scholarly journals Endocrine-disrupting chemicals alter the neuromolecular phenotype in F2 generation adult male rats

2019 ◽  
Vol 211 ◽  
pp. 112674 ◽  
Author(s):  
Krittika Krishnan ◽  
Asbiel Hasbum ◽  
Daniel Morales ◽  
Lindsay M. Thompson ◽  
David Crews ◽  
...  
Keyword(s):  
Adult Male ◽  
Endocrine Disrupting Chemicals ◽  
Male Rats ◽  
Generation Adult ◽  
Endocrine Disrupting ◽  
F2 Generation

Mixtures of environmentally relevant endocrine disrupting chemicals affect mammary gland development in female and male rats

2015 ◽  
Vol 54 ◽  
pp. 47-57 ◽  
Author(s):  
Karen Riiber Mandrup ◽  
Hanna Katarina Lilith Johansson ◽  
Julie Boberg ◽  
Anne Stilling Pedersen ◽  
Mette Sidsel Mortensen ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Endocrine Disrupting Chemicals ◽  
Male Rats ◽  
Endocrine Disrupting ◽  
Gland Development

Endocrine Disrupting Chemicals and Risk of Testicular Cancer A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Elvira V Bräuner ◽  
Youn-Hee Lim ◽  
Trine Koch ◽  
Cecilie S Uldbjerg ◽  
Laura S Gregersen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Testicular Cancer ◽  
Adult Male ◽  
Meta Analysis ◽  
Endocrine Disrupting Chemicals ◽  
Fetal Life ◽  
Endocrine Disrupting ◽  
Meta Analyses ◽  
Completeness Of Reporting

Abstract The incidence of many hormone-dependent diseases, including testicular cancer, have sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and non-seminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14 th, 2020, in the databases PubMed and Embase® was performed. Among the 279 identified records, 19 were eligible for quality assessment and 10 for further meta-analysis. The completeness of reporting was high across papers, but over 50% were considered subject to potential risk of bias. Mean age at diagnosis was 31.9 years. None considered effects of EDCs multipollutant mixtures. The meta-analyses showed that maternal exposure to combined EDCs was associated with a higher risk of testicular cancer in male offspring (summary RRs: 2.16, (95% CI:1.78-2.62); 1.93 (95% CI:1.49-2.48); 2.78 (95% CI:2.27-3.41) for all, seminoma, non-seminoma respectively). Similarly, high maternal exposures to grouped organochlorines and organo-halogens were associated with higher risk of seminoma and non-seminoma in the offspring. Summary estimates related to postnatal adult male EDC exposures were inconsistent.Maternal but not postnatal adult male, EDC exposures were consistently associated with a higher risk of testicular cancer, particularly risk of non-seminomas. However, the quality of studies was mixed and considering the fields complexity, more prospective studies of prenatal EDC multipollutant mixture exposures and testicular cancer are needed.

scholarly journals Effect of selected endocrine disruptors on gene expression and male urogenital system development in male rats.

2012 ◽  
Vol 31 (1) ◽  
Author(s):  
Sean M. Patrick ◽  
C. De Jager ◽  
M.S. Bornman ◽  
Annie M. Joubert
Keyword(s):  
Gene Expression ◽  
Endocrine Disruptors ◽  
System Development ◽  
Endocrine Disrupting Chemicals ◽  
Male Rats ◽  
Urogenital System ◽  
Endocrine Disrupting ◽  
The Relationship

Endocrine disrupting chemicals may disrupt hormonal processesleading to impaired development. The studies aim was to investigate the relationship betweenvarious EDC exposures and development of urogenital system in male rats across twogenerations.

scholarly journals Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats

2018 ◽  
Vol 126 (9) ◽  
pp. 097005 ◽  
Author(s):  
Krittika Krishnan ◽  
Nitish Mittal ◽  
Lindsay M. Thompson ◽  
Mariana Rodriguez-Santiago ◽  
Christine L. Duvauchelle ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Endocrine Disrupting Chemicals ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Endocrine Disrupting ◽  
F2 Generation

Subchronic co-administration to cadmium, diazinon and selenium causes apparent symptoms of osteoporosis in adult male rats

2014 ◽  
Author(s):  
Radoslav Omelka ◽  
Hana Chovancova ◽  
Ivana Bobonova ◽  
Grzegorz Formicki ◽  
Robert Toman ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Rats
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