scholarly journals Cellular and biochemical actions of adrenal glucocorticoid hormones on rat thymic lymphocytes.

1981 ◽  
Vol 38 ◽  
pp. 89-97 ◽  
Author(s):  
D A Young ◽  
B P Voris ◽  
M L Nicholson
Keyword(s):  
Glucocorticoid Hormones ◽  
Adrenal Glucocorticoid

Glucocorticoid Hormones in Stress: Physiological and Pharmacological Actions

Physiology ◽  
1986 ◽  
Vol 1 (2) ◽  
pp. 69-72 ◽  
Author(s):  
A Munck ◽  
PM Guyre
Keyword(s):  
Immune Responses ◽  
Defense Mechanisms ◽  
Pharmacological Effects ◽  
Glucocorticoid Hormones ◽  
Physiological Functions ◽  
Half Century ◽  
Normal Functions ◽  
Fundamental Distinction ◽  
Simple Question ◽  
Adrenal Glucocorticoid

What are the normal functions of the adrenal glucocorticoid hormones? This seemingly simple question has not yet any simple agreed-on answer. In the half-century since the glucocorticoids were distinguished from other cortical steroids, the question of their physiological functions has generated much inconclusive debate. Likewise, questions of their role in disease and therapy lack definitive answers. The authors propose that there is no fundamental distinction between the physiological and pharmacological effects of glucocorticoids and that their inhibitory actions on inflammatory and immune responses are concerned with modulating the body's defense mechanisms.

The effects of adrenal glucocorticoid hormones on transformation by polyoma virus

Virology ◽  
1976 ◽  
Vol 75 (2) ◽  
pp. 492-494 ◽  
Author(s):  
Zelig Rabinowitz ◽  
Vera Morhenn ◽  
Michael B. Mathews
Keyword(s):  
Polyoma Virus ◽  
Glucocorticoid Hormones ◽  
Adrenal Glucocorticoid

scholarly journals PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory

2021 ◽  
Author(s):  
C. Bouarab ◽  
V. Roullot-Lacarrière ◽  
M. Vallée ◽  
A. Le Roux ◽  
C. Guette ◽  
...  
Keyword(s):  
Traumatic Stress ◽  
Predictive Biomarker ◽  
Stress Disorders ◽  
Glucocorticoid Hormones ◽  
Post Traumatic Stress ◽  
Traumatic Stress Disorders ◽  
Post Traumatic ◽  
Very High ◽  
Moderate Stress ◽  
Pai 1

AbstractModerate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.

Sign in / Sign up

Export Citation Format

Share Document