scholarly journals Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study

2018 ◽  
Vol 126 (8) ◽  
pp. 087002 ◽  
Author(s):  
Weiye Wang ◽  
Sayoko Moroi ◽  
Kelly Bakulski ◽  
Bhramar Mukherjee ◽  
Marc G. Weisskopf ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Normative Aging Study ◽  
Bone Lead ◽  
Aging Study ◽  
Lead Levels ◽  
Normative Aging

Cumulative Lead Exposure and Risk of Incident Open-Angle Glaucoma: The VA Normative Aging Study

2018 ◽  
Vol 2017 (1) ◽  
pp. 326
Author(s):  
Weiye Wang ◽  
Sayoko Moroi ◽  
Bhramar MUnited Kingdomherjee ◽  
Marc G. Weisskopf ◽  
David Sparrow ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging

BONE LEAD LEVELS IN RELATION TO BASELINE PULSE PRESSURE: THE NORMATIVE AGING STUDY

Epidemiology ◽  
2004 ◽  
Vol 15 (4) ◽  
pp. S149-S150
Author(s):  
David Sparrow ◽  
Scott Weiss ◽  
Augusto Litonjua ◽  
Howard Hu ◽  
Todd Perlstein ◽  
...  
Keyword(s):  
Pulse Pressure ◽  
Normative Aging Study ◽  
Bone Lead ◽  
Aging Study ◽  
Lead Levels ◽  
Normative Aging

scholarly journals Relation of Nutrition to Bone Lead and Blood Lead Levels in Middle-aged to Elderly Men: The Normative Aging Study

1998 ◽  
Vol 147 (12) ◽  
pp. 1162-1174 ◽  
Author(s):  
Y. Cheng ◽  
W. C. Willett ◽  
J. Schwartz ◽  
D. Sparrow ◽  
S. Weiss ◽  
...  
Keyword(s):  
Blood Lead ◽  
Blood Lead Levels ◽  
Middle Aged ◽  
Elderly Men ◽  
Normative Aging Study ◽  
Bone Lead ◽  
Aging Study ◽  
Lead Levels ◽  
Normative Aging

scholarly journals Effect of Dietary Sodium and Potassium Intake on the Mobilization of Bone Lead among Middle-Aged and Older Men: The Veterans Affairs Normative Aging Study

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2750 ◽  
Author(s):  
Xin Wang ◽  
Douglas Kim ◽  
Katherine L. Tucker ◽  
Marc G. Weisskopf ◽  
David Sparrow ◽  
...  
Keyword(s):  
Veterans Affairs ◽  
Urine Samples ◽  
Dietary Sodium ◽  
Potassium Intake ◽  
Normative Aging Study ◽  
Bone Lead ◽  
Aging Study ◽  
Urinary Lead ◽  
Normative Aging ◽  
Sodium And Potassium

Bone is a major storage site as well as an endogenous source of lead in the human body. Dietary sodium and potassium intake may play a role in the mobilization of lead from bone to the circulation. We examined whether association between bone lead and urinary lead, a marker of mobilized lead in plasma, was modified by dietary intake of sodium and potassium among 318 men, aged 48–93 years, in the Veterans Affairs (VA) Normative Aging Study. Dietary sodium and potassium were assessed by flame photometry using 24-h urine samples, and a sodium-to-potassium ratio was calculated from the resulting measures. Patella and tibia bone lead concentrations were measured by K-shell-x-ray fluorescence. Urinary lead was measured by inductively coupled plasma mass spectroscopy in 24-h urine samples. Linear regression models were used to regress creatinine clearance-corrected urinary lead on bone lead, testing multiplicative interactions with tertiles of sodium, potassium, and sodium-to-potassium ratio, separately. After adjustment for age, body mass index, smoking, vitamin C intake, calcium, and total energy intake, participants in the highest tertile of sodium-to-potassium ratio showed 28.1% (95% CI: 12.5%, 45.9%) greater urinary lead per doubling increase in patella lead, whereas those in the second and lowest tertiles had 13.8% (95% CI: −1.7%, 31.7%) and 5.5% (95% CI: −8.0%, 21.0%) greater urinary lead, respectively (p-for-interaction = 0.04). No statistically significant effect modification by either sodium or potassium intake alone was observed. These findings suggest that relatively high intake of sodium relative to potassium may play an important role in the mobilization of lead from bone into the circulation.

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