scholarly journals Genome-Wide Analysis of Cadmium-Induced, Germline Mutations in a Long-Term Daphnia pulex Mutation-Accumulation Experiment

2021 ◽  
Vol 129 (10) ◽  
Author(s):  
Nathan Keith ◽  
Craig E. Jackson ◽  
Stephen P. Glaholt ◽  
Kimberly Young ◽  
Michael Lynch ◽  
...  
Keyword(s):  
Daphnia Pulex ◽  
Germline Mutations ◽  
Mutation Accumulation ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

Blood ◽  
2011 ◽  
Vol 117 (15) ◽  
pp. e142-e150 ◽  
Author(s):  
Motohiko Oshima ◽  
Mitsuhiro Endoh ◽  
Takaho A. Endo ◽  
Tetsuro Toyoda ◽  
Yaeko Nakajima-Takagi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Progenitor Cells ◽  
Embryonic Stem ◽  
Es Cell ◽  
Hematopoietic Stem ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
A Genome

Abstract Forced expression of the transcription factor HoxB4 has been shown to enhance the self-renewal capacity of mouse bone marrow hematopoietic stem cells (HSCs) and confer a long-term repopulating capacity to yolk sac and embryonic stem (ES) cell–derived hematopoietic precursors. The fact that ES cell–derived precursors do not repopulate bone marrow without HoxB4 underscores an important role for HoxB4 in the maturation of ES-derived hematopoietic precursors into long-term repopulating HSCs. However, the precise molecular mechanism underlying this process is barely understood. In this study, we performed a genome-wide analysis of HoxB4 using ES cell–derived hematopoietic stem/progenitor cells. The results revealed many of the genes essential for HSC development to be direct targets of HoxB4, such as Runx1, Scl/Tal1, Gata2, and Gfi1. The expression profiling also showed that HoxB4 indirectly affects the expression of several important genes, such as Lmo2, Erg, Meis1, Pbx1, Nov, AhR, and Hemgn. HoxB4 tended to activate the transcription, but the down-regulation of a significant portion of direct targets suggested its function to be context-dependent. These findings indicate that HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing HSCs into repopulating cells. Our list of HoxB4 targets also provides novel candidate regulators for HSCs.

Genome-wide analysis of a long-term evolution experiment with Drosophila

Nature ◽  
2010 ◽  
Vol 467 (7315) ◽  
pp. 587-590 ◽  
Author(s):  
Molly K. Burke ◽  
Joseph P. Dunham ◽  
Parvin Shahrestani ◽  
Kevin R. Thornton ◽  
Michael R. Rose ◽  
...  
Keyword(s):  
Long Term Evolution ◽  
Genome Wide Analysis ◽  
Term Evolution ◽  
Genome Wide ◽  
Evolution Experiment

scholarly journals Genome-wide analysis of long-term evolutionary domestication in Drosophila melanogaster

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mark A. Phillips ◽  
Anthony D. Long ◽  
Zachary S. Greenspan ◽  
Lee F. Greer ◽  
Molly K. Burke ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-wide analysis of tandem repeats in Daphnia pulex - a comparative approach

BMC Genomics ◽  
2010 ◽  
Vol 11 (1) ◽  
pp. 277 ◽  
Author(s):  
Christoph Mayer ◽  
Florian Leese ◽  
Ralph Tollrian
Keyword(s):  
Tandem Repeats ◽  
Daphnia Pulex ◽  
Comparative Approach ◽  
Genome Wide Analysis ◽  
Genome Wide

Integrative genome-wide analysis of long-term effects of doxorubicin on yeast cells

2018 ◽  
Vol 44 ◽  
pp. S113
Author(s):  
H. Taymaz-Nikerel ◽  
E. Karabekmez ◽  
S. Eraslan ◽  
B. Kirdar
Keyword(s):  
Yeast Cells ◽  
Long Term Effects ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-Wide Analysis of Aromatase Inhibitor-Resistant, Tamoxifen-Resistant, and Long-Term Estrogen-Deprived Cells Reveals a Role for Estrogen Receptor

2008 ◽  
Vol 68 (12) ◽  
pp. 4910-4918 ◽  
Author(s):  
Selma Masri ◽  
Sheryl Phung ◽  
Xin Wang ◽  
Xiwei Wu ◽  
Yate-Ching Yuan ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Aromatase Inhibitor ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Tamoxifen Resistant

Genome-Wide Analysis of Polygenic Cardiac Traits in Medaka Inbred Strains

2020 ◽  
Author(s):  
J. Gierten ◽  
T. Fitzgerald ◽  
F. Loosli ◽  
M. Gorenflo ◽  
E. Birney ◽  
...  
Keyword(s):  
Inbred Strains ◽  
Genome Wide Analysis ◽  
Genome Wide
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