scholarly journals Occurrence of a Pig Respiratory Disease Associated with Swine Influenza A (H1N2) Virus in Tochigi Prefecture, Japan

2010 ◽  
Vol 72 (4) ◽  
pp. 481-488 ◽  
Author(s):  
Shuji YONEYAMA ◽  
Tsuyoshi HAYASHI ◽  
Hirokazu KOJIMA ◽  
Yoshihide USAMI ◽  
Masanori KUBO ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Influenza A ◽  
Swine Influenza ◽  
H1n2 Virus

scholarly journals Detection of respiratory viruses in cases of porcine respiratory disease in nurseries.

2021 ◽  
Author(s):  
Gerard Martín-Valls ◽  
Yanli Li ◽  
Ivan Díaz ◽  
Esmeralda Cano ◽  
Silvana Sosa Portugal ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Influenza A ◽  
Swine Influenza ◽  
Respiratory Syndrome Virus ◽  
Influenza B ◽  
Individual Level ◽  
Porcine Circoviruses ◽  
The One ◽  
Respiratory Coronavirus ◽  
Porcine Respiratory

Respiratory disease in weaned pigs is a common problem in the field, with a complex aetiology of both viruses and bacteria. In the present study, we investigated the presence of eleven viruses in nasal swabs collected from nurseries (fifty-five clinical outbreaks) under the suspicion of swine influenza A virus (swIAV) by cough and fever. The other ten viruses included influenza B (IBV) and influenza D viruses (IDV), Porcine reproductive and respiratory syndrome virus (PRRSV), Porcine respiratory coronavirus (PRCV), Porcine cytomegalovirus (PCMV), porcine circoviruses 2 (PCV2), 3 (PCV3) and 4 (PCV), Porcine parainfluenza 1 virus (PPIV1) and Swine orthopneumovirus (SOV). Twenty-nine swIAV-positive cases and twenty-six cases of swIAV-negative respiratory disease were primarily established. IBV, IBD, PCV4 and PPIV1 were not found in any case, while PRCV, SOV, and PCMV were more likely to be found in swIAV-positive nurseries with respiratory disease ( p<0.05) although, globally, PCV3, PRRSV, and PCMV were the most frequently detected agents on herd level. At an individual level, the prevalence of different viruses was: swIAV 48.6%; PRCV 48.0%; PRRSV 31.6%; SOV 33.8%; PCMV 48.3%, PCV2 36.0%; and PCV3 33.0%. Beyond that, it was common to find animals with low Ct values (< 30) for all agents except for PCV2 and PCV3. When analysed the association between different pathogens, PRCV was the one with the most associations. It positively interacted ( p < 0.05) with swIAV and SOV but was negatively associated ( p < 0.05) with PRRSV and PCVM. Besides these, swIAV and PRRSV were negatively related (p < 0.05). Further analysis of suckling pigs showed that circulation of PRCV, PCMV, SOV, and PCV3 started in the maternities, suggesting a role of the sows in the transmission. Overall, our data may contribute to a better understanding of the complex aetiology and the epidemiology of respiratory disease in weaners. This is the first report of SOV in Spain.

scholarly journals Swine influenza A virus subtypes circulating in Brazilian commercial pig herds from 2012 to 2019

2021 ◽  
Author(s):  
Ana Luiza Soares Fraiha ◽  
Ana Carolina Diniz Matos ◽  
João Luis Reis Cunha ◽  
Beatriz Senra Álvares da Silva Santos ◽  
Maria Vitória Chaves Peixoto ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Swine Influenza A Virus

Swine influenza vaccines: current status and future perspectives

2010 ◽  
Vol 11 (1) ◽  
pp. 81-96 ◽  
Author(s):  
Wenjun Ma ◽  
Jürgen A. Richt
Keyword(s):  
Influenza A ◽  
Swine Influenza ◽  
Influenza Viruses ◽  
Current Status ◽  
Economic Losses ◽  
Influenza A Viruses ◽  
Swine Industry ◽  
Effective Strategies ◽  
Swine Disease ◽  
And Control

AbstractSwine influenza is an important contagious disease in pigs caused by influenza A viruses. Although only three subtypes of influenza A viruses, H1N1, H1N2 and H3N2, predominantly infect pigs worldwide, it is still a big challenge for vaccine manufacturers to produce efficacious vaccines for the prevention and control of swine influenza. Swine influenza viruses not only cause significant economic losses for the swine industry, but are also important zoonotic pathogens. Vaccination is still one of the most important and effective strategies to prevent and control influenza for both the animal and human population. In this review, we will discuss the current status of swine influenza worldwide as well as current and future options to control this economically important swine disease.

scholarly journals A Historical Perspective of Influenza A(H1N2) Virus

2014 ◽  
Vol 20 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Naomi Komadina ◽  
Jodie McVernon ◽  
Robert Hall ◽  
Karin Leder
Keyword(s):  
Influenza A ◽  
Historical Perspective ◽  
H1n2 Virus

scholarly journals Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine

2018 ◽  
Vol 14 (12) ◽  
pp. e1007417 ◽  
Author(s):  
Xiaojian Zhang ◽  
Hailiang Sun ◽  
Fred L. Cunningham ◽  
Lei Li ◽  
Katie Hanson-Dorr ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Tissue Tropisms ◽  
Swine Influenza A Virus

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza

Science ◽  
1976 ◽  
Vol 194 (4262) ◽  
pp. 334-335 ◽  
Author(s):  
P Palese ◽  
M. Ritchey ◽  
J. Schulman ◽  
E. Kilbourne
Keyword(s):  
Influenza A Virus ◽  
Vaccine Strain ◽  
Influenza A ◽  
Swine Influenza ◽  
Genetic Composition ◽  
Virus Recombinant

scholarly journals Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge

2020 ◽  
Author(s):  
Jinhwa Lee ◽  
Yonghai Li ◽  
Yuhao Li ◽  
A. Giselle Cino-Ozuna ◽  
Michael Duff ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Live Vaccine ◽  
H3n2 Virus ◽  
Swine Industry ◽  
Vaccine Candidates ◽  
Virus Challenge ◽  
Significant Difference

AbstractSwine influenza is an important disease for the swine industry. Currently used whole inactivated virus (WIV) vaccines can induce vaccine-associated enhanced respiratory disease (VAERD) in pigs when the vaccine strains mismatch with the infected viruses. Live attenuated influenza virus vaccine (LAIV) is effective to protect pigs against homologous and heterologous swine influenza virus infections without inducing VAERD, but has safety concerns due to potential reassortment with circulating viruses. Herein, we used a chimeric bat influenza Bat09:mH3mN2 virus, which contains both surface HA and NA gene open reading frames of the A/swine/Texas/4199-2/1998 (H3N2) and six internal genes from the novel bat H17N10 virus, to develop modified live-attenuated viruses (MLVs) as vaccine candidates which cannot reassort with canonical influenza A viruses by co-infection. Two attenuated MLV vaccine candidates including the virus that expresses a truncated NS1 (Bat09:mH3mN2-NS1-128, MLV1) or expresses both a truncated NS1 and the swine IL-18 (Bat09:mH3mN2-NS1-128-IL-18, MLV2) were generated and evaluated in pigs against a heterologous H3N2 virus using the WIV vaccineb as a control. Compared to the WIV vaccine, both MLV vaccines were able to reduce lesions and virus replication in lungs and limit nasal virus shedding without VAERD, also induced significantly higher levels of mucosal IgA response in lungs and significantly increased numbers of antigen-specific IFN-γ secreting cells against the challenge virus. However, no significant difference was observed in efficacy between the MLV1 and MLV2. These results indicate that bat influenza vectored MLV vaccines can be used as a safe live vaccine to prevent swine influenza.

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