INTERRELATIONSHIP OF VITAMINS A AND C ON TISSUE UBIQUINONES AND STEROLS OF RATS AND GUINEA PIGS

1967 ◽  
Vol 45 (6) ◽  
pp. 749-756 ◽  
Author(s):  
W. E. J. Phillips
Keyword(s):  
Ascorbic Acid ◽  
Vitamin A ◽  
Vitamin C ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Vitamin A Deficiency ◽  
Secondary Effect ◽  
Vitamin C Deficiency ◽  
Vitamins A And C ◽  
Combined Deficiency

The effect of administration of ascorbic acid to normal or vitamin A-deficient rats was studied in relation to hepatic levels of ubiquinones and sterols. Similar studies were made on tissues from guinea pigs deficient in vitamin C, vitamin A, or both. Vitamin A deficiency increased the concentration of liver ubiquinones in the rat. Administration of ascorbate did not influence tissue levels of ubiquinones or sterols. Vitamin C deficiency increased the concentration of sterols but not of ubiquinones in the liver of the guinea pig. Vitamin A deficiency did not increase ubiquinones nor did a combined deficiency of vitamins A and C. A secondary effect of vitamin C deficiency in the vitamin A-deficient rat is not the cause of increased ubiquinone levels.

Adrenal Cortical Activity in Scorbutic Monkeys and Guinea Pigs

1957 ◽  
Vol 190 (2) ◽  
pp. 265-267 ◽  
Author(s):  
Sachchidananda Banerjee ◽  
Haobam Devendra Singh
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Rhesus Monkeys ◽  
Cortical Activity ◽  
Considerable Extent ◽  
The Body ◽  
Vitamin C Deficiency ◽  
Normal Controls

Twenty-four-hour urinary excretions of 17-ketosteroids were determined in female guinea pigs and rhesus monkeys during the progress of scurvy. Urinary excretions of both corticosteroids and 17-ketosteroids were also determined in female guinea pigs during the progress of scurvy and in pair-fed normal controls. 17-Ketosteroid excretion diminished in both guinea pigs and monkeys during the early stages of their depletion of ascorbic acid. The excretion of this steroid, however, increased tremendously in all the 3 monkeys and in 7 of 10 guinea pigs, just before the animals died of severe scurvy. In three guinea pigs, the excretion was considerably diminished when they became acutely scorbutic. The excretion of both corticosteroids and 17-ketosteroids increased to a considerable extent in four of five guinea pigs when they became severely scorbutic but in the remaining guinea pig both these excretions diminished when the animal became severely scorbutic. Inanition had little effect on the urinary excretions of these steroids. It is concluded that the levels of steroids of cortical origin in urine may not have any relation to the vitamin C nutrition of the body. Different degrees of stress produced in these animals due to vitamin C deficiency might be responsible for the variation in the excretions of these steroids.

scholarly journals THE RELATION OF VITAMIN C DEFICIENCY TO INTESTINAL TUBERCULOSIS IN THE GUINEA PIG

1933 ◽  
Vol 58 (4) ◽  
pp. 503-512 ◽  
Author(s):  
Mack McConkey ◽  
David T. Smith
Keyword(s):  
Vitamin C ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Intestinal Tuberculosis ◽  
Vitamin C Deficiency ◽  
Adequate Supply ◽  
Adequate Amount

1. Seventy-two adult guinea pigs were fed tuberculous sputum daily for periods ranging from 6 weeks to 4 months. 2. Thirty-seven of these were maintained on a diet partially deficient in vitamin C; twenty-six developed ulcerative intestinal tuberculosis. 3. In the remaining thirty-five animals whose diet was supplemented by an adequate amount of vitamin C only two developed tuberculous ulcers in the intestines. 4. From these studies we conclude that the ingestion of tubercle bacilli by the guinea pig is not the sole factor in the production of intestinal tuberculosis. 5. In our opinion, an adequate supply of vitamin C usually protects the guinea pig against ulcerative intestinal tuberculosis.

Vitamin C activity of D-isoascorbic acid for the guinea pig

1969 ◽  
Vol 47 (12) ◽  
pp. 985-991 ◽  
Author(s):  
Omer Pelletier ◽  
Claude Godin
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Guinea Pig ◽  
Small Proportion ◽  
Acid Content ◽  
Guinea Pigs ◽  
Ascorbic Acid Content ◽  
Similar Response ◽  
Synthetic Diet ◽  
Isoascorbic Acid

Guinea pigs fed with a synthetic diet or a rabbit ration were depleted of vitamin C for 17 days. The scorbutic animals were treated daily during 2 months with 40 mg D-isoascorbic acid (IAA) or 2 mg L-ascorbic acid (AA). Both isomers restored the growth of the animals and caused the disappearance of scorbutic symptoms. For 3 weeks, the two diets gave similar response, after which the animals fed with the rabbit ration grew much less. Animals given IAA ate less and had smaller weight gains than those given AA; this effect was overcome by pair-feeding. Only a small proportion of administered IAA was recovered in the organs and in the urine. The total ascorbic acid content (AA and IAA) of the IAA-treated animals was less than that of the AA-treated animals. The low AA content of the organs of the IAA-treated animals indicated that IAA had no significant sparing action on AA.

scholarly journals Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 749 ◽  
Author(s):  
Stine Hansen ◽  
Jane Jørgensen ◽  
Jens Nyengaard ◽  
Jens Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Synaptic Plasticity ◽  
Vitamin C ◽  
Guinea Pig ◽  
Early Life ◽  
Pyramidal Neurons ◽  
Pig Model ◽  
Vitamin C Deficiency ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Guinea Pig Model

Maternal vitamin C deficiency does not reduce hippocampal volume and β-tubulin III intensity in prenatal Guinea pigs

2016 ◽  
Vol 36 (7) ◽  
pp. 696-702 ◽  
Author(s):  
Stine N. Hansen ◽  
Janne G. Schjoldager ◽  
Maya D. Paidi ◽  
Jens Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Vitamin C ◽  
Guinea Pigs ◽  
Hippocampal Volume ◽  
Maternal Vitamin ◽  
Vitamin C Deficiency ◽  
Β Tubulin
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