scholarly journals Abnormal Adipose Tissue Distribution with Unfavorable Metabolic Profile in Five Children Following Hematopoietic Stem Cell Transplantation: A New Etiology for Acquired Partial Lipodystrophy

2013 ◽  
Vol 22 (4) ◽  
pp. 53-64 ◽  
Author(s):  
Masanori Adachi ◽  
Yumi Asakura ◽  
Koji Muroya ◽  
Hiroaki Goto ◽  
Hisato Kigasawa
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Tissue Distribution ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Metabolic Profile ◽  
Hematopoietic Stem ◽  
Partial Lipodystrophy

Acquired partial lipodystrophy with metabolic disease in children following hematopoietic stem cell transplantation: a report of two cases and a review of the literature

2019 ◽  
Vol 32 (5) ◽  
pp. 537-541 ◽  
Author(s):  
Mayumi Hosokawa ◽  
Hironori Shibata ◽  
Takahiro Hosokawa ◽  
Junichiro Irie ◽  
Hiroshi Ito ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Glucose Tolerance ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Fat Distribution ◽  
Hematopoietic Stem ◽  
Partial Lipodystrophy

Abstract Hematopoietic stem cell transplantation (HSCT) has been newly identified as an etiology underlying acquired lipodystrophy (ALD). We report about two children with leukemia who underwent HSCT and later manifested aberrant fat distributions consistent with acquired partial lipodystrophy (APL). Both patients manifested graft-versus-host disease (GVHD), suggesting that GVHD may trigger lipodystrophy. The patients exhibited diabetic blood glucose patterns in the oral glucose tolerance test (OGTT) with high homeostasis model assessment ratios (HOMA-Rs), hypertriglyceridemia, fatty liver, and decreased serum leptin and adiponectin levels. Both patients were diagnosed with APL with metabolic disease. A review of the data of patients with ALD after HSCT revealed common clinical features, including aberrant fat distribution, impaired glucose tolerance (IGT) or diabetes and dyslipidemia. Based on previous reports and our two cases, we speculate that GVHD in the adipose tissue supports the development of ALD after HSCT. In conclusion, children may develop APL after HSCT. Therefore, evaluations of fat distribution and metabolic disease may be important during the long-term follow-up of these patients.

Caregiver perspectives on psychosocial care in pediatric hematopoietic stem cell transplantation (HCT).

2020 ◽  
Vol 8 (1) ◽  
pp. 67-78 ◽  
Author(s):  
Anne E. Kazak ◽  
Avi Madan Swain ◽  
Ahna L. H. Pai ◽  
Kimberly Canter ◽  
Olivia Carlson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Psychosocial Care ◽  
Hematopoietic Stem
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