scholarly journals Prediction of Cellular Radiosensitivity from DNA Damage Induced by γ-Rays and Carbon Ion Irradiation in Canine Tumor Cells

2005 ◽  
Vol 67 (11) ◽  
pp. 1089-1095 ◽  
Author(s):  
Seiichi WADA ◽  
Tran Van KHOA ◽  
Yasuhiko KOBAYASHI ◽  
Tomoo FUNAYAMA ◽  
Kikumi OGIHARA ◽  
...  
Keyword(s):  
Dna Damage ◽  
Tumor Cells ◽  
Ion Irradiation ◽  
Cellular Radiosensitivity ◽  
Carbon Ion ◽  
Γ Rays ◽  
Canine Tumor

Low-dose carbon ion irradiation effects on DNA damage and oxidative stress in the mouse testis

2011 ◽  
Vol 47 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Yang Liu ◽  
Jing Long ◽  
Luwei Zhang ◽  
Hong Zhang ◽  
Bin Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Low Dose ◽  
Ion Irradiation ◽  
Mouse Testis ◽  
Irradiation Effects ◽  
Carbon Ion ◽  
And Oxidative Stress

scholarly journals The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams

2015 ◽  
Vol 6 (4) ◽  
pp. 398-409 ◽  
Author(s):  
Shin-ichiro Masunaga ◽  
Akiko Uzawa ◽  
Ryoichi Hirayama ◽  
Yoshitaka Matsumoto ◽  
Yoshinori Sakurai ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ion Beams ◽  
Reactor Neutron ◽  
Carbon Ion ◽  
Neutron Beams ◽  
P53 Status ◽  
Γ Rays

scholarly journals Production of early and late nuclear DNA damage and extracellular 8-oxodG in normal human skin fibroblasts after carbon ion irradiation compared to X-rays

2018 ◽  
Vol 52 ◽  
pp. 116-121 ◽  
Author(s):  
Virginie Prevost ◽  
François Sichel ◽  
Ivannah Pottier ◽  
Alexandre Leduc ◽  
Stéphanie Lagadu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Skin ◽  
Nuclear Dna ◽  
Ion Irradiation ◽  
Skin Fibroblasts ◽  
X Rays ◽  
Human Skin Fibroblasts ◽  
Normal Human Skin ◽  
Carbon Ion ◽  
Normal Human

scholarly journals p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Gersende Alphonse ◽  
Mira Maalouf ◽  
Priscillia Battiston-Montagne ◽  
Dominique Ardail ◽  
Michaël Beuve ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ion Irradiation ◽  
Carbon Ion ◽  
Late Apoptosis

scholarly journals Repair Kinetics of DNA Double Strand Breaks Induced by Simulated Space Radiation

Life ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 341
Author(s):  
Takashi Oizumi ◽  
Rieko Ohno ◽  
Souichiro Yamabe ◽  
Tomoo Funayama ◽  
Asako J. Nakamura
Keyword(s):  
Dna Damage ◽  
Ion Irradiation ◽  
Space Radiation ◽  
Double Strand Breaks ◽  
Dependent Manner ◽  
Dna Double Strand Breaks ◽  
Dsb Repair ◽  
Strand Breaks ◽  
Carbon Ion ◽  
Kinetics Of

Radiation is unavoidable in space. Energetic particles in space radiation are reported to induce cluster DNA damage that is difficult to repair. In this study, normal human fibroblasts were irradiated with components of space radiation such as proton, helium, or carbon ion beams. Immunostaining for γ-H2AX and 53BP1 was performed over time to evaluate the kinetics of DNA damage repair. Our data clearly show that the repair kinetics of DNA double strand breaks (DSBs) induced by carbon ion irradiation, which has a high linear energy transfer (LET), are significantly slower than those of proton and helium ion irradiation. Mixed irradiation with carbon ions, followed by helium ions, did not have an additive effect on the DSB repair kinetics. Interestingly, the mean γ-H2AX focus size was shown to increase with LET, suggesting that the delay in repair kinetics was due to damage that is more complex. Further, the 53BP1 focus size also increased in an LET-dependent manner. Repair of DSBs, characterized by large 53BP1 foci, was a slow process within the biphasic kinetics of DSB repair, suggesting non-homologous end joining with error-prone end resection. Our data suggest that the biological effects of space radiation may be significantly influenced by the dose as well as the type of radiation exposure.

scholarly journals Ridge waveguide lasers in Nd:GGG crystals produced by swift carbon ion irradiation and femtosecond laser ablation

2012 ◽  
Vol 20 (9) ◽  
pp. 9763 ◽  
Author(s):  
Yuechen Jia ◽  
Ningning Dong ◽  
Feng Chen ◽  
Javier R. Vázquez de Aldana ◽  
Sh. Akhmadaliev ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Femtosecond Laser ◽  
Ion Irradiation ◽  
Femtosecond Laser Ablation ◽  
Ridge Waveguide ◽  
Carbon Ion ◽  
Waveguide Lasers ◽  
Ridge Waveguide Lasers

Imaging of fragment particles in water by nuclear spallation during carbon-ion irradiation

2019 ◽  
Vol 64 (13) ◽  
pp. 13NT01 ◽  
Author(s):  
Takuya Yabe ◽  
Masataka Komori ◽  
Takashi Akagi ◽  
Tomohiro Yamashita ◽  
Seiichi Yamamoto
Keyword(s):  
Ion Irradiation ◽  
Carbon Ion
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