scholarly journals The University of Michigan Dioxin Exposure Study: Population Survey Results and Serum Concentrations for Polychlorinated Dioxins, Furans, and Biphenyls

2009 ◽  
Vol 117 (5) ◽  
pp. 811-817 ◽  
Author(s):  
Elizabeth Hedgeman ◽  
Qixuan Chen ◽  
Biling Hong ◽  
Chiung-Wen Chang ◽  
Kristen Olson ◽  
...  
Keyword(s):  
Population Survey ◽  
University Of Michigan ◽  
Serum Concentrations ◽  
Exposure Study ◽  
Study Population ◽  
Survey Results ◽  
Dioxin Exposure ◽  
The University

scholarly journals The University of Michigan Dioxin Exposure Study: Methods for an Environmental Exposure Study of Polychlorinated Dioxins, Furans, and Biphenyls

2009 ◽  
Vol 117 (5) ◽  
pp. 803-810 ◽  
Author(s):  
David H. Garabrant ◽  
Alfred Franzblau ◽  
James Lepkowski ◽  
Brenda W. Gillespie ◽  
Peter Adriaens ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
University Of Michigan ◽  
Study Methods ◽  
Exposure Study ◽  
Dioxin Exposure ◽  
The University

scholarly journals The University of Michigan Dioxin Exposure Study: Predictors of Human Serum Dioxin Concentrations in Midland and Saginaw, Michigan

2009 ◽  
Vol 117 (5) ◽  
pp. 818-824 ◽  
Author(s):  
David H. Garabrant ◽  
Alfred Franzblau ◽  
James Lepkowski ◽  
Brenda W. Gillespie ◽  
Peter Adriaens ◽  
...  
Keyword(s):  
Human Serum ◽  
University Of Michigan ◽  
Exposure Study ◽  
Dioxin Exposure ◽  
The University

scholarly journals 4079 Lessons learned from implementing Quality Improvement (QI) in academic clinical research setting

2020 ◽  
Vol 4 (s1) ◽  
pp. 74-74
Author(s):  
Chin Chin Lee ◽  
DUSHYANTHA JAYAWEERA ◽  
Marjorie Godfrey ◽  
Matthias Salathe ◽  
Jonelle Wright ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Clinical Research ◽  
Research Unit ◽  
Lessons Learned ◽  
Research Teams ◽  
Team Members ◽  
Clinical Research Unit ◽  
Study Population ◽  
Survey Results ◽  
The University

OBJECTIVES/GOALS: We describe here the implementation of a pilot Quality Improvement (QI) program in clinical research processes in order to facilitate translation from bench to community. This presentation will also discuss challenges encountered by the research teams during the implementation of QI activities. METHODS/STUDY POPULATION: Miami CTSI collaborated with University of Kansas’ CTSA to test the implementation of a QI program for clinical research processes. The program has a duration of 1 year and consists of multi-modal training and coaching sessions with different research teams. Six teams comprising of Principal investigators, clinical coordinators, and regulatory specialists participated in the program based in applied clinical microsystem theory science. Team coaches and teams worked together to assess current processes, test new and improved processes, and standardize and disseminate applicable best practices of the QI program. RESULTS/ANTICIPATED RESULTS: The implementation of QI activities in large clinical research settings poses numerous challenges for the research team. We will present survey results from the coaching sessions and follow on feedback from the different teams involved in the program to implement the QI activities. We will describe the modifications and adjustments made to the original conceptual framework of QI program in order for it to be applicable and feasible for the settings of the University of Miami. We will provide recommendations for other academic clinical research centers that are considering implementing a QI program. DISCUSSION/SIGNIFICANCE OF IMPACT: The successful adaptation of a QI process to implement in academic clinical research settings relies on early engagement of the institution leadership, careful selection of team members, as well as developing communication skills to enhance team dynamics as a clinical research unit.

scholarly journals Assessment of Academic Advising: A Cross-Sectional Study

2002 ◽  
Vol 22 (2) ◽  
pp. 50-65 ◽  
Author(s):  
Alice G. Reinarz ◽  
Nathaniel J. Ehrlich
Keyword(s):  
Academic Advising ◽  
Cross Sectional Study ◽  
First Year ◽  
Data Sets ◽  
University Of Michigan ◽  
Academic Advisor ◽  
Cross Sectional ◽  
Student Responses ◽  
Survey Results ◽  
The University

We highlight a study of an academic advising program at the University of Michigan. Students were surveyed via the Internet, and we summarize data obtained in 2001 and 2002. The majority of respondents reported taking actions that they would not have considered without interaction with an academic advisor. These data have been used for staff discussion and program development. By annually adding cohort data to the survey results, we will be able to assess the students as they move through the university and to compare first-year student responses in year-to-year data sets.

scholarly journals 2043

2017 ◽  
Vol 1 (S1) ◽  
pp. 30-30
Author(s):  
Daniel L. Hertz ◽  
Kelley M. Kidwell ◽  
Kiran Vangipuram ◽  
Duxin Sun ◽  
N. Lynn Henry
Keyword(s):  
Treatment Cycle ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
University Of Michigan ◽  
Breast Cancer Patients ◽  
Patient Reported ◽  
Study Population ◽  
The University ◽  
Dose Limiting Toxicity ◽  
Paclitaxel Treatment

OBJECTIVES/SPECIFIC AIMS: Peripheral neuropathy is the dose limiting toxicity of paclitaxel treatment. Paclitaxel pharmacokinetics (PK), specifically the Cmax and amount of time the concentration remains above 0.05 µM (Tc>0.05), have been associated with occurrence of severe, clinician-documented neuropathy. The objective of this study was to confirm that paclitaxel PK predicts progression of patient-reported neuropathy. METHODS/STUDY POPULATION: This observational trial enrolled breast cancer patients receiving weekly 1-hour paclitaxel infusions (80 mg/m2×12 cycles) at the University of Michigan Comprehensive Cancer Center. Paclitaxel concentration was measured via LC/MS in plasma samples collected at the end of (Cmax) and 16–24 hours after (Tc>0.05) first infusion. Patient-reported neuropathy was collected (EORTC CIPN20) at baseline and each cycle. The rate of neuropathy severity increase per treatment cycle is being modeled for each patient. Cmax and Tc>0.05 values will be introduced into the model to confirm that PK independently contributes to neuropathy progression. RESULTS/ANTICIPATED RESULTS: PK and neuropathy data have been collected from 60 patients for ongoing analysis. Our initial model will characterize the expected severity of neuropathy after each cycle of paclitaxel treatment. The PK-neuropathy model will include either PK parameter to validate their contribution to the progression of neuropathy severity during treatment. We anticipate, based on our preliminary analysis of the first 16 patients, that both PK parameters will significantly contribute to the model but Tc>0.05 will be more strongly associated with neuropathy progression. DISCUSSION/SIGNIFICANCE OF IMPACT: This project will generate a model that can be used to predict a patient’s neuropathy severity throughout treatment using a single, conveniently collected and easily measured PK sample during their first cycle. The next steps of this project include identifying genetic and metabolomic biomarkers that predict which patients experienced more severe neuropathy than would be anticipated based on their paclitaxel PK, and a planned interventional trial of personalized paclitaxel dosing to enhance efficacy and/or prevent neuropathy.

scholarly journals 2489 Perceptions of “translation” and the application of research across disciplines at the University of Michigan

2018 ◽  
Vol 2 (S1) ◽  
pp. 85-85
Author(s):  
Misty Gravelin ◽  
Meagan Ramsey ◽  
Kanchan Lota ◽  
George Mashour
Keyword(s):  
Graduate Students ◽  
Translational Research ◽  
Applied Research ◽  
University Of Michigan ◽  
Research Results ◽  
University Policies ◽  
Study Population ◽  
Definition Of ◽  
The University ◽  
Common Barriers

OBJECTIVES/SPECIFIC AIMS: There is no consensus on what constitutes translational research. To effectively support translation of research into practical settings, universities must determine who is involved, in which disciplines, and what results. In addition, it is unclear whether these researchers would see “translational research” as describing their work. METHODS/STUDY POPULATION: A survey assessing perceptions, successes, and barriers to the application of research was distributed to faculty, fellows, and graduate students within the University of Michigan. This survey included a question on the definition of translational research. RESULTS/ANTICIPATED RESULTS: Investigators of every rank and school participated (n=865), and all schools reported forms of applied research. Over 70% of participants said it was important to use research results beyond academia, and those responses represented diverse successes ranging from product development to artistic endeavors. Common barriers to such as lack of time and funding were also widely experienced. The definitions of translational research were divided between strictly health-oriented or broadly focused application. However, both definitions and familiarity with the term differed by field. DISCUSSION/SIGNIFICANCE OF IMPACT: Translation of research is widespread throughout the university, and many would define translational research to include their research discipline. Strategic university policies could benefit society by enhancing translation and application across many disciplines.

Novae in the Magellanic Clouds

1979 ◽  
Vol 46 ◽  
pp. 96-101
Author(s):  
J.A. Graham
Keyword(s):  
Large Magellanic Cloud ◽  
Magellanic Cloud ◽  
Magellanic Clouds ◽  
University Of Michigan ◽  
The Past ◽  
Spectroscopic Information ◽  
Objective Prism ◽  
The University ◽  
Small Cloud ◽  
Low Dispersion

During the past several years, a systematic search for novae in the Magellanic Clouds has been carried out at Cerro Tololo Inter-American Observatory. The Curtis Schmidt telescope, on loan to CTIO from the University of Michigan is used to obtain plates every two weeks during the observing season. An objective prism is used on the telescope. This provides additional low-dispersion spectroscopic information when a nova is discovered. The plates cover an area of 5°x5°. One plate is sufficient to cover the Small Magellanic Cloud and four are taken of the Large Magellanic Cloud with an overlap so that the central bar is included on each plate. The methods used in the search have been described by Graham and Araya (1971). In the CTIO survey, 8 novae have been discovered in the Large Cloud but none in the Small Cloud. The survey was not carried out in 1974 or 1976. During 1974, one nova was discovered in the Small Cloud by MacConnell and Sanduleak (1974).

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