumi Asakura ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Hematopoietic Stem ◽  
Partial Lipodystrophy

scholarly journals Hand hygiene: knowledge and skill of caregivers in the hematopoietic stem cell transplantation

2019 ◽  
Vol 72 (6) ◽  
pp. 1653-1662
Author(s):  
Daiane Rubinato Fernandes ◽  
Fernanda Titareli Merizio Martins Braga ◽  
Renata Cristina de Campos Pereira Silveira ◽  
Livia Maria Garbin
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Hand Hygiene ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Cross Sectional Study ◽  
Alcoholic Solution ◽  
Cross Sectional ◽  
Hematopoietic Stem

ABSTRACT Objective: to identify the knowledge and ability of caregivers on hand hygiene in hematopoietic stem cell transplantation. Method: a prospective cross-sectional study. A questionnaire was used to identify the knowledge and it was observed the hygiene technique performance. Data were collected in two units (autologous and allogeneic transplant). Results: the 37 participants recognized the importance of hand hygiene and 95.5% related to removal of dirt or infection prevention. 91.9% stated that it was important to clean their hands with soap and water when entering and leaving the room, and 64.9% understood that it was necessary to apply alcoholic solution after washing. On average, the caregivers scored 6.16 steps, when demonstrating the washing technique and 3.91 steps in the friction with alcoholic solution. Conclusion: although they recognize the importance of the procedure, there are deficits related to the moment and the correct way of doing it, evidencing the need for strategies aimed at improving this process.

Acquired partial lipodystrophy with metabolic disease in children following hematopoietic stem cell transplantation: a report of two cases and a review of the literature

2019 ◽  
Vol 32 (5) ◽  
pp. 537-541 ◽  
Author(s):  
Mayumi Hosokawa ◽  
Hironori Shibata ◽  
Takahiro Hosokawa ◽  
Junichiro Irie ◽  
Hiroshi Ito ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Glucose Tolerance ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Fat Distribution ◽  
Hematopoietic Stem ◽  
Partial Lipodystrophy

Abstract Hematopoietic stem cell transplantation (HSCT) has been newly identified as an etiology underlying acquired lipodystrophy (ALD). We report about two children with leukemia who underwent HSCT and later manifested aberrant fat distributions consistent with acquired partial lipodystrophy (APL). Both patients manifested graft-versus-host disease (GVHD), suggesting that GVHD may trigger lipodystrophy. The patients exhibited diabetic blood glucose patterns in the oral glucose tolerance test (OGTT) with high homeostasis model assessment ratios (HOMA-Rs), hypertriglyceridemia, fatty liver, and decreased serum leptin and adiponectin levels. Both patients were diagnosed with APL with metabolic disease. A review of the data of patients with ALD after HSCT revealed common clinical features, including aberrant fat distribution, impaired glucose tolerance (IGT) or diabetes and dyslipidemia. Based on previous reports and our two cases, we speculate that GVHD in the adipose tissue supports the development of ALD after HSCT. In conclusion, children may develop APL after HSCT. Therefore, evaluations of fat distribution and metabolic disease may be important during the long-term follow-up of these patients.

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