scholarly journals Ancient Bruises: a Case of Skin Lesions due to Vitamin C Deficiency

2015 ◽  
Vol 2 (LATEST ONLINE) ◽  
Author(s):  
Dipti Rao ◽  
Roeland F. Stolk ◽  
Maaike H. de Blauw ◽  
Marcel M.C. Hovens ◽  
Robert-Jan Hassing
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Acid Level ◽  
Collagen Synthesis ◽  
18Th Century ◽  
Skin Lesions ◽  
Ascorbic Acid Level ◽  
Vitamin C Deficiency ◽  
Specific Symptoms ◽  
The 19Th Century

Scurvy was a common 18th century disease caused by vitamin C deficiency. It presents with multiple non-specific symptoms and can lead to capillary fragility due to impaired collagen synthesis. We report the case of a 63-year-old woman who presented with fatigue, nausea and progressive skin lesions consisting of multiple ecchymoses on the legs as also described in the diary drawings of a navy doctor in the 19th century. The ascorbic acid level was undetectable low in the patient’s serum. However, treatment with 500 mg ascorbic acid daily dramatically improved the skin lesions within 5 days.

PARALLEL STUDIES OF COMPLEMENT AND COAGULATION: I. THE EFFECT OF VITAMIN C

1950 ◽  
Vol 28e (6) ◽  
pp. 262-270 ◽  
Author(s):  
Christine E. Rice ◽  
Paul Boulanger
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Prothrombin Time ◽  
Guinea Pigs ◽  
Significant Variation ◽  
Acid Level ◽  
Ascorbic Acid Level ◽  
Basic Diet

Groups of guinea pigs on a basic diet of commercial rabbit pellets supplemented by fresh green grass or stored roots exhibited marked differences in the ascorbic acid level of their plasma. These differences were not accompanied by any significant variation either in the complement titer of the serum or the prothrombin time of the plasma. Such minor variations as were observed in these two activities did not parallel each other.

scholarly journals Comparison of Vitamin C Content of Commercially Available Fresh Fruits

2019 ◽  
pp. 1-6
Author(s):  
Aneta Popova
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Study Design ◽  
Acid Level ◽  
Design Research ◽  
Current Paper ◽  
Ascorbic Acid Level ◽  
Daily Consumption ◽  
Oxidation Reduction ◽  
Reported Data

Aims: The aim of the current paper is to identify the ascorbic acid level in ten commercially available fruits in order to expand the existing database about fruits rich in Vitamin C and to promote their daily consumption. Study Design:  Research was conducted experimentally. Place and Duration of Study: University of food technologies, Plovdiv, Bulgaria, October 2019. Methodology: Ascorbic acid levels were determined with the use of two oxidation-reduction titration methods – Dichlorophenoliodophenol (DCPIP) and N-Bromosuccinimide (NBS). Results: All studies samples possessed different amounts of ascorbic acid. Both DCPIP and NBS assay resulted in determining strawberries as the fruit with the highest ascorbic acid levels – 55.1 ± 1.6 mg/100 g and 59.8 ± 2.2 mg/100 g respectively. Lowest values were obtained for fig. All results are commensurable to those obtained in other studies. Ascorbic acid levels were as follows: strawberries > grapefruit > pear > green apple > blueberries > quince > banana > plum > white grapes > fig. Conclusion: In this study, ten commercially available fruits were studied for their ascorbic acid levels. Comparison between two titration methods showed moderate differences in the results confirming that the NBS method is more sensitive. All reported data confirms that differences occur, but fruits can be considered sources of vitamin C.

scholarly journals PHENOLICS AND ASCORBIC CONTENTS IN TWO SAGE (Salvia sps. L) SPECIES

2020 ◽  
Vol 8 (Spl-2-AABAS) ◽  
pp. S286-S291
Author(s):  
Estella Bimenyindavyi ◽  
◽  
Olga Arnoldovna Timofeeva ◽  
Keyword(s):  
Ascorbic Acid ◽  
Phenolic Compounds ◽  
Vitamin C ◽  
Acid Level ◽  
Quantitative Estimation ◽  
Ascorbic Acid Level ◽  
Active Compounds ◽  
Plant Parts ◽  
Dry Steppe ◽  
Growing Conditions

This work was carried out for the quantitative estimation of phenolic compounds (soluble phenolic compounds, flavonoids such as quercetin, cynaroside, and avicularin) and ascorbic acid level in the aerial plant parts (leaves and stems) of two sage species viz., Salvia tesquicola (dry-steppe sage) and Salvia verticillata (lilac sage) grown in Tatarstan and Crimea, Kazan, Russia respectively. The highest content of phenolic compounds and the ascorbic acid level was reported in the leaves, while the value of these chemical constitutes was lowest in the stems of both species. Further, it has been shown, that these plants are rich in all investigated chemicals but among these Cynaroside and avicularin are the predominated flavonoids (cynaroside, quercetin, and avicularin). The amount of all studied active compounds differed significantly and it depends on the plant organs, species, and place of growth. Further, the results of the study revealed that the content of soluble phenolic compounds in sage plants did not depend on the species and place of growth while the growing conditions had a greater impact on the amount of flavonoids and vitamin C contents.

scholarly journals Change of Ascorbic Acid Level after Grafting of Tomato Seedlings

1999 ◽  
Vol 54 (9-10) ◽  
pp. 830-833 ◽  
Author(s):  
Akira Wadano ◽  
Mitsuharu Azeta ◽  
Shin-ichi Itotani ◽  
Ai Kanda ◽  
Toshio Iwaki ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Water Stress ◽  
Ascorbate Peroxidase ◽  
Phosphate Buffer ◽  
Acid Level ◽  
Active Oxygen ◽  
Ascorbic Acid Level ◽  
Electrochemical Detector ◽  
Tomato Seedlings ◽  
Severe Water Stress

Grafting is an easy way to produce a new seedling, which can tolerate against various stresses. During the acclimation after grafting, however, the seedlings still suffer a severe water stress. It is well known that water stress produces active oxygen to oxidize ascorbic acid. The concentration of ascorbic acid in the leaves was analyzed by HPLC equipped with an electrochemical detector. The column used was SP-120-5-ODS-BP (DAISO, JAPAN) and elution was performed with 0.1 ᴍ phosphate buffer, pH 3.0. After grafting the seedlings were acclimated under a 6-hr light/dark regimen. The content of ascorbic acid increased gradually during 2 days compared with control. The ascorbate peroxidase showed about constant activity, so the increase of ascorbic acid may be due to its requirement to cure the grafting

scholarly journals P052 Should measurement of ascorbic acid become routine in the management of patients on home parenteral nutrition?

2019 ◽  
Vol 104 (7) ◽  
pp. e2.58-e2
Author(s):  
Amy-Jo Hooley ◽  
Brandy Cox ◽  
David Devadason ◽  
James Hunter
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Parenteral Nutrition ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Micronutrient Deficiency ◽  
Water Soluble ◽  
List Type ◽  
Vitamin C Deficiency

AimTo assess if routine monitoring of vitamin C in long term parenteral nutrition (PN) patients should be routinely carried out, following a case report of a child with clinical vitamin C deficiency.MethodsVitamin C is an essential water soluble nutrient that cannot be synthesised or stored by humans.1 It is a potent antioxidant with anti-inflammatory and immune- supportive roles,1 Vitamin C levels are depleted in critically ill patients, those with restricted diets, smokers, and those with severe digestive disorders. The stability of micronutrients in PN bags is assumed but rarely confirmed, although a decrease in vitamin C content has been observed when there is a long delay between preparation and packaging.2 The patient, a five year old child stable on long term established full PN presented with a one month gradual reduction in mobility, refusal to weight bear, intermittent temperatures, raised CRP and asymptomatic hypercalcaemia on routine bloods. Investigations included bone profile, vitamin D, and parathyroid hormone levels, and routine sepsis screening. Following the extensive work up for systemic disorders and multiple conversations with orthopaedic and radiology specialists, it was discovered that the patient had bilateral metaphyseal irregularities, which were felt to be in keeping with recognised radiological appearances seen in severe vitamin C deficiency. As a result of this her PN bags were made manufactured and analysed in house quality control laboratory using a method involving UV –vis spectrophotometer to analyse the rate of oxidative decomposition of vitamin C within the bags.ResultsIn the United Kingdom children on long term PN programmes are routinely monitored for selected micronutrient deficiency, but not routinely vitamin C. The vitamin C was increased in the PN to three times the baseline dose for this patient, and a dramatic improvement in the patients symptoms were observed within 5 days, and radiological improvement was noted within 6 weeks after commencing treatment. Unfortunately baseline vitamin C levels were not obtained prior to starting treatment, but levels one month later still showed a significant clinical deficiency. The test bags that were analysed within the laboratory showed that on manufacture the bags contained 48.34 mg/L of ascorbic acid, but by 48 hours this had decreased to 8.5 mg/L.ConclusionVitamin C in PN is at significant risk of degradation by oxidation. Awareness of signs and symptoms of micronutrient deficiency and vigilance of micronutrient deficiencies not routinely measured in children on parenteral nutrition is important. Also more research is required into the oxidation rate of vitamin C in PN to establish how much is required within the PN bag to ensure the recommended daily intake in a PN dependent patient.ReferencesCarr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care. 2017;21(1):300. Published 2017 December 11. doi:10.1186/s13054-017-1891-yConroy S, Alsenani A, Sammons H. Factors influencing reported rate of paediatric medication errors. Archives of Disease in Childhood 2014;99:e3. https://adc.bmj.com/content/99/8/e3.19

scholarly journals Studies on Haemoglobin, Serum Calcium and Ascorbic Acid Level in Normal Pregnant, Pre-Eclamptic and Eclamptic Patients

2013 ◽  
pp. 7-14
Author(s):  
Khursheed Jahan ◽  
Maksuda Parvin ◽  
Abdullah Ibn Mafiz
Keyword(s):  
Ascorbic Acid ◽  
Statistical Analysis ◽  
Nutritional Status ◽  
Serum Calcium ◽  
Calcium Level ◽  
Biochemical Parameters ◽  
Serum Calcium Level ◽  
Acid Level ◽  
Ascorbic Acid Level ◽  
Blood Haemoglobin

Background: Nutritional status in relation to selected biochemical parameters and also nutrient intakes in the pre-eclampsia and eclampsia was assessed in 52 patients and compared with that of 52 normal pregnant (NP) women. Serum calcium, ascorbic acid and blood Hb levels in the pre-eclamptic and eclamptic patients were significantly lower than the values of NP women. By unpaired t-test demonstrated in our study, the serum calcium, ascorbic acid and blood Haemoglobin (Hb) level were highly significantly different but not correlated with each other when compared among these groups. However, total statistical analysis revealed that among all the factors studied serum calcium level, ascorbic acid level and blood Hb level have effect on nutritional status of pre-eclampsia and eclampsia.DOI: http://dx.doi.org/10.3329/bjnut.v24i0.14032 Bangladesh J. Nutr. Vol. 24-25 Dec 2011-2012 pp.7-14

Four Food-Frequency Categories of Fruit Intake as a Predictor of Plasma Ascorbic Acid Level in Middle-Aged Japanese Men

1998 ◽  
Vol 8 (6) ◽  
pp. 378-383 ◽  
Author(s):  
Shoichiro Tsugane ◽  
Michael T. Fahey ◽  
Minatsu Kobayashi ◽  
Satoshi Sasaki ◽  
Yoshitaka Tsubono ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Acid Level ◽  
Fruit Intake ◽  
Ascorbic Acid Level ◽  
Middle Aged ◽  
Plasma Ascorbic Acid ◽  
Japanese Men ◽  
Food Frequency

Ascorbate Radical and Ascorbic Acid Level in Human Serum and Age

1983 ◽  
Vol 38 (1) ◽  
pp. 26-30 ◽  
Author(s):  
R. Sasaki ◽  
T. Kurokawa ◽  
S. Tero-kubota
Keyword(s):  
Ascorbic Acid ◽  
Human Serum ◽  
Acid Level ◽  
Ascorbic Acid Level

Reduction in the tissue ascorbic acid level in guinea pigs by thalidomide

1983 ◽  
Vol 96 (1) ◽  
pp. 910-913 ◽  
Author(s):  
B. L. Vaisman ◽  
V. P. Popov ◽  
T. V. Ignat'eva
Keyword(s):  
Ascorbic Acid ◽  
Guinea Pigs ◽  
Acid Level ◽  
Ascorbic Acid Level

INTERRELATIONSHIP OF VITAMINS A AND C ON TISSUE UBIQUINONES AND STEROLS OF RATS AND GUINEA PIGS

1967 ◽  
Vol 45 (6) ◽  
pp. 749-756 ◽  
Author(s):  
W. E. J. Phillips
Keyword(s):  
Ascorbic Acid ◽  
Vitamin A ◽  
Vitamin C ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Vitamin A Deficiency ◽  
Secondary Effect ◽  
Vitamin C Deficiency ◽  
Vitamins A And C ◽  
Combined Deficiency

The effect of administration of ascorbic acid to normal or vitamin A-deficient rats was studied in relation to hepatic levels of ubiquinones and sterols. Similar studies were made on tissues from guinea pigs deficient in vitamin C, vitamin A, or both. Vitamin A deficiency increased the concentration of liver ubiquinones in the rat. Administration of ascorbate did not influence tissue levels of ubiquinones or sterols. Vitamin C deficiency increased the concentration of sterols but not of ubiquinones in the liver of the guinea pig. Vitamin A deficiency did not increase ubiquinones nor did a combined deficiency of vitamins A and C. A secondary effect of vitamin C deficiency in the vitamin A-deficient rat is not the cause of increased ubiquinone levels.

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