Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza

Science ◽  
1976 ◽  
Vol 194 (4262) ◽  
pp. 334-335 ◽  
Author(s):  
P Palese ◽  
M. Ritchey ◽  
J. Schulman ◽  
E. Kilbourne
Keyword(s):  
Influenza A Virus ◽  
Vaccine Strain ◽  
Influenza A ◽  
Swine Influenza ◽  
Genetic Composition ◽  
Virus Recombinant

scholarly journals Swine influenza A virus subtypes circulating in Brazilian commercial pig herds from 2012 to 2019

2021 ◽  
Author(s):  
Ana Luiza Soares Fraiha ◽  
Ana Carolina Diniz Matos ◽  
João Luis Reis Cunha ◽  
Beatriz Senra Álvares da Silva Santos ◽  
Maria Vitória Chaves Peixoto ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Swine Influenza A Virus

scholarly journals Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine

2018 ◽  
Vol 14 (12) ◽  
pp. e1007417 ◽  
Author(s):  
Xiaojian Zhang ◽  
Hailiang Sun ◽  
Fred L. Cunningham ◽  
Lei Li ◽  
Katie Hanson-Dorr ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Tissue Tropisms ◽  
Swine Influenza A Virus

scholarly journals Nested RT-PCR method for the detection of European avian-like H1 swine influenza A virus

2016 ◽  
Vol 15 (5) ◽  
pp. 1095-1102
Author(s):  
Yan-di WEI ◽  
Xing-yao PEI ◽  
Yuan ZHANG ◽  
Chen-fang YU ◽  
Hong-lei SUN ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Rt Pcr ◽  
Pcr Method ◽  
Swine Influenza A Virus

scholarly journals Kinetics of single and dual simultaneous infection of pigs with swine influenza A virus and porcine reproductive and respiratory syndrome virus

2020 ◽  
Vol 34 (5) ◽  
pp. 1903-1913
Author(s):  
Małgorzata Pomorska‐Mól ◽  
Katarzyna Podgórska ◽  
Ewelina Czyżewska‐Dors ◽  
Hanna Turlewicz‐Podbielska ◽  
Maciej Gogulski ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Respiratory Syndrome Virus ◽  
Simultaneous Infection ◽  
Kinetics Of ◽  
Swine Influenza A Virus

scholarly journals Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Nicole B. Goecke ◽  
Maja Kobberø ◽  
Thomas K. Kusk ◽  
Charlotte K. Hjulsager ◽  
Ken Steen Pedersen ◽  
...  
Keyword(s):  
Real Time ◽  
San Francisco ◽  
Influenza A Virus ◽  
High Throughput ◽  
Real Time Pcr ◽  
Influenza A ◽  
Clinical Signs ◽  
Swine Influenza ◽  
Porcine Cytomegalovirus ◽  
Swine Influenza A Virus

Abstract Background Infectious diseases are of great economic importance in commercial pig production, causing both clinical and subclinical disease, with influence on welfare, productivity, and antibiotic use. The causes of these diseases are often multifactorial and laboratory diagnostics are seldom routinely performed. The aim of the present study was to explore the benefits of monthly pathogen monitoring in nursery and finisher herds and to examine association between laboratory results and observed clinical signs, including coughing and diarrhoea. Three monthly samplings were conducted in three different age groups in six nursery and four finisher production units. For each unit, two pens were randomly selected in each age group and evaluated for coughing and diarrhoea events. Furthermore, faecal sock and oral fluid samples were collected in the selected pens and analysed for 18 respiratory and enteric viral and bacterial pathogens using the high-throughput real-time PCR BioMark HD platform (Fluidigm, South San Francisco, USA). Results In total, 174 pens were sampled in which eight coughing events and 77 diarrhoeic events were observed. The overall findings showed that swine influenza A virus, porcine circovirus 2, porcine cytomegalovirus, Brachyspira pilosicoli, Lawsonia intracellularis, Escherichia coli fimbria types F4 and F18 were found to be prevalent in several of the herds. Association between coughing events and the presence of swine influenza A virus, porcine cytomegalovirus (Cq ≤ 20) or a combination of these were found. Furthermore, an association between diarrhoeic events and the presence of L. intracellularis (Cq ≤ 24) or B. pilosicoli (Cq ≤ 26) was found. Conclusions The use of high-throughput real-time PCR analysis for continuous monitoring of pathogens and thereby dynamics of infections in a pig herd, provided the veterinarian and farmer with an objective knowledge on the distribution of pathogens in the herd. In addition, the use of a high-throughput method in combination with information about clinical signs, productivity, health status and antibiotic consumption, presents a new and innovative way of diagnosing and monitoring pig herds and even to a lower cost than the traditional method.

scholarly journals Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group1

2020 ◽  
Vol 26 (9) ◽  
pp. 2118-2128 ◽  
Author(s):  
Elien Vandoorn ◽  
Isabel Leroux-Roels ◽  
Geert Leroux-Roels ◽  
Anna Parys ◽  
Amy Vincent ◽  
...  
Keyword(s):  
Human Serum ◽  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Serum Samples ◽  
Human Serum Samples ◽  
Swine Influenza A Virus

Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events

2008 ◽  
Vol 131 (2) ◽  
pp. 271-278 ◽  
Author(s):  
Tsan-Yuk Lam ◽  
Chung-Chau Hon ◽  
Zhenggang Wang ◽  
Raymond Kin-Hi Hui ◽  
Fanya Zeng ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Swine Influenza A Virus

scholarly journals Serological evidence of continuing infection of swine in Great Britain with an influenza A virus (H3N2)

1978 ◽  
Vol 80 (3) ◽  
pp. 415-422 ◽  
Author(s):  
M. S. Chapman ◽  
P. H. Lamont ◽  
J. W. Harkness
Keyword(s):  
Great Britain ◽  
Influenza A Virus ◽  
Small Proportion ◽  
Human Population ◽  
Influenza A ◽  
Haemagglutination Inhibition ◽  
Swine Influenza ◽  
Seasonal Fluctuations ◽  
Serological Evidence ◽  
Serum Samples

SummarySerum samples collected from swine and cattle in Great Britain at various times between July 1971 and July 1977 were examined by haemagglutination-inhibition or single radial haemolysis methods for evidence of infection with influenza A (H3N2) viruses. A small proportion of swine sera collected in each year reacted in the tests but there was no evidence of infection in cattle. The significance of the findings is discussed, with particular reference to the seasonal fluctuations in the prevalence of antibody in swine observed during the period of the study, and their possible relevance to influenzal events in the human population. None of the sera tested had antibody to swine influenza strains (HSw1N1).

scholarly journals Reassortants of pandemic influenza A virus H1N1/2009 and endemic porcine HxN2 viruses emerge in swine populations in Germany

2012 ◽  
Vol 93 (8) ◽  
pp. 1658-1663 ◽  
Author(s):  
Elke Starick ◽  
Elke Lange ◽  
Christian Grund ◽  
Elisabeth grosse Beilage ◽  
Stefanie Döhring ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Swine Influenza ◽  
Biological Properties ◽  
Influenza Viruses ◽  
West Germany ◽  
Virus H1n1 ◽  
North West ◽  
Synonymous Mutations

The incursion of the human pandemic influenza A virus H1N1 (2009) (H1N1 pdm) into pig populations and its ongoing co-circulation with endemic swine influenza viruses (SIVs) has yielded distinct human–porcine reassortant virus lineages. The haemagglutinin (HA) gene of H1N1 pdm was detected in 41 influenza virus-positive samples from seven swine herds in north-west Germany in 2011. Eight of these samples yielded virus that carried SIV-derived neuraminidase N2 of three different porcine lineages in an H1N1 pdm backbone. The HA sequences of these viruses clustered in two distinct groups and were distinguishable from human and other porcine H1 pdm by a unique set of eight non-synonymous mutations. In contrast to the human population, where H1N1 pdm replaced seasonal H1N1, this virus seems to co-circulate and interact more intensely with endemic SIV lineages, giving rise to reassortants with as-yet-unknown biological properties and undetermined risks for public health.

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