scholarly journals Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts

2019 ◽  
Vol 127 (8) ◽  
pp. 087008
Author(s):  
Roxana Khalili ◽  
Scott M. Bartell ◽  
Jonathan I. Levy ◽  
M. Patricia Fabian ◽  
Susan Korrick ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Superfund Site ◽  
Chemical Exposures ◽  
Cohort Data ◽  
New Bedford Harbor

Using Birth Cohort Data to Estimate Prenatal Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Roxana Khalili ◽  
Scott Michael Bartell ◽  
Jonathan Levy ◽  
M. Patricia Fabian ◽  
Susan A. Korrick ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Superfund Site ◽  
Prenatal Exposures ◽  
Cohort Data ◽  
New Bedford Harbor

scholarly journals Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e045868
Author(s):  
Le Gao ◽  
Miriam T Y Leung ◽  
Xue Li ◽  
Celine S L Chui ◽  
Rosa S M Wong ◽  
...  
Keyword(s):  
Hong Kong ◽  
Electronic Health Records ◽  
Birth Cohort ◽  
Descriptive Analysis ◽  
Exact Matching ◽  
Normal Behaviour ◽  
Health Records ◽  
Cohort Data ◽  
Identity Card ◽  
Electronic Health

ObjectivesData linkage of cohort-based data and electronic health records (EHRs) has been practised in many countries, but in Hong Kong there is still a lack of such research. To expand the use of multisource data, we aimed to identify a feasible way of linking two cohorts with EHRs in Hong Kong.MethodsParticipants in the ‘Children of 1997’ birth cohort and the Chinese Early Development Instrument (CEDI) cohort were separated into several batches. The Hong Kong Identity Card Numbers (HKIDs) of each batch were then uploaded to the Hong Kong Clinical Data Analysis and Reporting System (CDARS) to retrieve EHRs. Within the same batch, each participant has a unique combination of date of birth and sex which can then be used for exact matching, as no HKID will be returned from CDARS. Raw data collected for the two cohorts were checked for the mismatched cases. After the matching, we conducted a simple descriptive analysis of attention deficit hyperactivity disorder (ADHD) information collected in the CEDI cohort via the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviour Scale (SWAN) and EHRs.ResultsIn total, 3473 and 910 HKIDs in the birth cohort and CEDI cohort were separated into 44 and 5 batches, respectively, and then submitted to the CDARS, with 100% and 97% being valid HKIDs respectively. The match rates were confirmed to be 100% and 99.75% after checking the cohort data. From our illustration using the ADHD information in the CEDI cohort, 36 (4.47%) individuals had ADHD–Combined score over the clinical cut-off in the SWAN survey, and 68 (8.31%) individuals had ADHD records in EHRs.ConclusionsUsing date of birth and sex as identifiable variables, we were able to link the cohort data and EHRs with high match rates. This method will assist in the generation of databases for future multidisciplinary research using both cohort data and EHRs.

scholarly journals The mobility problem in Britain: new findings from the analysis of birth cohort data

2014 ◽  
Vol 66 (1) ◽  
pp. 93-117 ◽  
Author(s):  
Erzsébet Bukodi ◽  
John H. Goldthorpe ◽  
Lorraine Waller ◽  
Jouni Kuha
Keyword(s):  
Birth Cohort ◽  
Cohort Data ◽  
New Findings ◽  
Mobility Problem

Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution’s impact on childhood asthma

2013 ◽  
Vol 28 (7) ◽  
pp. 597-606 ◽  
Author(s):  
Elaina A. MacIntyre ◽  
Christopher Carlsten ◽  
Meaghan MacNutt ◽  
Elaine Fuertes ◽  
Eric Melén ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Childhood Asthma ◽  
Cohort Data

scholarly journals Deterrence, Work and Crime: Revisiting the Issues with Birth Cohort Data

10.3386/w2508 ◽  
1988 ◽  
Author(s):  
Helen Tauchen ◽  
Ann Dryden Witte ◽  
Harriet Griesinger
Keyword(s):  
Birth Cohort ◽  
Cohort Data

Fate and transport of pcbs at the new bedford harbor superfund site

1996 ◽  
Vol 15 (5) ◽  
pp. 736-745 ◽  
Author(s):  
Laurie S. Garton ◽  
James S. Bonner ◽  
Andrew N. Ernest ◽  
Robin L. Autenrieth
Keyword(s):  
Fate And Transport ◽  
Superfund Site ◽  
New Bedford Harbor

scholarly journals Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Reiko Kishi ◽  
◽  
Atsuko Ikeda-Araki ◽  
Chihiro Miyashita ◽  
Sachiko Itoh ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Birth Outcomes ◽  
Birth Defects ◽  
Chemical Exposure ◽  
Reproductive Hormones ◽  
Mediating Effect ◽  
Children's Health ◽  
Children’S Health ◽  
Serum Folate ◽  
Chemical Exposures

Abstract Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco. Methods The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. In particular, this report provides the latest details from questionnaire surveys, face-to-face examinations, and a collection of biological specimens from children and measurements of their chemical exposures. Results The latest findings indicate different risk factors of parental characteristics on birth outcomes and the mediating effect between socioeconomic status and children that are small for the gestational age. Maternal serum folate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birth size and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones. We also found significant associations between the chemical levels and neuro development, asthma, and allergies. Conclusions Chemical exposure to children can occur both before and after birth. Longer follow-up for children is crucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast, considering shifts in the exposure levels due to regulation is also essential, which may also change the association to health outcomes. This study found that individual susceptibility to adverse health effects depends on the genotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examining molecular biology perspectives. International collaborations can add a new dimension to the current knowledge and provide novel discoveries in the future.

scholarly journals The Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal (PREVAIL) Cohort of U.S. mothers and their children 0-2 years: Methods (Preprint)

2020 ◽  
Author(s):  
Ardythe Morrow ◽  
Mary Staat ◽  
Emily DeFranco ◽  
Monica McNeal ◽  
Allison Cline ◽  
...  
Keyword(s):  
Natural History ◽  
Birth Cohort ◽  
Respiratory Infections ◽  
Serum Antibody ◽  
The United States ◽  
Breastfeeding Initiation ◽  
Cohort Data ◽  
Vaccine Recommendations ◽  
History Of

UNSTRUCTURED Background: Acute gastroenteritis (AGE) and acute respiratory infections (ARI) cause significant pediatric morbidity and mortality. Developing childhood vaccines for norovirus and respiratory syncytial virus (RSV) and optimizing current vaccines for rotavirus and influenza should be guided by birth cohort data that defines the natural history of infection and acquired immune response. Since the U.S. currently lacks contemporary birth cohort data needed for such recommendations, the PREVAIL Cohort study was initiated in Cincinnati, Ohio for this purpose. Methods: Mothers were enrolled in their third trimester of pregnancy, with intensive child follow-up to 2 years. Blood samples were obtained from children at six time points: Birth (cord), 6 weeks, and 6, 12, 18 and 24 months. Whole stool specimens and mid-turbinate nasal swabs were collected weekly and tested by multi-pathogen molecular assays. Saliva, meconium, maternal blood and milk samples were also collected. AGE (>3 loose or watery stools or >1 vomiting episode within 24 hours) and ARI (cough or fever) cases were documented by weekly cell phone surveys to mothers via automated text messaging and review of medical records. Immunization records were obtained from registries and providers. Infection for a pathogen was defined by a PCR-positive stool or nasal swab or rise in serum antibody. Enrollment of 245 mother-child pairs was completed in 2018. Follow-up of study children ends in August 2020. Results: Study participants were 52% white, 43% black, 56% publicly insured. Breastfeeding initiation was 86%. As of March 2020, study children were all >18 months of age and contributed 398 child-years of follow-up. Among the 193 (79%) children remaining under follow-up, median compliance was 95% for weekly text surveys; 74% for weekly samples; and 92% for post-natal blood sample collections. Blood collection was 100% for mothers and 83% for umbilical cord. By maternal report, there were 1.5 AGE and 4.3 ARI cases/child-year. Conclusions: This interim report demonstrates that the PREVAIL Cohort provides intensive mother-child follow-up to document the natural history of enteric and respiratory infections and immunity in children 0-2 years of age in the United States, and will contribute unique data to guide vaccine recommendations. Pathogen testing is ongoing.

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