Air pollution exposure during pregnancy and child attention deficit and hyperactivity disorder symptoms in eight European cohort studies.

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Joan Forns ◽  
Jordi Sunyer ◽  
Raquel García-Esteban ◽  
Ainara Andiarena ◽  
Chiara Badaloní ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Studies ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

scholarly journals Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe

Epidemiology ◽  
2018 ◽  
Vol 29 (5) ◽  
pp. 618-626 ◽  
Author(s):  
Joan Forns ◽  
Jordi Sunyer ◽  
Raquel Garcia-Esteban ◽  
Daniela Porta ◽  
Akhgar Ghassabian ◽  
...  
Keyword(s):  
Air Pollution ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

Air Pollution Exposure during Pregnancy, Depression/Anxiety Symptoms, and Conduct/Aggressive Problems in Children in Eight European Cohort Studies

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Ainhoa Jorcano ◽  
Livia Pierotti ◽  
Malgorzata Joanna Lubczynska ◽  
Michael Jerrett ◽  
Tania Vrijkotte ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Studies ◽  
Anxiety Symptoms ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

AIR POLLUTION EXPOSURE DURING PREGNANCY AND MATERNAL AND FETAL C-REACTIVE PROTEIN LEVELS. THE GENERATION R STUDY

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Edith H van den Hooven ◽  
Vincent WV Jaddoe ◽  
Albert Hofman ◽  
Vincent WV Jaddoe ◽  
Edith H van den Hooven ◽  
...  
Keyword(s):  
Air Pollution ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

scholarly journals Ambient air pollution exposure during pregnancy and cardio-metabolic markers in cord blood: The Healthy Start study

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Chloe Friedman ◽  
Dana Dabelea ◽  
Lizan D. Bloemsma ◽  
Deborah SK Thomas ◽  
Jennifer L. Peel ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cord Blood ◽  
Ambient Air ◽  
Healthy Start ◽  
Ambient Air Pollution ◽  
Metabolic Markers ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

scholarly journals Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
N. D. Saenen ◽  
D. S. Martens ◽  
K. Y. Neven ◽  
R. Alfano ◽  
H. Bové ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Energy Metabolism ◽  
Early Life ◽  
Nitrosative Stress ◽  
Later Life ◽  
Modes Of Action ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

Abstract According to the “Developmental Origins of Health and Disease” (DOHaD) concept, the early-life environment is a critical period for fetal programming. Given the epidemiological evidence that air pollution exposure during pregnancy adversely affects newborn outcomes such as birth weight and preterm birth, there is a need to pay attention to underlying modes of action to better understand not only these air pollution-induced early health effects but also its later-life consequences. In this review, we give an overview of air pollution-induced placental molecular alterations observed in the ENVIRONAGE birth cohort and evaluate the existing evidence. In general, we showed that prenatal exposure to air pollution is associated with nitrosative stress and epigenetic alterations in the placenta. Adversely affected CpG targets were involved in cellular processes including DNA repair, circadian rhythm, and energy metabolism. For miRNA expression, specific air pollution exposure windows were associated with altered miR-20a, miR-21, miR-146a, and miR-222 expression. Early-life aging markers including telomere length and mitochondrial DNA content are associated with air pollution exposure during pregnancy. Previously, we proposed the air pollution-induced telomere-mitochondrial aging hypothesis with a direct link between telomeres and mitochondria. Here, we extend this view with a potential co-interaction of different biological mechanisms on the level of placental oxidative stress, epigenetics, aging, and energy metabolism. Investigating the placenta is an opportunity for future research as it may help to understand the fundamental biology underpinning the DOHaD concept through the interactions between the underlying modes of action, prenatal environment, and disease risk in later life. To prevent lasting consequences from early-life exposures of air pollution, policy makers should get a basic understanding of biomolecular consequences and transgenerational risks.

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