scholarly journals Renal Clearance of Endogenous Creatinine, Urea, Sodium, and Potassium in Normal Cats and Cats with Chronic Renal Failure.

1997 ◽  
Vol 59 (7) ◽  
pp. 509-512 ◽  
Author(s):  
Eisaburo DEGUCHI ◽  
Masao AKUZAWA
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Clearance ◽  
Sodium And Potassium

Erythrocyte Sodium and Potassium during the Development of Chronic Renal Failure in Rats

1985 ◽  
Vol 69 (s12) ◽  
pp. 13P-13P
Author(s):  
T.H. Thomas ◽  
C. Mason ◽  
K.M. Illingworth
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Erythrocyte Sodium ◽  
Sodium And Potassium

Renal Clearance of Amino Acids in Patients with Severe Chronic Renal Failure

Nephron ◽  
1978 ◽  
Vol 20 (2) ◽  
pp. 83-89 ◽  
Author(s):  
H. Nádvorníková ◽  
O. Schück ◽  
J. Malý ◽  
J. Pechar ◽  
P. Doberský ◽  
...  
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Clearance

Creatinine Metabolism in Chronic Renal Failure

1980 ◽  
Vol 58 (4) ◽  
pp. 327-335 ◽  
Author(s):  
W. E. Mitch ◽  
V. U. Collier ◽  
M. Walser
Keyword(s):  
Renal Failure ◽  
Body Weight ◽  
Chronic Renal Failure ◽  
Serum Creatinine ◽  
Renal Clearance ◽  
Average Rate ◽  
Specific Radioactivity ◽  
Normal Subjects ◽  
Volume Of Distribution ◽  
Metabolism Rate

1. Creatinine metabolism was studied in nine patients with severe chronic renal failure who were nevertheless in a nearly steady state with respect to their creatinine pool. Labelled creatinine was injected intravenously and the specific radioactivity of creatinine in urine was measured during the ensuing 5–7 days. 2. In each patient, the decline in specific radioactivity with time was a single exponential function after 12 h. The volume of distribution of creatinine averaged 49.1 ± 2.8% body weight. The average rate of creatinine production was 148 μmol day−1 kg−1, which is similar to predicted values for normal subjects of the same age, weight and sex. Creatinine metabolism rate/kg body weight, estimated as the difference between production rate/kg body weight, determined radioisotopically, and creatinine appearance rate (excretion plus accumulation), averaged 42 μmol day−1 kg−1. 3. Total creatinine metabolism rate/kg body weight was correlated with serum creatinine. Thus, as serum creatinine rises, an increasing fraction of the produced creatinine was metabolized rather than excreted. This relationship could account for the diminished creatinine excretion commonly seen in patients with chronic renal failure. 4. Extrarenal clearance (metabolism/serum creatinine) of this magnitude (approximately 31% of renal clearance in these patients) would be an undetectably small fraction of normal renal clearance. This could explain the absence of demonstrable creatinine metabolism in normal subjects. 5. Two pathways of metabolism were identified: a recycling of creatinine to creatine and an irreversible degradation of creatinine to products other than creatine.

Pharmacokinetics of Intravenous and Oral Pindolol in Hypertensive Patients with Chronic Renal Failure

1978 ◽  
Vol 55 (s4) ◽  
pp. 275s-277s
Author(s):  
M. E. Safar ◽  
N. Ph. Chau ◽  
J. A. Levenson ◽  
A. Ch. Simon ◽  
Y. A. Weiss
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Renal Clearance ◽  
Normal Renal Function ◽  
Initial Rate ◽  
Hepatic Clearance ◽  
Hypertensive Patients ◽  
Rate Of Absorption ◽  
Total Body

1. The pharmacokinetics of intravenous and oral pindolol were determined in 24 hypertensive patients with normal or impaired renal function. 2. In patients with normal renal function, the total clearance of the drug was the sum of both the renal and non-renal clearances in equal parts. The non-renal clearance was found to equal the hepatic clearance directly measured from the hepatic extraction ratio and hepatic blood flow. 3. Compared with patients with normal renal function, patients with chronic renal failure exhibited (i) unchanged transfer rate constants and distribution volumes, (ii) decreased total body clearance with decreased renal clearance and unchanged non-renal clearance. 4. Analysis of data obtained after oral administration of the drug by the Loo—Riegelman method showed that the pindolol absorption kinetic was non-linear. Compared with patients with normal renal function, patients with chronic renal failure exhibited (i) a significantly decreased fraction of dose effectively absorbed, (ii) an increased initial rate of absorption. The initial rate of absorption was inversely correlated with creatinine clearance. 5. The study provided evidence that in patients with renal insufficiency, (i) no increase in the metabolism of the drug accompanied the decrease in renal function, and (ii) decreased bio-availability was associated with a reduced fraction of the dose effectively absorbed and an increased rate of absorption.

Changes in the Sodium and Potassium Transporters in the Course of Chronic Renal Failure

2010 ◽  
Vol 115 (4) ◽  
pp. p31-p41 ◽  
Author(s):  
Sejoong Kim ◽  
Nam Ju Heo ◽  
Ji Yong Jung ◽  
Min-Jeong Son ◽  
Hye Ryoun Jang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Potassium Transporters ◽  
Sodium And Potassium

Relation between Plasma Aldosterone Concentration and Renal Handling of Sodium and Potassium, in Particular in Patients with Chronic Renal Failure

Nephron ◽  
1984 ◽  
Vol 37 (2) ◽  
pp. 94-99 ◽  
Author(s):  
Ronald J. Hené ◽  
Hendrik A. Koomans ◽  
Peter Boer ◽  
Jan C. Roos ◽  
Evert J. Dorhout Mees
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Plasma Aldosterone ◽  
Renal Handling ◽  
Plasma Aldosterone Concentration ◽  
Sodium And Potassium
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