scholarly journals Immunohistochemical Characterization of Parafollicular Cell Adenoma, Medullary Carcinoma and Follicular Adenocarcinoma in Thyroid of Horses

2005 ◽  
Vol 16 (1) ◽  
pp. 11-17
Author(s):  
Toshifumi OYAMADA ◽  
Hideaki UEKI ◽  
Hiroyuki KOWATARI ◽  
Park CHUN-HO ◽  
Yoshinari KATAYAMA ◽  
...  
Keyword(s):  
Medullary Carcinoma ◽  
Cell Adenoma ◽  
Parafollicular Cell

Identification and Characterization of Calcitonin Forms in Plasma and Urine of Normal Subjects and Medullary Carcinoma Patients*

1983 ◽  
Vol 57 (4) ◽  
pp. 749-754 ◽  
Author(s):  
PAUL H. TOBLER ◽  
FRITZ A. TSCHOPP ◽  
MAXIMILIAN A. DAMBACHER ◽  
WALTER BORN ◽  
JAN A. FISCHER
Keyword(s):  
Medullary Carcinoma ◽  
Normal Subjects ◽  
Identification And Characterization

Immunocytochemical characterization of two thyroid medullary carcinoma cell linesin vitro

1995 ◽  
Vol 27 (11) ◽  
pp. 859-868
Author(s):  
Maciej Zabel ◽  
Jolanta Seidel ◽  
Aldona Kaczmarek ◽  
Joanna Surdyk-Zasada ◽  
Jan Grzeszkowiak ◽  
...  
Keyword(s):  
Carcinoma Cell ◽  
Medullary Carcinoma ◽  
Thyroid Medullary Carcinoma

Comprehensive genomic profiling of 443 cases of renal cell carcinoma to reveal frequent clinically relevant genomic alterations.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 433-433 ◽  
Author(s):  
Sumanta Kumar Pal ◽  
Siraj M. Ali ◽  
Zachary Chalmers ◽  
Jose A. Karam ◽  
Julia Andrea Elvin ◽  
...  
Keyword(s):  
Targeted Therapies ◽  
Collecting Duct ◽  
Medullary Carcinoma ◽  
Patient Specific ◽  
Genomic Profiling ◽  
Genomic Alterations ◽  
Medical Need ◽  
Comprehensive Genomic Profiling ◽  
Metastatic Sites

433 Background: Despite the availability of targeted therapy, effective management of advanced RCC is an unmet medical need as treatment is not personalized and is not guided by patient-specific genomic alterations (GAs). To assess the spectrum of clinically relevant GAs (CRGAs) in advanced RCC, comprehensive genomic profiling (CGP) of clinical RCC samples was performed with the goal of informing use of existing and novel targeted therapies. Methods: DNA was extracted from 40 microns of FFPE sections from 443 consecutive patients with relapsed/metastatic RCC. CGP was performed on hybridization-captured, adaptor ligation based libraries to a mean coverage depth of 646X for 3,230 exons of 182 cancer-related genes plus 37 introns from 14 genes frequently rearranged in cancer. The CGP assay included base substitutions (SUB), INDELs, copy number alterations (CNA) and fusions/rearrangements. CRGA were defined as GA linked to drugs on the market or under evaluation in mechanism driven clinical trials. Results: There were 73% male and 27% female patients with a mean age of 56 years, and the majority of cases were advanced stage with 198/443 specimens (44.6%) from metastatic sites. 400/443 patients (89%) had at least 1 GA on CGP with a mean 3.1 GA/case. 396/400 RCC harboring GA had at least 1 CRGA involving 111 individual genes with a mean of 1.32 CRGA/UC. The most common novel CRGA in order of frequency were: CDKN2A (21%), BAP1 (12%), ATM (11%), PTEN(8.5%), TSC1(8.3%), mTOR (7%), MET (6.5%), AR (5.3%), DNMT3A (5%) and TSC2 (5%). Moreover, VHL harbored a diversity of GA’s in in 49% of cases. Collecting duct carcinomas harbored an enrichment of NF2 truncating alterations (>40%), distinct from renal medullary carcinoma which did not harbor such GA. Multiple clinical antitumor responses to targeted therapies will be presented. Conclusions: Using a CGP assay capable of detecting all classes of GA simultaneously, a high frequency of CRGA was identified in a large series of patients with advanced RCC. The diversity of CRGA suggests opportunities for the rational application of existing and investigational targeted therapies, and for possible deeper characterization of histological types of RCC.

scholarly journals Genomic Characterization of Renal Medullary Carcinoma and Treatment Outcomes

2017 ◽  
Vol 15 (6) ◽  
pp. e987-e994 ◽  
Author(s):  
Maria I. Carlo ◽  
Joshua Chaim ◽  
Sujata Patil ◽  
Yelena Kemel ◽  
Alison M. Schram ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Medullary Carcinoma ◽  
Renal Medullary Carcinoma ◽  
Genomic Characterization

scholarly journals Morphological Spectrum of Lesions Seen in Thyroidectomy Specimens At A Tertiary Care Institute

Esculapio ◽  
2020 ◽  
Vol 16 (03, july 2020-Septmber 2020) ◽  
Author(s):  
Iram Nadeem ◽  
Samra Sameen ◽  
Sahar Iqbal ◽  
Tazeen Anis
Keyword(s):  
Papillary Carcinoma ◽  
Tertiary Care ◽  
Follicular Adenoma ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Cell Adenoma ◽  
Care Institute ◽  
Hyalinizing Trabecular Tumor ◽  
Neoplastic Lesions

Objective: To determine the morphological spectrum of thyroid lesions encountered in thyroidectomy specimens at a tertiary care institute. Methods: It was a retrospective study conducted in Pathology Department, Allama Iqbal Medical College, Lahore. A retrospective manual collection of data was done from record registers, for the years 2012 & 2013. Results: A total of 307 cases were retrieved with age range of 16-70 years. Amongst them, 47 were males and 260 were females. Non neoplastic conditions outnumbered the neoplastic lesions as 229(75%) cases were of colloid goiter. Hashimoto thyroiditis was present in 12(3.9%) specimens and associated hyperplastic changes were seen in 15(4.9%) cases. There were 19(6.2%) cases of papillary carcinoma, 3(0.9%) cases of follicular carcinoma, 3(0.9%) cases of medullary carcinoma, 1(0.3 %) case of insular carcinoma and 2(0.6%) anaplastic carcinoma. Papillary microcarcinoma was seen in 4(1.3 %) cases and medullary microcarcinoma in 1(0.3%) case. Follicular adenoma comprised 29(9.4%) cases and Hurthle cell adenoma 3(0.9%) cases. Study data also showed 1(0.3%) rare case of hyalinizing trabecular tumor. Conclusion: Non neoplastic thyroid diseases are more common as compared to neoplastic lesions. Papillary carcinoma is most common thyroid malignancy encountered in our setting. Key Words: Thyroidectomy, Colloid goiter, papillary carcinoma

Immunocytochemical characterization of two thyroid medullary carcinoma cell lines in vitro

1995 ◽  
Vol 27 (11) ◽  
pp. 859-868
Author(s):  
Maciej Zabel ◽  
Jolanta Seidel ◽  
Aldona Kaczmarek ◽  
Joanna Surdyk-Zasada ◽  
Jan Grzeszkowiak ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Medullary Carcinoma ◽  
Thyroid Medullary Carcinoma ◽  
Carcinoma Cell Lines

Molecular characterization of renal medullary carcinoma (RMC).

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 4586-4586
Author(s):  
Jianjun Gao ◽  
Hui Yao ◽  
Xiaoping Su ◽  
Priya Rao ◽  
Padmanee Sharma ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Medullary Carcinoma ◽  
Renal Medullary Carcinoma

The Thyroid Hürthle (Oncocytic) Cell and Its Associated Pathologic Conditions: A Surgical Pathology and Cytopathology Review

2008 ◽  
Vol 132 (8) ◽  
pp. 1241-1250 ◽  
Author(s):  
Kathleen T. Montone ◽  
Zubair W. Baloch ◽  
Virginia A. LiVolsi
Keyword(s):  
Differential Diagnosis ◽  
Medullary Carcinoma ◽  
Thyroid Neoplasms ◽  
Cell Adenoma ◽  
Hürthle Cell ◽  
Oncocytic Variant ◽  
Hurthle Cells ◽  
Hürthle Cells ◽  
Thyroid Lesions

Abstract Context.—Hürthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions. The differential diagnosis of Hürthle cell lesions is quite broad. Objective.—To review the pathologic conditions associated with Hürthle cells in the thyroid and to discuss pathology of thyroid lesions associated with oncocytic cytology. Data Sources.—A variety of thyroid nonneoplastic (autoimmune thyroiditis, multinodular goiter) and neoplastic conditions (Hürthle cell adenoma, Hürthle cell carcinoma) are associated with Hürthle cell cytology. In addition, there are several thyroid neoplasms that should be considered when one observes a Hürthle cell neoplasm in the thyroid (oncocytic variant of medullary carcinoma, several variants of papillary thyroid carcinoma). Conclusions.—Oncocytic cytology is seen in a variety of thyroid conditions that are associated with a broad differential diagnosis and care must be used for accurate diagnosis. Newer molecular-based techniques may be useful for further classification of thyroid neoplasms with oncocytic pathology.

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