scholarly journals Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation

2015 ◽  
Vol 123 (7) ◽  
pp. 679-688 ◽  
Author(s):  
Limin Zhang ◽  
Robert G. Nichols ◽  
Jared Correll ◽  
Iain A. Murray ◽  
Naoki Tanaka ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Aryl Hydrocarbon Receptor ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Receptor Activation ◽  
Metabolic Homeostasis ◽  
Aryl Hydrocarbon

scholarly journals Association of aryl hydrocarbon receptor transactivating activity, a potential biomarker for persistent organic pollutants, with the risk of gestational diabetes mellitus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sunmin Park ◽  
Suk Chon ◽  
So Young Park ◽  
Soojin Yun ◽  
Sei Hyun Baik ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Aryl Hydrocarbon Receptor ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Screening Method ◽  
Atp Production ◽  
Aryl Hydrocarbon ◽  
Potential Biomarker

AbstractPersistent organic pollutants(POPs) are suggested to be potential risk factors for gestational diabetes mellitus(GDM). We examined the hypothesis that the aryl hydrocarbon receptor trans-activating(AhRT) activity, a potential biomarker for the presence of POPs, could be a GDM risk factor in pregnant women. A total of 390 GDM and 100 normal pregnant(non-GDM) subjects in the Korea National Diabetes Program cohort voluntarily participated. We measured AhRT activity and concentrations of ATP and reactive oxygen in the serum collected at the screening of the participants for GDM using recombinant Hepa1c1c7 cells. Odds ratios(ORs) and 95% confidence intervals(CIs) were estimated using multivariable logistic regression models. The sensitivity and specificity of AhRT activity for GDM diagnostics were measured by receiver operating characteristic(ROC) analysis. Body mass index at pre-pregnancy and delivery and systolic blood pressure were significantly higher in the GDM group. AhRT activity was higher, and ATP concentrations were lower in the GDM group than the non-GDM group(P < 0.0001). AhRT activity was significantly higher in the GDM group(OR 29.3, 95% CI 10.9–79.1) compared with non-GDM(P < 0.0001). Serum glucose concentration at 1 h after a 50 g glucose challenge(glucose-50) was moderately correlated with AhRT activity(r2 = 0.387) and negatively correlated with ATP production(r2 =  −0.650). In the ROC curve, AhRT activity had 70.9% sensitivity and 90.0% specificity for glucose-50, a GDM screening method. In conclusion, this study suggests that serum AhRT activity is positively associated with the risk of GDM.

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