scholarly journals Protective Effect of Stachybotrys microspora Triprenyl Phenol-7on the Deposition of IgA to the Glomerular Mesangium in Nivalenol-induced IgA Nephropathy Using BALB/c Mice

2012 ◽  
Vol 25 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Sayaka Kemmochi ◽  
Hitomi Hayashi ◽  
Eriko Taniai ◽  
Keiji Hasumi ◽  
Yoshiko Sugita-Konishi ◽  
...  
Keyword(s):  
Protective Effect ◽  
Iga Nephropathy ◽  
Glomerular Mesangium ◽  
Stachybotrys Microspora

Sensorineural deafness associated with IgA nephropathy

1989 ◽  
Vol 103 (4) ◽  
pp. 412-412 ◽  
Author(s):  
N. L. Ataya
Keyword(s):  
Renal Biopsy ◽  
Iga Nephropathy ◽  
Immune Complex ◽  
Sensorineural Deafness ◽  
Immune Complex Glomerulonephritis ◽  
Glomerular Mesangium ◽  
Subsequent Onset

AbstractIgA nephropathy is an immune complex glomerulonephritis in which examination of the renal biopsy by immu-nofluorescence reveals IgA as the predominant antibody deposited in the glomerular mesangium (Clarkson et al., 1984). It was first described by Berger in 1969. The disease is more common in males and occurs generally during the second or third decades of life (Emancipator et al., 1985). A case of established IgA nephropathy with subsequent onset of sensorineural deafness is described.

scholarly journals Iga nephropathy

2004 ◽  
Vol 132 (1-2) ◽  
pp. 41-43
Author(s):  
Gordana Basta-Jovanovic
Keyword(s):  
Electron Microscopy ◽  
Nephrotic Syndrome ◽  
Light Microscopy ◽  
Iga Nephropathy ◽  
Immune Complex ◽  
Clinical Manifestations ◽  
Glomerular Disease ◽  
Glomerular Mesangium ◽  
Immune Deposits

IgA nephropathy is glomerular disease first described in 1968 by Berger, named after him Morbus Berger. The disease is characterized by the presence of IgA dominant or codominant imunoglobuline deposits in glomerular mesangium which can be demostrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or microskopic, isolated or combined with proteinuria which can be of nephrotic range. In some cases nephrotic syndrome can be the first clinical presentatio. In 10% renal insuficiency can be present at the onset of the disease. By light microscopy IgA can manifest any of the histologie phenotypes of immune complex mediated prolifferative glomerulonephritis. According to light microscopy findings a classification systeme have been used to categorize the histologie patterns of IgA nephropathy. Glomerular changes in IgA nephropathy are prolifferative and can be focal or diffuse accompanied by crescentic formation in many cases. Immune deposits seen by electron microscopy appear as electron dense deposites most numerous in mesangium.

scholarly journals The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy

Renal Failure ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 334-339
Author(s):  
Ning Guo ◽  
Shengli Liu ◽  
Laurine M Bow ◽  
Xianquan Cui ◽  
Luwei Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Iga Nephropathy ◽  
Rat Model

scholarly journals The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

2018 ◽  
Vol 19 (12) ◽  
pp. 3967 ◽  
Author(s):  
Masa-Ki Inoue ◽  
Takeshi Yamamotoya ◽  
Yusuke Nakatsu ◽  
Koji Ueda ◽  
Yuki Inoue ◽  
...  
Keyword(s):  
Protective Effect ◽  
Xanthine Oxidase ◽  
Iga Nephropathy ◽  
Molecular Mechanisms ◽  
Kidney Diseases ◽  
Elevated Serum ◽  
Glomerular Sclerosis ◽  
Mrna Levels ◽  
Xanthine Oxidase Inhibitor ◽  
Serum Iga

Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although the underlying molecular mechanisms remain unclear. However, to date, neither clinical nor basic research has been carried out to elucidate the efficacy of XO inhibitor administration for IgA nephropathy. We thus investigated whether febuxostat, an XO inhibitor, exerts a protective effect against the development of IgA nephropathy, using gddY mice as an IgA nephropathy rodent model. Eight-week-old gddY mice were provided drinking water with (15 μg/mL) or without febuxostat for nine weeks and then subjected to experimentation. Elevated serum creatinine and degrees of glomerular sclerosis and fibrosis, judged by microscopic observations, were significantly milder in the febuxostat-treated than in the untreated gddY mice, while body weights and serum IgA concentrations did not differ between the two groups. In addition, elevated mRNA levels of inflammatory cytokines such as TNFα, MCP-1, IL-1β, and IL-6, collagen isoforms and chemokines in the gddY mouse kidneys were clearly normalized by the administration of febuxostat. These data suggest a protective effect of XO inhibitors against the development of IgA nephropathy, possibly via suppression of inflammation and its resultant fibrotic changes, without affecting the serum IgA concentration.

Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death

Protective effect of Trypanosoma rangeli against infections with a highly virulent strain of Trypanosoma cruzi

1997 ◽  
Vol 2 (5) ◽  
pp. 482-487 ◽  
Author(s):  
Claudio Zuniga ◽  
Teresa Palau ◽  
Pilar Penin ◽  
Carlos Gamallo ◽  
Jose Antonio de Diego
Keyword(s):  
Trypanosoma Cruzi ◽  
Protective Effect ◽  
Virulent Strain ◽  
Trypanosoma Rangeli ◽  
Highly Virulent

Interstitial inflammation and the expression of apoptotic modulators in iga nephropathy

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A114-A114
Author(s):  
Menahem Sa ◽  
Maguire Ja ◽  
Stein‐Oakley A ◽  
Bailey M ◽  
Dowling J ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Interstitial Inflammation
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