Signaling Quality via Long Lines and Uninformative Prices

2020 ◽  
Vol 22 (3) ◽  
pp. 513-527
Author(s):  
Laurens Debo ◽  
Uday Rajan ◽  
Senthil K. Veeraraghavan
Keyword(s):  
Signaling Quality

Signaling Quality in an E-Commerce Environment

2006 ◽  
Vol 12 (4) ◽  
pp. 11-25 ◽  
Author(s):  
Stan Ernst ◽  
Neal H. Hooker
Keyword(s):  
Signaling Quality

scholarly journals Isoform localization of Dectin-1 regulates the signaling quality of anti-fungal immunity

2017 ◽  
Vol 47 (5) ◽  
pp. 848-859 ◽  
Author(s):  
Mike Fischer ◽  
Jörg P. Müller ◽  
Bärbel Spies-Weisshart ◽  
Christine Gräfe ◽  
Oliver Kurzai ◽  
...  
Keyword(s):  
Signaling Quality ◽  
Fungal Immunity ◽  
Anti Fungal

Signaling Quality Across Different Stages of the Organizational Life Cycle

2014 ◽  
pp. 171-171
Author(s):  
Stefan Hattula ◽  
Maik Hammerschmidt ◽  
Hauke Wetzel ◽  
Hans H. Bauer
Keyword(s):  
Life Cycle ◽  
Organizational Life ◽  
Organizational Life Cycle ◽  
Signaling Quality

Signaling Quality in the Presence of Observational Learning

2019 ◽  
Vol 56 (3) ◽  
pp. 515-534
Author(s):  
Nicolás Figueroa ◽  
Carla Guadalupi
Keyword(s):  
Observational Learning ◽  
Signaling Quality

Facing new challenges in rural tourism: signaling quality via website

2019 ◽  
Vol 21 (4) ◽  
pp. 559-576 ◽  
Author(s):  
Inmaculada Rabadán-Martín ◽  
Francisco Aguado-Correa ◽  
Nuria Padilla-Garrido
Keyword(s):  
Rural Tourism ◽  
New Challenges ◽  
Signaling Quality

Signaling Quality Through Specialization

2008 ◽  
Vol 27 (2) ◽  
pp. 168-184 ◽  
Author(s):  
Ajay Kalra ◽  
Shibo Li
Keyword(s):  
Signaling Quality

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

Blood ◽  
2009 ◽  
Vol 113 (15) ◽  
pp. 3568-3576 ◽  
Author(s):  
Dirk Schmidt-Arras ◽  
Sylvia-Annette Böhmer ◽  
Sina Koch ◽  
Jörg P. Müller ◽  
Lutz Blei ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Transformation ◽  
Intracellular Location ◽  
Er Retention ◽  
Transforming Activity ◽  
Signaling Quality

Abstract The mechanism of cell transformation by Fms-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia (AML) is incompletely understood. The most prevalent activated mutant FLT3 ITD exhibits an altered signaling quality, including strong activation of the STAT5 transcription factor. FLT3 ITD has also been found partially retained as a high-mannose precursor in an intracellular compartment. To analyze the role of intracellular retention of FLT3 for transformation, we have generated FLT3 versions that are anchored in the perinuclear endoplasmic reticulum (ER) by appending an ER retention sequence containing a RRR (R3) motif. ER retention of R3, but not of corresponding A3 FLT3 versions, is shown by biochemical, fluorescence-activated cell sorting, and immunocytochemical analyses. ER anchoring reduced global autophosphorylation and diminished constitutive activation of ERK1/2 and AKT of the constitutively active FLT3 versions. ER anchoring was, however, associated with elevated signaling to STAT3. Transforming activity of the FLT3 D835Y mutant was suppressed by ER anchoring. In contrast, ER-anchored FLT3 ITD retained STAT5-activating capacity and was transforming in vitro and in vivo. The findings highlight another aspect of the different signaling quality of FLT3 ITD: It can transform cells from an intracellular location.

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