scholarly journals Effect of a 7.2% Hypertonic Saline Solution Infusion on Arterial Blood Pressure, Serum Sodium Concentration and Osmotic Pressure in Normovolemic Heifers.

1998 ◽  
Vol 60 (7) ◽  
pp. 799-803 ◽  
Author(s):  
Kazuyuki SUZUKI ◽  
Tadaharu AJITO ◽  
Shigehiro IWABUCHI
Keyword(s):  
Blood Pressure ◽  
Osmotic Pressure ◽  
Hypertonic Saline ◽  
Arterial Blood Pressure ◽  
Serum Sodium ◽  
Saline Solution ◽  
Sodium Concentration ◽  
Serum Sodium Concentration ◽  
Hypertonic Saline Solution ◽  
Arterial Blood

scholarly journals Fluid heating system (SAF®): effects on clinical and biochemistry parameters in dogs submitted to inhalatory anesthesia

2009 ◽  
Vol 24 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Ingrid Bueno Atayde ◽  
Leandro Guimarães Franco ◽  
Marco Augusto Machado Silva ◽  
Lorena Karine Soares ◽  
João Bosco Bittencourt ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Mean Arterial Blood Pressure ◽  
Saline Solution ◽  
Heating System ◽  
Group Effect ◽  
Halothane Anesthesia ◽  
Biochemical Alterations ◽  
Arterial Blood ◽  
Heated Fluid

PURPOSE: To evaluate and describe immediate effects of the infusion of saline solution heated by SAF® in bitches submitted to halothane anesthesia. METHODS: Thirteen bitches were employed and submitted to elective ovariohysterectomy in acclimatized operating room at 22ºC, allocated in two groups: GI, which received non-heated fluid and GII, which received fluid heated at 37ºC by SAF®. The following parameters were evaluated in 30-minutes intervals (M0, M30, M60 and M90): rectal and cutaneous temperatures (TR and TC), cardiac and respiratory frequencies (HR and ƒ), mean arterial blood pressure (MAP), serum concentration of urea, creatinin, serum activities of alanin aminotranspherasis (ALT), alkaline phosphatasis (ALP) and also hypnosis parameters. RESULTS: There were no significant alterations on clinical and biochemical, but there was group effect on mean arterial blood pressure, urea, ALT, ALP and hypnosis parameters. CONCLUSION: The isolated use of Fluid Heating System (SAF®) was not enough to avoid hypothermia or lead to significant clinical and biochemical alterations in bitches submitted to halothane anesthesia.

scholarly journals P1051WHICH MODEL OF DIALYSATE SODIUM PRESCRIPTION TO CHOOSE?

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Natasha Eftimovska-Otovikj ◽  
Natasha Petkovikj ◽  
Elizabeta Poposka ◽  
Olivera Stojceva-Taneva
Keyword(s):  
Blood Pressure ◽  
Serum Sodium ◽  
Sodium Concentration ◽  
Serum Sodium Concentration ◽  
Sodium Balance ◽  
Hypertensive Patients ◽  
Interdialytic Weight Gain ◽  
Sodium Gradient ◽  
Set Up ◽  
Dialysate Sodium

Abstract Background and Aims The dialysate sodium prescription remain unclear as an important component of sodium balance in HD patients Pre-hemodialysis (pre-HD) serum sodium levels can vary among different patients, therefore, a single dialysate sodium prescription may not be appropriate for all patients. Dialysate sodium is one of the most easy changeable parameter which can influence hemodynamic stability. The aim of the study was to investigate whether dialysis patients will have some beneficial effects of prescription of different models of dialysate sodium Method 77 nondiabetic subjects (41 men; 36 women) performed 12 months hemodialysis (HD) sessions with dialysate sodium concentration set up at 138 mmol/L, followed by additional 3 models of dialysate sodium (each model performed 2 months sessions with 2 months standard dialysate sodium between each model) wherein dialysate sodium was set up: model 1: according to pre-HD serum sodium concentration, model 2: according to sodium concentration in UF fluid, model 3: sodium profiling ( from 144 to 136 mmol/L). Blood pressure (BP), interdialytic weight gain (IDWG), thirst score, sodium gradient were analysed. After the standard dialysate sodium hemodialyses, the subjects were divided into 3 groups: normotensive (N=58), hypertensive (N= 14) and hypotensive (N=5) based on the average pre-HD systolic BP during the standard dialysate sodium hemodialyses. Results Model 1: resulted in significantly lower blood pressure (133,61±11.88 versus 153.60±14.26 mmHg; p=0.000) and IDWG (2.21±0.93 versus 1.87±0.92 kg; p=0.018) in hypertensive patients, whereas normotensive patients showed only significant decrease in IDWG (2.21±0.72 versus 2.06±0.65, p=0,004). Hypertensive patients had significant highest sodium gradient compared to other patients (p<0.05), followed by significant increase of 0,6% IDWG confirmed with univariate regression analysis. Thirst score was significantly lower in all patients with individualized-sodium HD and the use of antihypertensive drugs significantly reduced in hypertensive patients during the individualized phase. Model 2: resulted in significantly lower BP in normotensive and hypertensive patients (126.92±9.71 versus 124.08±8.71 mmHg; p=0.000; 153.60±14.26 versus 138.91±8.48 mmHg, accordingly), with no influence on IDWG, thirst score compared to standard dialysate sodium. Model 3: significantly higher BP and IDWG in all 3 groups (normotensive 126.92±9.71 versus 130.20±9.5 mmHg; p=0.001; IDWG 2.21±0.72 versus 2.34±0.82 kg, p=0,005; hypertensive 153.60±14.26 versus 157.58±5.0 mmHg; IDWG 2.21±0.93 versus 2.39±0.74 kg; p=0.005; hipotensive 79.81±11.78 versus 91.09±24.98 mmHg, IDWG 2.53±0.57 versus 2.73±0.15 kg, p=0.005) and significantly higher thirst score in normotensive and hypotensive patients, with no influence in hypertensive patients. Conclusion A reduction of the dialysate sodium concentration based on the pre HD serum sodium level of the patient, reduced the BP, IDWG, thirst score and use of antihypertensive drug compare to dialysate sodium according to sodium concentration in UF or sodium profiling. We recommend prescription of dialysate sodium according to pre HD serum sodium concentration.

scholarly journals Clinical application of 2.16% hypertonic saline solution to correct the blood sodium concentration in diarrheic calves with hyponatremia

2020 ◽  
Vol 82 (11) ◽  
pp. 1585-1588
Author(s):  
Mitsuhide NAKAGAWA ◽  
Kenji TSUKANO ◽  
Yoshiki MURAKAMI ◽  
Marina OTSUKA ◽  
Kazuyuki SUZUKI ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Clinical Application ◽  
Saline Solution ◽  
Sodium Concentration ◽  
Hypertonic Saline Solution ◽  
Diarrheic Calves

scholarly journals Brain Uptake of Myoinositol after Exogenous Administration

2002 ◽  
Vol 13 (5) ◽  
pp. 1255-1260
Author(s):  
Stephen M. Silver ◽  
Barbara M. Schroeder ◽  
Richard H. Sterns
Keyword(s):  
Hypertonic Saline ◽  
Serum Sodium ◽  
Sodium Concentration ◽  
Serum Sodium Concentration ◽  
Organic Osmolytes ◽  
Time Period ◽  
Acute Increase ◽  
The Brain ◽  
Brain Water ◽  
Water Contents

ABSTRACT. An acute increase in plasma tonicity results in an adaptive increase in brain organic osmolyte content, but this process requires several days to occur. Slow reaccumulation of brain organic osmolytes may contribute to osmotic demyelination. It was investigated whether administration of intravenous myoinositol in rats could speed entry of the osmolyte into the brain. Two groups of animals were studied: normonatremic animals and animals with hyponatremia (105 mmol/L) of 3–d duration. Animals were intravenously administered either 1 M NaCl to induce a 25 to 28 mM increase in serum sodium concentration over 200 min or an infusate that maintained serum sodium concentration. In some animals, myoinositol was administered intravenously over the same time period to raise plasma myoinositol levels by 5 to 10 mM. Brain myoinositol, electrolyte, and water contents were determined at the end of the infusions. In both normonatremic and hyponatremic rats, infusion of hypertonic saline without myoinositol or infusion of myoinositol without hypertonic saline did not increase brain myoinositol levels above control levels. In normonatremic animals, concurrent infusion of hypertonic saline and myoinositol increased brain myoinositol levels by about 50% above control levels. Brain myoinositol content in animals with uncorrected hyponatremia was about 50% of that found in normonatremic controls; concurrent infusion of hypertonic saline and myoinositol increased brain myoinositol to levels similar to those found in normonatremic controls. Intravenous infusion of myoinositol did not alter brain water content compared with animals not infused with myoinositol. In conclusion, systemic infusion of myoinositol can rapidly increase brain myoinositol content, but only when plasma tonicity is concomitantly increased.

Acute increases in arterial blood pressure do not reduce plasma vasopressin levels stimulated by angiotensin II or hyperosmolality in rats

2004 ◽  
Vol 287 (1) ◽  
pp. R127-R137 ◽  
Author(s):  
Sean D. Stocker ◽  
Jennifer C. Schiltz ◽  
Alan F. Sved
Keyword(s):  
Blood Pressure ◽  
Hypertonic Saline ◽  
Arterial Blood Pressure ◽  
Ang Ii ◽  
Adrenergic Agonist ◽  
Stimulatory Action ◽  
Arterial Blood ◽  
Plasma Vasopressin ◽  
Acute Increase ◽  
Aortic Cuff

The present study sought to determine whether an acute increase in arterial blood pressure (ABP) reduces plasma vasopressin (VP) levels stimulated by ANG II or hyperosmolality. During an intravenous infusion of ANG II (100 ng·kg−1·min−1), attenuation of the ANG II-evoked increase in ABP with diazoxide or minoxidil did not further enhance plasma VP levels in rats. When VP secretion was stimulated by an infusion of hypertonic saline, coinfusion of the α-adrenergic agonist phenylephrine (PE) significantly increased ABP but did not reduce plasma VP levels. In fact, plasma VP levels were enhanced. The enhancement of plasma VP levels cannot be explained by a direct stimulatory action of PE, as plasma VP levels of isosmotic rats did not change during a similar infusion of PE. An infusion of endothelin-1 in hyperosmotic rats significantly raised ABP but did not reduce plasma VP levels; rather, VP levels increased as observed with PE. In α-chloralose-anesthetized rats infused with hypertonic saline, inflation of an aortic cuff to increase ABP and stimulate arterial baroreceptors did not reduce plasma VP levels. In each experiment, plasma oxytocin levels paralleled plasma VP levels. Collectively, the present findings suggest that an acute increase in ABP does not inhibit VP secretion.

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