Comparison of the Effects of Ca-Mg Carbonate Chewable Tablets with Calcium Carbonate Tablets on Phosphate Binding in Patients on Hemodialysis Taking H2-R Blockers

2019 ◽  
Vol 26 (1) ◽  
pp. 43-49
Author(s):  
Bani Younes , Moh'd Nour Mahmoud ◽  
Hadad , Ayham ◽  
Al Rabadi , Katebh ◽  
Al Hindwai , Mahmoud ◽  
Al Maita , Mahmoud Hammad
Keyword(s):  
Calcium Carbonate ◽  
Phosphate Binding ◽  
Chewable Tablets

scholarly journals A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Atsushi Yaguchi ◽  
Kenji Akahane ◽  
Kumi Tsuchioka ◽  
Saori Yonekubo ◽  
Shota Yamamoto ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Lanthanum Carbonate ◽  
Combined Effect ◽  
Ferric Citrate ◽  
Phosphate Binders ◽  
Phosphate Solution ◽  
Phosphate Binding ◽  
Sevelamer Hydrochloride

Abstract Background Approximately 30% of patients on dialysis received combination therapy for their phosphate binder prescription; however, few studies for combined effects of phosphate binders are reported. For the purpose of evaluating the efficacy of combination therapy, we compared the efficacy of sucroferric oxyhydroxide (PA21) combined with calcium carbonate with that of lanthanum carbonate hydrate, sevelamer hydrochloride, and ferric citrate hydrate combined with calcium carbonate. Methods For in vitro studies, calcium carbonate and the other phosphate binders alone or in combination were stirred in phosphate solution at pH 2–8 for 2 h. After centrifuging the suspension, the phosphorus level in the supernatant was determined. For in vivo studies, rats were orally administered calcium carbonate and the other phosphate binders (except for sevelamer hydrochloride) alone or in combination, followed by oral administration of phosphate solution adjusted to pH 2 or 7. Serum samples were collected from the rats at predetermined timepoints and the serum phosphorus levels were determined and analyzed using a two-way analysis of variance. Results In the in vitro study, the measured phosphate-binding capacity of combining sevelamer hydrochloride, PA21, and lanthanum carbonate hydrate with calcium carbonate was approximately equal to or greater than the theoretical values under most conditions. Furthermore, these combined effects were insensitive to pH in that order. The measured phosphate-binding capacity of ferric citrate hydrate combined with calcium carbonate was smaller than the theoretical values, and the combination did not exhibit efficacy under any of the tested conditions. In the in vivo study, the combined effect of PA21 and calcium carbonate at both pH values and that of lanthanum carbonate hydrate and calcium carbonate at pH 2 were additive. In contrast, the combined effect of lanthanum carbonate hydrate and calcium carbonate at pH 7 and that of ferric citrate hydrate and calcium carbonate at pH 2 were antagonistic. Conclusions These results suggest that coadministration of PA21 and calcium carbonate showed good and relatively stable efficacy throughout the range of the gastrointestinal pH and that combining lanthanum carbonate hydrate and ferric citrate hydrate with calcium carbonate may not produce the expected efficacy under certain conditions.

scholarly journals Effect of Omeprazole on the Phosphate-Binding Capacity of Calcium Carbonate

Nephron ◽  
1995 ◽  
Vol 69 (1) ◽  
pp. 89-90 ◽  
Author(s):  
P. Osler ◽  
P. Raniga ◽  
K. Farrington
Keyword(s):  
Calcium Carbonate ◽  
Binding Capacity ◽  
Phosphate Binding

Ranitidine reduces phosphate binding in dialysis patients receiving calcium carbonate

1996 ◽  
Vol 11 (5) ◽  
pp. 851-853 ◽  
Author(s):  
C. C. Tan ◽  
P. N. Harden ◽  
R. S. C. Rodger ◽  
P. A. Rowe ◽  
R. J. Spooner ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Phosphate Binding ◽  
Dialysis Patients
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