Effects of Vitamin E Depletion/Repletion on Biomarkers of Oxidative Stress in Healthy Aging

2004 ◽  
Vol 1031 (1) ◽  
pp. 361-364 ◽  
Author(s):  
BRIGITTE M. WINKLHOFER-ROOB ◽  
ANDREAS MEINITZER ◽  
MICHAELA MARITSCHNEGG ◽  
JOHANNES M. ROOB ◽  
GHOLAMALI KHOSCHSORUR ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Healthy Aging ◽  
Biomarkers Of Oxidative Stress

Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men

2003 ◽  
Vol 34 (12) ◽  
pp. 1575-1588 ◽  
Author(s):  
Jennifer M Sacheck ◽  
Paul E Milbury ◽  
Joseph G Cannon ◽  
Ronenn Roubenoff ◽  
Jeffrey B Blumberg
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Eccentric Exercise ◽  
Elderly Men ◽  
Biomarkers Of Oxidative Stress

Comparison of lycopene and tomato effects on biomarkers of oxidative stress in vitamin E deficient rats

2007 ◽  
Vol 46 (8) ◽  
pp. 468-475 ◽  
Author(s):  
Delphine Gitenay ◽  
Bernard Lyan ◽  
Mathieu Rambeau ◽  
Andrzej Mazur ◽  
Edmond Rock
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Biomarkers Of Oxidative Stress

Urinary Biomarker of Vitamin E Status Is Negatively Correlated with Biomarkers of Oxidative Stress in Obese Children

2012 ◽  
Vol 53 ◽  
pp. S110
Author(s):  
Scott W Leonard ◽  
Stefanie B Murer ◽  
Isabelle Aeberli ◽  
Christian P Braegger ◽  
Alan W Taylor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Urinary Biomarker ◽  
Obese Children ◽  
Vitamin E Status ◽  
Biomarkers Of Oxidative Stress

Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?

2019 ◽  
Vol 70 (1) ◽  
pp. 78-83
Author(s):  
Alexandra Totan ◽  
Daniela Gabriela Balan ◽  
Daniela Miricescu ◽  
Radu Radulescu ◽  
Iulia Ioana Stanescu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Therapeutic Potential ◽  
Plga Nanoparticles ◽  
Diet Group ◽  
Normal Diet ◽  
Oxidative Stress Biomarkers ◽  
Promising Alternative ◽  
Nonalcoholic Fatty Liver ◽  
High Caloric Diet

Oxidative stress (OS) plays an important role in NAFLD molecular mechanism. Nanoencapsulation represents a novel strategy to enhance therapeutic potential of conventional drugs. Our study analyses the encapsulated vitamin E effect on lipid metabolism and oxidative stress biomarkers in NAFLD rats. Animals were divided into 3 groups : G1 - the normal diet group; G2- the high caloric diet group ; G3 - high-caloric diet group receiving PLGA-vit E, 50 mg / kg. Serum advanced human oxidative protein (AOPP), total antioxidant capacity (TAC) and vitamin E were analysed using ELISA technique. Our results showed significant increase of G2 GPT, ALP, GGT, TG, glucose, TC and AOPP, versus G1 ( P [ 0.05) and a significant decrease of G2 serum TAC and vitamin E versus G1 results ( p = 0.01 and 0.01). Vitamin E nanoparticles (G3) caused a significant increase of TAC and significant decrease of serum AOPP, versus G2 (p [ 0.01). Results showed a significant reduction of GPT, GGT, ALP, TG and total cholesterol ( p [0.05) in G3 versus G2. PLGA nanoparticles should be considered an attractive and promising alternative to improve the bioavailability and biological activity of vitaminE.

scholarly journals Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging

2021 ◽  
Vol 22 (12) ◽  
pp. 6379
Author(s):  
Elisa Roda ◽  
Erica Cecilia Priori ◽  
Daniela Ratto ◽  
Fabrizio De Luca ◽  
Carmine Di Iorio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Aging ◽  
Molecular Layer ◽  
Dietary Supplementation ◽  
Purkinje Neurons ◽  
Geriatric Syndrome ◽  
Oral Supplementation ◽  
Erinacine A ◽  
And Oxidative Stress

Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., inflammaging. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of H. erinaceus, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathways, were assessed focusing on senescent frail animals. H. erinaceus partially recovered the aged-related decline of locomotor performances. Histopathological analyses paralleled by immunocytochemical evaluation of specific molecules strengthened the neuroprotective role of H. erinaceus able to ameliorate cerebellar alterations, i.e., milder volume reduction, slighter molecular layer thickness decrease and minor percentage of shrunken Purkinje neurons, also diminishing inflammation and oxidative stress in frail mice while increasing a key longevity regulator and a neuroprotective molecule. Thus, our present findings demonstrated the efficacy of a non-pharmacological approach, based on the dietary supplementation using H. erinaceus extract, which represent a promising adjuvant therapy to be associated with conventional geriatric treatments.

scholarly journals Isoprostanes in Veterinary Medicine: Beyond a Biomarker

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 145
Author(s):  
Ashley K. Putman ◽  
G. Andres Contreras ◽  
Lorraine M. Sordillo
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Veterinary Medicine ◽  
Biological Fluids ◽  
Biological Action ◽  
Clinical Applications ◽  
Animal Medicine ◽  
Inflammatory Processes ◽  
Oxidized Products ◽  
Biomarkers Of Oxidative Stress

Oxidative stress has been associated with many pathologies, in both human and animal medicine. Damage to tissue components such as lipids is a defining feature of oxidative stress and can lead to the generation of many oxidized products, including isoprostanes (IsoP). First recognized in the early 1990s, IsoP are formed in numerous biological fluids and tissues, chemically stable, and easily measured by noninvasive means. Additionally, IsoP are highly specific indicators of lipid peroxidation and thereby are regarded as excellent biomarkers of oxidative stress. Although there have been many advancements in the detection and use of IsoP as a biomarker, there is still a paucity of knowledge regarding the biological activity of these molecules and their potential roles in pathology of oxidative stress. Furthermore, the use of IsoP has been limited in veterinary species thus far and represents an avenue of opportunity for clinical applications in veterinary practice. Examples of clinical applications of IsoP in veterinary medicine include use as a novel biomarker to guide treatment recommendations or as a target to mitigate inflammatory processes. This review will discuss the history, biosynthesis, measurement, use as a biomarker, and biological action of IsoP, particularly in the context of veterinary medicine.

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