scholarly journals New Synthesis of Heterobifunctional Poly(ethylene glycol) Possessing a Pyridyl Disulfide at One End and a Carboxylic Acid at the Other End

2005 ◽  
Vol 37 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Takehiko Ishii ◽  
Masayoshi Yamada ◽  
Takumi Hirase ◽  
Yukio Nagasaki
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
The Other ◽  
Poly Ethylene Glycol ◽  
New Synthesis ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol) Supported Metal Nitrates as Well-Organized Reagents for Hunsdiecker Conversion of α,β-Unsaturated Acids to β-Nitrostyrenes under Solvent and Acid-Free Conditions

2019 ◽  
Vol 31 (8) ◽  
pp. 1798-1800
Author(s):  
K. Ramesh ◽  
S. Shylaja ◽  
S. Ramgopal ◽  
A. Sambashiva Rao ◽  
K.C. Rajanna
Keyword(s):  
Ethylene Glycol ◽  
Solvent Free ◽  
The Other ◽  
Ferric Nitrate ◽  
Poly Ethylene Glycol ◽  
Peg 400 ◽  
Metal Nitrates ◽  
Solvent Free Conditions ◽  
Poly Ethylene ◽  
Supported Metal

Poly(ethylene glycol) (PEG) supported metal nitrates such as ferric nitrate and manganese nitrate were accomplished as well-organized reagents for Hunsdiecker conversion of α,β-unsaturated acids to β-nitrostyrenes under acid-free and solvent free conditions using grind-stone technique. However, in the case of unsaturated aliphatic acids, nitro alkene derivatives were obtained as products. PEG-400 was found the best among the other PEGs (PEG-200,300, 400, 600, 3000 and 6000) used in this protocol.

Grafting modification of epoxidized natural rubber with poly(ethylene glycol) monomethylether carboxylic acid and ionic conductivity of graft polymer composite electrolytes

RSC Advances ◽  
2016 ◽  
Vol 6 (108) ◽  
pp. 107021-107028 ◽  
Author(s):  
Ran Wang ◽  
Hua Mei ◽  
Wentan Ren ◽  
Yong Zhang
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Natural Rubber ◽  
Epoxidized Natural Rubber ◽  
Graft Polymer ◽  
Composite Electrolytes ◽  
Poly Ethylene Glycol ◽  
Grafting Reaction ◽  
Grafting Modification ◽  
Poly Ethylene

A novel polymer was synthesized via a grafting reaction of epoxidized natural rubber (ENR) with poly(ethylene glycol) monomethylether carboxylic acid (mPEG-COOH), which can improve the conductivity as a matrix of CPE.

scholarly journals Toxicity Assessment of a Single Dose of Poly(ethylene glycol) Diglycidyl Ether (PEGDE) Administered Subcutaneously in Mice

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 354
Author(s):  
Do-Hyun Kim ◽  
Jong-Hyeon Han ◽  
Hyuk-Cheol Kwon ◽  
Su-Jin Lim ◽  
Seo-Gu Han ◽  
...  
Keyword(s):  
Body Weight ◽  
Ethylene Glycol ◽  
Feed Intake ◽  
Diglycidyl Ether ◽  
Organ Weight ◽  
The Body ◽  
The Other ◽  
Poly Ethylene Glycol ◽  
Weight Variation ◽  
Poly Ethylene

Poly(ethylene glycol) diglycidyl ether (PEGDE) is widely used to cross-link polymers, particularly in the pharmaceutical and biomaterial sectors. However, the subcutaneous toxicity of PEGDE has not yet been assessed. PEGDE samples (500–40,000 μg/mouse) were subcutaneously injected into the paraspinal dorsum of BALB/c male mice. Cage-side observations were carried out with measurement of organ weight, body weight variation, and feed intake, as well as histopathological characterization on day 28 post-exposure. Mice that received 40,000 μg of PEGDE showed severe toxic response and had to be euthanized. Subcutaneous injection of PEGDE did not alter feed intake and organ weight; however, the body weight variation of mice injected with 20,000 μg of PEGDE was significantly lower than that of the other groups. Exposure to 10,000 and 20,000 μg of PEGDE induced epidermal ulcer formation and hair loss. The histology of skin tissue in mice administered with 20,000 μg of PEGDE showed re-epithelialized or unhealed wounds. However, the liver, spleen, and kidneys were histologically normal. Collectively, PEGDE, particularly above 10,000 μg/mouse, caused subcutaneous toxicity with ulceration, but no toxicity in the other organs. These results may indicate the optimal concentration of subcutaneously injected PEGDE.

scholarly journals Solid-state mechanochemical ω-functionalization of poly(ethylene glycol)

2017 ◽  
Vol 13 ◽  
pp. 1963-1968 ◽  
Author(s):  
Michael Y Malca ◽  
Pierre-Olivier Ferko ◽  
Tomislav Friščić ◽  
Audrey Moores
Keyword(s):  
Solid State ◽  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Small Molecule ◽  
Poly Ethylene Glycol ◽  
Chemical Manufacturing ◽  
Pharmacokinetic Profiles ◽  
Wide Range ◽  
Poly Ethylene ◽  
Peg Functionalization

Poly(ethylene glycol) (PEG) is a linear polymer with a wide range of applications in chemical manufacturing, drug development and nanotechnology. PEG derivatives are being increasingly used to covalently modify small molecule and peptide drugs, as well as bioactive nanomaterials in order to improve solubility in biological serum, reduce immunogenicity, and enhance pharmacokinetic profiles. Herein we present the development of mechanochemical procedures for PEG functionalization without the need for bulk solvents, offering a cleaner and more sustainable alternative to existing solution-based PEG procedures. The herein presented mechanochemical procedures enable rapid and solvent-free derivatization of PEG with tosyl, bromide, thiol, carboxylic acid or amine functionalities in good to quantitative yields and with no polymer chain oligomerization, proving the versatility of the method.

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