Evaluation of Liver Stiffness Measurement by Fibroscan as Compared to Liver Biopsy for Assessment of Hepatic Fibrosis in Children with Chronic Hepatitis C

2013 ◽  
Vol 43 (3) ◽  
pp. 805-819 ◽  
Author(s):  
Mohiee El-Deen Abd El-Aziz Awad ◽  
Gamal Elsayed Shiha ◽  
Fersan Abdallah Sallam ◽  
Amany Mohamed Amd Eltawab
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Chronic Hepatitis C ◽  
Hepatic Fibrosis ◽  
Liver Stiffness ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement

scholarly journals Liver stiffness measurement predicts liver-related events in patients with chronic hepatitis C: A retrospective study

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184404 ◽  
Author(s):  
Ana Zaida Gomez-Moreno ◽  
Daniel Pineda-Tenor ◽  
Maria Angeles Jimenez-Sousa ◽  
Juan Jose Sánchez-Ruano ◽  
Tomas Artaza-Varasa ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Retrospective Study ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Stiffness ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement

M1570 Prospective Comparison of Liver Stiffness Measurement and Lok Index in Chronic Hepatitis C Patients

2008 ◽  
Vol 134 (4) ◽  
pp. A-795
Author(s):  
Ryota Masuzaki ◽  
Ryosuke Tateishi ◽  
Haruhiko Yoshida ◽  
Eriko Goto ◽  
Takahisa Sato ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Stiffness ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement ◽  
Prospective Comparison ◽  
Chronic Hepatitis C Patients

Accuracy of the ElastPQ® Technique for the Assessment of Liver Fibrosis in Patients with Chronic Hepatitis C: a “Real Life” Single Center Study

2016 ◽  
Vol 25 (3) ◽  
pp. 331-335 ◽  
Author(s):  
Giovanna Ferraioli ◽  
Laura Maiocchi ◽  
Raffaella Lissandrin ◽  
Carmine Tinelli ◽  
Annalisa De Silvestri ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Liver Stiffness ◽  
Real Life ◽  
Advanced Fibrosis ◽  
Liver Stiffness Measurement ◽  
Significant Fibrosis ◽  
Stiffness Measurement

Background & Aims: Noninvasive assessment of liver stiffness has been increasingly used to evaluate fibrosis instead of liver biopsy, especially in patients with chronic viral hepatitis. The aim of this study was to assess the performance in staging liver fibrosis of the updated ElastPQ® technique (EPIQ7 ultrasound system, Philips Healthcare, Bothell, WA, USA) in the “real life” setting by using the FibroScan as the reference standard and to understand whether the use of the quality criteria improves the performance of the technique. Methods: This was a cross-sectional study: 278 patients affected by chronic hepatitis C referred for liver stiffness measurement with the FibroScan® 502 Touch device (Echosens, Paris, France) underwent measurements also with the ElastPQ® technique. For the assessment of significant fibrosis (F≥2), advanced fibrosis (F≥3) and cirrhosis (F=4), respectively, we used the cutoffs of 7.0, 9.5 and 12.0 kPa. The diagnostic performance of ElastPQ® was assessed using the area under the ROC (AUROC) curve analysis and was evaluated overall and for cases with (a) 10 measurements and IQR/M≤30%, (b) 5 measurements and IQR/M ≤30%, (c) 10 measurements and IQR/M>30%, (d) 5 measurements and IQR/M>30%. Results: The optimal cutoffs of ElastPQ® for significant fibrosis, advanced fibrosis and cirrhosis were 6.43, 9.54 and 11.34 kPa, respectively. For measurements with an IQR/M≤30%, there was no statistically significant decrease in sensitivity between 10 and 5 measurements (p=0.26, p=0.09, p=0.71, for F≥2, F≥3, and F=4, respectively). Conclusion: The ElastPQ® technique is reliable and accurate for staging liver fibrosis. The number of measurements does not affect the performance. Abbreviations: ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AUROC: area under the ROC curve; BMI: body mass index; GGT: gamma-glutamyl transferase; LR: likelihood ratio; LSM: liver stiffness measurement; pSWE: point shear wave elastography; ROC: receiver operating characteristic; VCTE: vibration controlled transient elastography; VTQ®: virtual touch quantification.

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