Induced Synthesis of Histamine, Microcirculatory Regulation and the Mechanism of Action of the Adrenal Glucocorticoid Hormones

2015 ◽  
pp. 187-212 ◽  
Author(s):  
Richard W. Schayer
Keyword(s):  
Mechanism Of Action ◽  
Glucocorticoid Hormones ◽  
Adrenal Glucocorticoid

Glucocorticoid Hormones in Stress: Physiological and Pharmacological Actions

Physiology ◽  
1986 ◽  
Vol 1 (2) ◽  
pp. 69-72 ◽  
Author(s):  
A Munck ◽  
PM Guyre
Keyword(s):  
Immune Responses ◽  
Defense Mechanisms ◽  
Pharmacological Effects ◽  
Glucocorticoid Hormones ◽  
Physiological Functions ◽  
Half Century ◽  
Normal Functions ◽  
Fundamental Distinction ◽  
Simple Question ◽  
Adrenal Glucocorticoid

What are the normal functions of the adrenal glucocorticoid hormones? This seemingly simple question has not yet any simple agreed-on answer. In the half-century since the glucocorticoids were distinguished from other cortical steroids, the question of their physiological functions has generated much inconclusive debate. Likewise, questions of their role in disease and therapy lack definitive answers. The authors propose that there is no fundamental distinction between the physiological and pharmacological effects of glucocorticoids and that their inhibitory actions on inflammatory and immune responses are concerned with modulating the body's defense mechanisms.

scholarly journals Dexamethasone reduces cell surface levels of CD11b on human eosinophils

1997 ◽  
Vol 6 (5-6) ◽  
pp. 363-367 ◽  
Author(s):  
A. M. Das ◽  
L. H. K. Lim ◽  
R. J. Flower ◽  
M. Perretti
Keyword(s):  
Flow Cytometry ◽  
Plasma Membrane ◽  
Cell Surface ◽  
Mechanism Of Action ◽  
Allergic Inflammation ◽  
Inhibitory Effect ◽  
Glucocorticoid Hormones ◽  
Glucocorticoid Hormone ◽  
Overnight Incubation ◽  
Lower Expression

Overnight incubation of human eosinophils (Eøs) with the glucocorticoid hormone dexamethasone (DEX; 0.1 μM) resulted in lower expression of the CD11b, but not CD49d, antigen on their plasma membrane, as assessed by flow cytometry. DEX produced a consistent inhibitory effect (ranging from 16% to 20%) when tested at a concentration of 0.1 μM. Eø stimulation with 100 ng/ml eotaxin produced an increase in CD11b (+26%), but not CD11c, levels and concomitantly a reduction (–25%) on CD62L expression. The inhibition exerted by DEX upon CD11b levels was also evident following eotaxin upregulation, with a degree of inhibition similar to that seen on basal levels. These data highlight a novel mechanism of action by which glucocorticoid hormones may be effective in reducing Eø accumulation during allergic inflammation in man.

Evidence for more than one mechanism of action of the glucocorticoid hormones

1982 ◽  
Vol 717 (2) ◽  
pp. 228-235 ◽  
Author(s):  
Bradley T. Keller ◽  
Gregory M. Landes ◽  
Paul A. Kitos
Keyword(s):  
Mechanism Of Action ◽  
Glucocorticoid Hormones

The effects of adrenal glucocorticoid hormones on transformation by polyoma virus

Virology ◽  
1976 ◽  
Vol 75 (2) ◽  
pp. 492-494 ◽  
Author(s):  
Zelig Rabinowitz ◽  
Vera Morhenn ◽  
Michael B. Mathews
Keyword(s):  
Polyoma Virus ◽  
Glucocorticoid Hormones ◽  
Adrenal Glucocorticoid

Mindfulness as Mechanism of Action for Stress and Well-Being Improvements

2007 ◽  
Author(s):  
Shauna L. Shapiro ◽  
Doug Oman ◽  
Carl E. Thoresen ◽  
Thomas G. Plante ◽  
Tim Flinders
Keyword(s):  
Mechanism Of Action ◽  
Well Being
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