scholarly journals Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats

2018 ◽  
Vol 126 (9) ◽  
pp. 097005 ◽  
Author(s):  
Krittika Krishnan ◽  
Nitish Mittal ◽  
Lindsay M. Thompson ◽  
Mariana Rodriguez-Santiago ◽  
Christine L. Duvauchelle ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Endocrine Disrupting Chemicals ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Endocrine Disrupting ◽  
F2 Generation

Olfactory Epithelial Metaplasia and Hyperplasia in Female Harlan Sprague–Dawley Rats Following Chronic Treatment with Polychlorinated Biphenyls

2005 ◽  
Vol 33 (3) ◽  
pp. 371-377 ◽  
Author(s):  
Abraham Nyska ◽  
Katsuhiko Yoshizawa ◽  
Micheal P. Jokinen ◽  
Amy E. Brix ◽  
Donald M. Sells ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Chronic Treatment ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Epithelial Metaplasia

Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats

2021 ◽  
Author(s):  
Andrea C Gore ◽  
Lindsay M Thompson ◽  
Mandee Bell ◽  
Jan A Mennigen
Keyword(s):  
Gene Expression ◽  
Polychlorinated Biphenyls ◽  
Expression Profiles ◽  
Endocrine Disrupting Chemicals ◽  
Gene Expression Profiles ◽  
Estradiol Benzoate ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Transgenerational Effects ◽  
Aroclor 1221

Abstract Polychlorinated biphenyls (PCBs) are endocrine-disrupting chemicals (EDCs) with well-established effects on reproduction and behavior in developmentally-exposed (F1) individuals. Because of evidence for transgenerational effects of EDCs on the neuroendocrine control of reproductive physiology, we tested the hypothesis that prenatal PCB exposure leads to unique hypothalamic gene expression profiles in three generations. Pregnant Sprague–Dawley rats were treated on gestational days 16 and 18 with the PCB mixture Aroclor 1221 (A1221), vehicle (3% DMSO in sesame oil), or estradiol benzoate (EB, 50 μg/kg), the latter a positive control for estrogenic effects of A1221. Maternal- and paternal-lineage F2 and F3 generations were bred using untreated partners. The anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC), involved in the hypothalamic control of reproduction, were dissected from F1-F3 females and males, RNA extracted, and gene expression measured in a qPCR array. We detected unique gene expression profiles in each generation, that were sex- and lineage-specific. In the AVPV, treatment significantly changed 10, 25, and 11 transcripts in F1, F2, and F3 generations, whereas 10, 1, and 12 transcripts were changed in these generations in the ARC. In the F1 AVPV and ARC, most affected transcripts were decreased by A1221. In the F2 AVPV, most effects of A1221 were observed in females of the maternal lineage, whereas only Pomc expression changed in the F2 ARC (by EB). The F3 AVPV and ARC were mainly affected by EB. It is notable that results in one generation do not predict results in another, and that lineage was a major determinant in results. Thus, transient prenatal exposure of F1 rats to A1221 or EB can alter hypothalamic gene expression across 3 generations in a sex- and lineage-dependent manner, leading to the conclusion that the legacy of PCBs continues for generations.

scholarly journals The effects of endocrine disrupting chemicals on the human organism

2017 ◽  
Vol 71 (0) ◽  
pp. 0-0
Author(s):  
Karolina Kulik-Kupka ◽  
Justyna Nowak ◽  
Ilona Korzonek-Szlacheta ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Bisphenol A ◽  
Polychlorinated Biphenyls ◽  
Sperm Count ◽  
Biological Fluids ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Food Storage ◽  
Human Organism ◽  
Human Beings ◽  
Endocrine Disrupting

The development of civilization has not only improved the quality of life, but it is also responsible for increasing environmental pollution. Between 80000-100000 previously unknown chemicals have been estimated to circulate in the air. They include substances known as endocrine disrupting chemicals (EDC). These substances can naturally be found in the environment and food, or are classified as pollutants. EDCs are said to change the functionality of the endocrine system and, in this way, exert an influence on other body functions. Substances such as bisphenol A, phthalates, polychlorinated biphenyls and dioxins are part of the endocrine disrupting chemicals. Some of these compounds (bisphenol A, phthalates) are used in the production of daily necessities like plastic food storage containers, bottles, perfumes, and shampoos. Endocrine disrupting chemicals accumulate in the adipose tissue and have been detected in biological fluids, namely serum, urine, breast milk and amniotic fluid. Exposure to EDC may cause many negative health effects. Bisphenol A, for example, can lead to diabetes, obesity, metabolic syndrome, cancer, or fertility disorders. Classified as carcinogens, phthalates can cause reduced sperm count and testosterone levels, as well as damage to the liver, kidneys and the heart. Dioxins have also been found to exhibit carcinogenic properties. Prenatal exposure to polychlorinated biphenyls (PCBs) has been linked to decreased IQ of offspring, among other problems. This article is a review of publications available on the medical databases such as Polish Medical Bibliography and PubMed-NCBI from the years 2005-2016, which covered endocrine disrupting chemicals and their influence on human beings.

scholarly journals Zearalenone endocrine system catch

2005 ◽  
pp. 121-127 ◽  
Author(s):  
Vojislava Bursic ◽  
Verica Juric
Keyword(s):  
Polychlorinated Biphenyls ◽  
Germ Cell ◽  
Organochlorine Pesticides ◽  
Sexual Development ◽  
Gel Electrophoresis ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Testicular Atrophy ◽  
Principal Mechanism ◽  
Endocrine Disrupting

This paper deals with the contamination of our environment with thousands of both natural and man-made chemicals which affect the endocrine system of humans and animals. These so-called endocrine disrupting chemicals (EDCs) are thought to mimic or block the action of hormones and therefore disrupt sexual development in utero. EDCs are organochlorine pesticides, dioxin compounds, polychlorinated biphenyls, alkylpolyethoxylates, plastic additives and phytoestrogens (occurring naturally in foods: isoflavones coumenestans and zearalenone). The structure of zearalenone is similar to the structure of estrogens and it enables binding to the estrogenic receptors. DNA laddering on gel electrophoresis was present 12 h after dosing thus indicating a conclusion that there was apoptosis. Apoptosis is the principal mechanism contributing to germ cell depletion and testicular atrophy following zearalenone exposure.

scholarly journals Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague–Dawley Rats

2016 ◽  
Vol 29 (8) ◽  
pp. 1335-1344 ◽  
Author(s):  
Esra Mutlu ◽  
Lina Gao ◽  
Leonard B. Collins ◽  
Nigel J. Walker ◽  
Hadley J. Hartwell ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Dna Adducts ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Polychlorinated Biphenyls Affect Thyroid Function and Induce Autoimmunity in Sprague-Dawley Rats

2009 ◽  
Vol 41 (06) ◽  
pp. 471-474 ◽  
Author(s):  
J. Y. Gu ◽  
C. H. Qian ◽  
W. Tang ◽  
X. H. Wu ◽  
K. F. Xu ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Thyroid Function ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Endocrine-disrupting chemicals alter the neuromolecular phenotype in F2 generation adult male rats

2019 ◽  
Vol 211 ◽  
pp. 112674 ◽  
Author(s):  
Krittika Krishnan ◽  
Asbiel Hasbum ◽  
Daniel Morales ◽  
Lindsay M. Thompson ◽  
David Crews ◽  
...  
Keyword(s):  
Adult Male ◽  
Endocrine Disrupting Chemicals ◽  
Male Rats ◽  
Generation Adult ◽  
Endocrine Disrupting ◽  
F2 Generation
Sign in / Sign up

Export Citation Format

Share Document