Gastric and Peritoneal Involvement of Human Herpes Virus 8 Related Kaposi Sarcoma in a Patient with Acquired Immunodeficiency Syndrome

Kaposi sarcoma is a tumour caused by human herpes virus 8, also known as Kaposi sarcoma-associated herpes virus. It usually affects the skin and oral mucosa; however, it can also sometimes affect the lungs, the liver, the stomach, the bowel, and lymph nodes. Several body sites may be affected simultaneously. The involvement of the tonsils is rare. We described an isolated localization of Kaposi’s sarcoma of the right tonsil in a HIV-positive patient.

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Primary Effusion Lymphoma Occurring in the Setting of Transplanted Patients: A Systematic Review of a Rare, Life-Threatening Post-Transplantation Occurrence

10.21203/rs.3.rs-215295/v1 ◽

2021 ◽

Author(s):

Magda Zanelli ◽

Francesca Sanguedolce ◽

Maurizio Zizzo ◽

Andrea Palicelli ◽

Maria Chiara Bassi ◽

...

Keyword(s):

Herpes Virus ◽

Primary Effusion Lymphoma ◽

Kaposi Sarcoma ◽

Body Cavity ◽

Solid Organ ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Post Transplant ◽

Human Herpes Virus ◽

Herpès Virus

Abstract Background: Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. Primary effusion lymphoma may affect HIV-negative elderly patients from Human Herpes virus 8 endemic regions. So far, rare cases have been reported in transplanted patients. The purpose of our systematic review is to improve our understanding of this type of aggressive lymphoma in the setting of transplantation, focusing on epidemiology, clinical presentation, pathological features, differential diagnosis, treatment and outcome. The role of assessing the viral serological status in donors and recipients is also discussed.Methods: Based on the PRISMA guidelines, we carried out a systematic search on PubMed/MEDLINE, Web of Science, Scopus, EMBASE and Cochrane Library using the search terms “primary effusion lymphoma” and “post-transplant”. Results: Our search identified 13 cases of post-transplant primary effusion lymphoma, predominantly in solid organ transplant recipients (6 kidney, 3 heart, 2 liver and 1 intestine), with only one case after allogenic bone marrow transplantation. Long-term immunosuppression is important in post-transplant primary effusion lymphoma commonly developing several years after transplantation. Kaposi Sarcoma occurred in association with lymphoma in 4 cases of solid organ recipients. The lymphoma showed the classical presentation with body cavity effusions in absence of tumor masses in 10 cases; 2 cases presented as solid masses, lacking effusions and one case as effusions associated with multiple organ involvement. Primary effusion lymphoma occurring in the setting of transplantation was more often Epstein Barr-virus negative. The prognosis was poor. In addition to chemotherapy, reduction of immunosuppressive treatment, was generally attempted.Conclusions: Primary effusion lymphoma is a rare, but often fatal post-transplant complication. Its rarity and the difficulty in achieving the diagnosis may lead to miss this complication. Clinicians should suspect primary effusion lymphoma in transplanted patients, presenting generally with unexplained body cavity effusions, although rare cases with solid masses are described.

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Abstract #994509: Adrenal Insufficiency: A Unique Presentation of Multicentric Castleman Disease with Human Herpes Virus 8 Positivity and Concomitant Kaposi Sarcoma

Endocrine Practice ◽

10.1016/j.eprac.2021.04.478 ◽

2021 ◽

Vol 27 (6) ◽

pp. S3-S4

Author(s):

Banafsheh Motazedi ◽

Meeta Sharma

Keyword(s):

Adrenal Insufficiency ◽

Herpes Virus ◽

Kaposi Sarcoma ◽

Castleman Disease ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Multicentric Castleman Disease ◽

Human Herpes Virus ◽

Herpès Virus

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MOLECULAR DETECTION OF KAPOSI’S SARCOMA ASSOCIATED VIRUS (HUMAN HERPES VIRUS 8) IN SINO-NASAL CARCINOMA TISSUES

10.36295/asro.2020.23434 ◽

2020 ◽

Vol 23 (04) ◽

pp. 286-297

Author(s):

Hind Hamed Shaker ◽

Luma Amer Yasir ◽

Ausama Abed-Alkadum Alajeely ◽

Saad Hasan Mohammed Ali ◽

Shakir H. Mohammed Al-Alwany

Keyword(s):

Kaposi's Sarcoma ◽

Herpes Virus ◽

Molecular Detection ◽

Kaposi’S Sarcoma ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Human Herpes Virus ◽

Herpès Virus ◽

Nasal Carcinoma

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Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence

BMC Cancer ◽

10.1186/s12885-021-08215-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Magda Zanelli ◽

Francesca Sanguedolce ◽

Maurizio Zizzo ◽

Andrea Palicelli ◽

Maria Chiara Bassi ◽

...

Keyword(s):

Systematic Review ◽

Herpes Virus ◽

Primary Effusion Lymphoma ◽

Kaposi Sarcoma ◽

Body Cavity ◽

Solid Organ ◽

Human Herpes Virus 8 ◽

Post Transplant ◽

Human Herpes Virus ◽

Herpès Virus

Abstract Background Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. Primary effusion lymphoma may affect HIV-negative elderly patients from Human Herpes virus 8 endemic regions. So far, rare cases have been reported in transplanted patients. The purpose of our systematic review is to improve our understanding of this type of aggressive lymphoma in the setting of transplantation, focusing on epidemiology, clinical presentation, pathological features, differential diagnosis, treatment and outcome. The role of assessing the viral serological status in donors and recipients is also discussed. Methods We performed a systematic review adhering to the PRISMA guidelines. The literature search was conducted on PubMed/MEDLINE, Web of Science, Scopus, EMBASE and Cochrane Library, using the search terms “primary effusion lymphoma” and “post-transplant”. Results Our search identified 13 cases of post-transplant primary effusion lymphoma, predominantly in solid organ transplant recipients (6 kidney, 3 heart, 2 liver and 1 intestine), with only one case after allogenic bone marrow transplantation. Long-term immunosuppression is important in post-transplant primary effusion lymphoma commonly developing several years after transplantation. Kaposi Sarcoma occurred in association with lymphoma in 4 cases of solid organ recipients. The lymphoma showed the classical presentation with body cavity effusions in absence of tumor masses in 10 cases; 2 cases presented as solid masses, lacking effusions and one case as effusions associated with multiple organ involvement. Primary effusion lymphoma occurring in the setting of transplantation was more often Epstein Barr-virus negative. The prognosis was poor. In addition to chemotherapy, reduction of immunosuppressive treatment, was generally attempted. Conclusions Primary effusion lymphoma is a rare, but often fatal post-transplant complication. Its rarity and the difficulty in achieving the diagnosis may lead to miss this complication. Clinicians should suspect primary effusion lymphoma in transplanted patients, presenting generally with unexplained body cavity effusions, although rare cases with solid masses are described.

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