scholarly journals Controlled Release Behavior of Prodrugs Based on the Biodegradable Poly(L-glutamic acid) Microspheres

1999 ◽  
Vol 31 (10) ◽  
pp. 813-816 ◽  
Author(s):  
Kong Soo Kim ◽  
Tae Kyoung Kim ◽  
Neil B Graham
Keyword(s):  
Controlled Release ◽  
Glutamic Acid ◽  
Release Behavior ◽  
Biodegradable Poly

scholarly journals Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin

2017 ◽  
Vol 76 ◽  
pp. 743-751 ◽  
Author(s):  
Laura Jaimes-Aguirre ◽  
Enrique Morales-Avila ◽  
Blanca E. Ocampo-García ◽  
Luis Alberto Medina ◽  
Gustavo López-Téllez ◽  
...  
Keyword(s):  
Folic Acid ◽  
Glutamic Acid ◽  
Targeted Delivery ◽  
Biodegradable Poly

Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique

2014 ◽  
Vol 1060 ◽  
pp. 45-49
Author(s):  
Kamonrak Cheewatanakornkool ◽  
Pornsak Sriamornsak
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Diclofenac Sodium ◽  
Gastric Fluid ◽  
Layer By Layer ◽  
Release Behavior ◽  
Freeze Dried ◽  
Layer Technique ◽  
Calcium Pectinate ◽  
Layer By Layer Technique

The main objective of this study was to fabricate biopolymer-based microbeads, providing enteric properties and controlled release of diclofenac sodium, using layer-by-layer technique. The calcium pectinate microbeads have been designed and coated with chitosan and pectin multilayers. Drug release was performed in simulate gastric fluid (pH 1.2) for 2 hours, followed by pH 6.8 buffer for 8 hours. The effects of chitosan concentration, number of layer and drying technique on drug release were investigated. The results showed that the calcium pectinate microbeads could be simply prepared by ionotropic gelation and then coated with chitosan and pectin solutions using layer-by-layer procedure. The diameter of the microbeads ranged from 800 to 1000 μm for air-dried samples and from 1 to 2 mm for freeze-dried samples. The freeze-dried microbeads had a rough surface and many pores inside, as observed by SEM. The microbeads coated with 4% chitosan/4% pectin revealed a slower drug release than those coated with 1% chitosan/4% pectin and demonstrated a controlled release pattern. Moreover, different drying techniques and numbers of layer also influenced drug release behavior of the prepared microbeads.

Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release

2012 ◽  
Vol 89 (4) ◽  
pp. 1207-1214 ◽  
Author(s):  
Yunyan Bai ◽  
Zhe Zhang ◽  
Aiping Zhang ◽  
Li Chen ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Controlled Release ◽  
Glutamic Acid ◽  
Hydroxypropyl Cellulose ◽  
Oral Insulin ◽  
Ph Responsive

Tuning Controlled Release Behavior of Starch Granules Using Nanofibrillated Cellulose Derived from Waste Sugarcane Bagasse

2018 ◽  
Vol 6 (7) ◽  
pp. 9208-9217 ◽  
Author(s):  
Mayur D. Patil ◽  
Vishal D. Patil ◽  
Aditya A. Sapre ◽  
Tushar S. Ambone ◽  
Arun Torris A. T. ◽  
...  
Keyword(s):  
Controlled Release ◽  
Sugarcane Bagasse ◽  
Nanofibrillated Cellulose ◽  
Starch Granules ◽  
Release Behavior

Eccentric magnetic microcapsules for orientation-specific and dual stimuli-responsive drug release

2015 ◽  
Vol 3 (22) ◽  
pp. 4530-4538 ◽  
Author(s):  
Jingxian Huang ◽  
Chongdai Luo ◽  
Wanbo Li ◽  
Yan Li ◽  
Yu Shrike Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Release Behavior ◽  
Stimuli Responsive

Uniform eccentric magnetic microcapsules show controlled-release behavior for orientation-specific and dual stimuli-responsive drug delivery under ultrasound and laser regulation.

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