Evaluation of Serum Fibrosis Markers (CTGF) and (IL-17) versus Liver Biopsy for Detection of Hepatic Fibrosis in Egyptian Patients with Chronic Hepatitis C = تقييم دلالات التليف (سي تي جي اف) و(إنترلوكين-17) بمصل الدم مقابل أخذ جزعة كبدية للكشف عن تليف الكبد في المرضى المصريين المصابين بالتهاب الكبد المزمن (ج)

2015 ◽  
Vol 66 (1-3) ◽  
pp. 205-215
Author(s):  
سمر كمال قاسم ◽  
سناء محرم كمال ◽  
مها محمد سلام ◽  
ليلى نابغ محمد ◽  
حنان حسين شحاتة ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Chronic Hepatitis C ◽  
Hepatic Fibrosis ◽  
Egyptian Patients

scholarly journals Assessment of portal venous index as a non-invasive method for diagnosing liver fibrosis in patients with chronic hepatitis C

2012 ◽  
Vol 49 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Haroldo Luis Oliva Gomes Rocha ◽  
Angélica Lemos Debs Diniz ◽  
Valéria Ferreira de Almeida e Borges ◽  
Frederico Chaves Salomão
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Portal Vein ◽  
Chronic Hepatitis C ◽  
Hepatic Fibrosis ◽  
Control Group ◽  
Non Invasive ◽  
Significant Difference ◽  
Spearman Test

CONTEXT: Hepatitis C is an important cause of chronic liver disease worldwide. The grading of hepatic fibrosis in chronic hepatitis C is important for better clinical management. However, until now, liver biopsy is the only test accepted for this purpose, despite their contraindications and complications. New methods for non-invasive assessment of hepatic fibrosis are under investigation. One proposal is the Doppler ultrasound, as a non-invasive, widely available and inexpensive. OBJECTIVE: To compare Doppler parameters of portal vein in patients with chronic hepatitis C with a healthy control group and to correlate these parameters with fibrosis degree obtained by liver biopsy. METHODS: Fifty patients with chronic hepatitis C submitted to liver biopsy and 44 healthy controls had Doppler of the portal vein performed, with the calculation of the portal venous index. We conducted a comparison between the averages of the two groups of portal venous index. For the correlation between portal venous index and fibrosis was employed the Spearman test. RESULTS: There was a difference between the average portal venous index between controls (0.33 ± 0.07) and patients (0.23 ± 0.09) with P<0.001. No difference was observed between the portal venous index in patients with chronic hepatitis C who have significant fibrosis or not. The correlation between the portal venous index and fibrosis degree was reverse and moderate (r =-0.448 P<0.001). The area under the ROC curve was 78.4% (95% CI: 68.8% to 88%). The cutoff for the portal venous index was 0.28 with sensitivity of 73.5% and specificity of 71.1%. CONCLUSION: The portal venous index was useful in distinguishing healthy patients from patients with CHC. However, there was no significant difference in the quantification of degree of fibrosis.

Sign in / Sign up

Export Citation Format

Share Document