scholarly journals Picryl Chloride-Induced Contact Dermatitis in IQI/Jic Male Mice

2001 ◽  
Vol 14 (3) ◽  
pp. 231-231 ◽  
Author(s):  
Ji-Youn Jung ◽  
Junzo Saegusa ◽  
Koji Uetsuka ◽  
Hiroyuki Nakayama ◽  
Kunio Doi
Keyword(s):  
Contact Dermatitis ◽  
Male Mice ◽  
Picryl Chloride

scholarly journals Comparative Study on Picryl Chloride (PCL)-Induced Contact Dermatitis in Female IQI/Jic and BALB/c Mice

2004 ◽  
Vol 53 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Ji-Youn JUNG ◽  
Junzo SAEGUSA ◽  
Hiroyuki NAKAYAMA ◽  
Kunio DOI
Keyword(s):  
Contact Dermatitis ◽  
Comparative Study ◽  
Picryl Chloride

scholarly journals STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

1940 ◽  
Vol 71 (2) ◽  
pp. 237-245 ◽  
Author(s):  
K. Landsteiner ◽  
M. W. Chase
Keyword(s):  
Contact Dermatitis ◽  
Intraperitoneal Injection ◽  
Chemical Compounds ◽  
Route Of Administration ◽  
Necessary Condition ◽  
Skin Sensitization ◽  
Paraffin Oil ◽  
Simple Chemical ◽  
Picryl Chloride ◽  
Dermal Application

A method has been described by which sensitization to a simple chemical, picryl chloride (2:4:6 trinitrochlorobenzene), can be satisfactorily attained by means of intraperitoneal injection of the compound when killed tubercle bacilli suspended in paraffin oil were used as adjuvant. Sensitivity of the contact dermatitis type results therefrom. It follows that although skin sensitization of this type is most easily obtained by dermal application this route of administration is no necessary condition for such sensitivity.

Ultrastructural features of mast cells in picryl chloride (PCL)-induced contact dermatitis in IQI/Jic mice

2003 ◽  
Vol 54 (4) ◽  
pp. 265-271 ◽  
Author(s):  
Ji-Youn Jung ◽  
Akira Yasoshima ◽  
Junzo Saegusa ◽  
Hiroyuki Nakayama ◽  
Kunio Doi
Keyword(s):  
Contact Dermatitis ◽  
Mast Cells ◽  
Picryl Chloride

scholarly journals STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

1937 ◽  
Vol 66 (3) ◽  
pp. 337-351 ◽  
Author(s):  
K. Landsteiner ◽  
M. W. Chase
Keyword(s):  
Contact Dermatitis ◽  
Strong Evidence ◽  
Guinea Pigs ◽  
Chemical Properties ◽  
Chemical Compounds ◽  
Protein Conjugates ◽  
Chemical Constitution ◽  
Simple Chemical ◽  
Picryl Chloride ◽  
Cutaneous Administration

It has been shown that by the cutaneous administration of simple chemical compounds in small quantities—2:4:6 trinitrochlorobenzene (picryl chloride) and 2:4 dinitrochlorobenzene, the latter a typical incitant of contact dermatitis in man—it is possible to induce true anaphylactic sensitization in guinea pigs, demonstrable by the intravenous injection of protein conjugates and by the Dale technique, using isolated uterine horns. This furnishes strong evidence for the formation of antigenic conjugates following application of substances of simple chemical constitution. Since the anaphylactic state is induced by the same method of administration that gives rise to cutaneous sensitivity, the assumption would appear justified, when one takes into account the chemical properties of the inciting substances, that the formation of conjugated antigens offers an explanation for the skin effects also. In the experiments with picryl chloride, anaphylactic antibodies, and occasionally precipitins, have been demonstrated. The differences between the cutaneous and anaphylactic types of sensitivity are discussed.

Anti-inflammatory Effect of Quercetin on Picryl Chloride-induced Contact Dermatitis in BALB/c Mice

2010 ◽  
Vol 26 (1) ◽  
pp. 7 ◽  
Author(s):  
Hyeong-Jin Kim ◽  
Jin Kim ◽  
So-Jung Kim ◽  
Seung-Ho Lee ◽  
Young-Seok Park ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Picryl Chloride ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2970 ◽  
Author(s):  
Masafumi Noda ◽  
Nasrin Sultana ◽  
Ikue Hayashi ◽  
Mitsuhiro Fukamachi ◽  
Masanori Sugiyama
Keyword(s):  
Contact Dermatitis ◽  
Oral Administration ◽  
Immunoglobulin E ◽  
Interferon Γ ◽  
Interleukin 4 ◽  
Type I ◽  
Inflammatory Reactions ◽  
Type Iv ◽  
Picryl Chloride ◽  
Type Iv Allergy

Allergic disease is one of the most important and common health problems worldwide. We have previously demonstrated that a fig leaf-derived lactic acid bacterium Lactobacillus (Lb.) paracasei IJH-SONE68 produces a novel exopolysaccharide (EPS). Furthermore, we have shown that the EPS inhibits the catalytic activity of hyaluronidase (EC 3.2.1.36) promoting inflammatory reactions. To evaluate the anti-allergy and anti-inflammatory effects of the EPS, in the present study, we employed the picryl-chloride-induced delayed-type (type IV) allergy model mice, which is used to evaluate the contact dermatitis. Oral administration of the EPS was observed to reduce the ear swelling in the model mice. We also observed that the overexpression of ear interleukin-4 (T helper (Th) 2 cytokine) mRNA and the increase in serum immunoglobulin E (IgE) are repressed. However, the expression of interferon-γ (Th1 cytokine) was not accelerated in all of the allergen-challenged model mice. The improvement may be responsible for the Th2 downregulation rather than the Th1 upregulation. In addition, the symptom of immediate-type (type I) allergy model mice was improved by oral administration of the IJH-SONE68 cell (data not shown). We can conclude that the IJH-SONE68-derived EPS is useful to improve the type I and IV allergies including atopic dermatitis.

Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice

2007 ◽  
Vol 62 (2) ◽  
pp. 202-206 ◽  
Author(s):  
Tadashi Fujita ◽  
Takehumi Shiura ◽  
Megumi Masuda ◽  
Masashi Tokunaga ◽  
Atsushi Kawase ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Citrus Unshiu ◽  
Picryl Chloride ◽  
Allergic Effect ◽  
Unripe Fruits

Pharmacologic Modulation of Picryl Chloride-Induced Contact Dermatitis in the Mouse

1991 ◽  
Vol 97 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Philippe Lavaud ◽  
Françoise Rodrigue ◽  
Christian Carré ◽  
Caroline Touvay ◽  
Jean-Michel Mencia-Huerta ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Picryl Chloride ◽  
Pharmacologic Modulation
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