Vitamin E Level and Biomarkers of Oxidative Stress in Patients with Hereditary Spherocytosis and Their Relation to Growth and Quality of Life

2017 ◽  
Vol 34 (3-4) ◽  
pp. 173-181
Author(s):  
Mohsen S. El Alfy ◽  
Mohamed T. Hamza ◽  
Fatma Abdel Hamid
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Vitamin E ◽  
Hereditary Spherocytosis ◽  
Biomarkers Of Oxidative Stress

Effects of Vitamin E Depletion/Repletion on Biomarkers of Oxidative Stress in Healthy Aging

2004 ◽  
Vol 1031 (1) ◽  
pp. 361-364 ◽  
Author(s):  
BRIGITTE M. WINKLHOFER-ROOB ◽  
ANDREAS MEINITZER ◽  
MICHAELA MARITSCHNEGG ◽  
JOHANNES M. ROOB ◽  
GHOLAMALI KHOSCHSORUR ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Healthy Aging ◽  
Biomarkers Of Oxidative Stress

Study assessing the efficacy of herbal teas on bone health and quality of life in a population with osteopenia: rooibos actions on melatonin and tulsi actions on quality of life.

2021 ◽  
Vol 4 (2) ◽  
pp. 270-298
Author(s):  
Fahima Munmun ◽  
Alyssa Linden ◽  
Hunter Hanlon ◽  
Hannah Enderby ◽  
Paula Witt-Enderby
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Bone Health ◽  
Human Mesenchymal Stem Cell ◽  
Melatonin Receptors ◽  
Cooperative Effort ◽  
Translational Study ◽  
Before And After

The purpose of the OsTea translational study was to assess the efficacy of teas (tulsi, rooibos, oolong) compared to placebo (coriander) on markers of bone health and quality of life (QOL) in those with osteopenia and on human mesenchymal stem cell (hMSC) differentiation into osteoblasts to identify potential mechanisms of action. Following consumption of tea (3 times/day; 90 days), participants collected a urine sample during the night (10pm-6am) and filled in questionnaires before and after the study. Rooibos consumption demonstrated a significant decrease in urinary CTX levels vs placebo; trended towards increases in nocturnal melatonin levels (p=0.06); significantly decreased serotonin-producing microbes in the gut; and demonstrated trends towards improvements (p=0.09) in QUALIOST emotional parameters. Tulsi consumption primarily affected subjective measures, such as significantly improved scores for PSS, STAI-trait anxiety, and osteoporosis/osteopenia-related parameters in the QUALIOST. To further identify potential mechanisms underlying these actions of rooibos on CTX and melatonin (urinary and gut), rooibos and melatonin effects on human osteoblastogenesis were carried out for 21 days under oxidative stress conditions to mimic osteopenia.  Although both rooibos and melatonin protected against oxidative stress-induced loss of osteoblasts in vitro, their underlying mechanisms were different.  Melatonin, like tulsi and oolong, demonstrated the greatest protection against oxidative stress at days 10-11 of exposure, which was due to effects on hMSC viability and through melatonin receptors. Rooibos, on the other hand, demonstrated protection at days 10-11 and 20-21, which was through signaling mechanisms involved in differentiation processes and not on cell viability. These findings suggest that the clinical actions of rooibos on decreasing CTX levels in a population with osteopenia may be through a cooperative effort between melatonin and rooibos by protecting hMSC viability against oxidative stress-induced loss and by promoting osteoblast differentiation, respectively.  This study also supports the use of tulsi for improving quality of life in a population susceptible to osteoporosis.

Role of Polyherbal Formulations of Medicinal Plants From Himalayan Regions in the Management of Diabetes

2022 ◽  
pp. 212-229
Author(s):  
Ashfaq Ahmad Shah ◽  
Sumaira Qayoom ◽  
Amit Gupta ◽  
Aqueel Ur Rehman
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Polyphenolic Compounds ◽  
Health Concern ◽  
Glucose Measurement ◽  
Diabetes Research ◽  
Cardiovascular Disorders

Current research on phytochemicals is mainly focused on novel phenolic and polyphenolic compounds expressing their potential as therapeutic agents in various diseases like cancer, autoimmune diseases, cardiovascular disorders, diabetes, oxidative stress-related diseases, as well as their properties to inhibit the growth and proliferation of infectious agents. Among the human physiological disorders, one of the most severe endocrine metabolic diseases is Diabetes mellitus which is a clinical disease distinguished by a deficit in the production of insulin or resistance to the action of insulin. Globally, diabetes is an increasing health concern which is now emerging as an epidemic. About 700-800 plants are exhibiting anti-diabetic activity that has been studied. As far as nanotechnology in diabetes research is concerned, it has made possible the buildout of novel glucose measurement as well as insulin delivery modalities that possess the potential to excellently enhance the quality of life of the diabetic patient.

scholarly journals No effect of vitamin E on oxidative parameters or quality of life in children with transfusion-dependent thalassemia

2016 ◽  
Vol 1 (4) ◽  
pp. 75-79
Author(s):  
Malai Wongchanchailert ◽  
Ladda Mo-suwan ◽  
Ruchaneekorn W. Kalpravidh ◽  
Thirachit Chotsampancharoen ◽  
Penjamaporn Apiromrak ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin E

scholarly journals Potential Benefits of Ameliorating Metabolic and Nutritional Abnormalities in People With Profound Developmental Disabilities

2017 ◽  
Vol 10 ◽  
pp. 117863881771645
Author(s):  
Norris R Glick ◽  
Milton H Fischer
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Amino Acids ◽  
Developmental Disabilities ◽  
Mead Acid ◽  
Other Substances ◽  
Adrenic Acid ◽  
Potential Benefits ◽  
Cell Implantation

Background: People with profound developmental disabilities have some of the most severe neurological impairments seen in society, have accelerated mortality due to huge medical challenges, and yet are often excluded from scientific studies. They actually have at least 2 layers of conditions: (1) the original disability and (2) multiple under-recognized and underexplored metabolic and nutritional imbalances involving minerals (calcium, zinc, and selenium), amino acids (taurine, tryptophan), fatty acids (linoleic acid, docosahexaenoic acid, arachidonic acid, adrenic acid, Mead acid, plasmalogens), carnitine, hormones (insulinlike growth factor 1), measures of oxidative stress, and likely other substances and systems. Summary: This review provides the first list of metabolic and nutritional abnormalities commonly found in people with profound developmental disabilities and, based on the quality of life effects of similar abnormalities in neurotypical people, indicates the potential effects of these abnormalities in this population which often cannot communicate symptoms. Key messages: We propose that improved understanding and management of these disturbed mechanisms would enhance the quality of life of people with profound developmental disabilities. Such insights may also apply to people with other conditions associated with disability, including some diseases requiring stem cell implantation and living in microgravity.

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